3.1.8.1: aryldialkylphosphatase
This is an abbreviated version!
For detailed information about aryldialkylphosphatase, go to the full flat file.
Word Map on EC 3.1.8.1
-
3.1.8.1
-
arylesterase
-
paraoxonase-1
-
cholesterol
-
nerve
-
atherosclerosis
-
cardiovascular
-
low-density
-
insecticide
-
triglyceride
-
coronary
-
apolipoproteins
-
acetylcholinesterase
-
malondialdehyde
-
diminuta
-
poison
-
soman
-
p-nitrophenol
-
warfare
-
sarin
-
bioremediation
-
chlorpyrifos
-
vx
-
antiatherogenic
-
decontamination
-
bioscavenger
-
atherogenesis
-
cholinesterase
-
phenylacetate
-
medicine
-
binuclear
-
phosphotriesters
-
atherogenic
-
flavobacterium
-
carboxylesterase
-
hdl-cholesterol
-
apoa-i
-
butyrylcholinesterase
-
fluorophosphate
-
surface-expressed
-
diazoxon
-
tabun
-
thiolactone
-
g-type
-
salt-stimulated
-
triesters
-
malathion
-
ochrobactrum
-
sphingobium
-
radiobacter
-
cyclosarin
-
loligo
-
synthesis
-
environmental protection
-
drug development
-
degradation
-
biotechnology
-
diagnostics
-
agriculture
-
analysis
-
nutrition
- 3.1.8.1
- arylesterase
- paraoxonase-1
- cholesterol
- nerve
- atherosclerosis
- cardiovascular
-
low-density
-
insecticide
- triglyceride
- coronary
-
apolipoproteins
- acetylcholinesterase
- malondialdehyde
- diminuta
-
poison
- soman
- p-nitrophenol
-
warfare
- sarin
-
bioremediation
- chlorpyrifos
- vx
-
antiatherogenic
-
decontamination
-
bioscavenger
- atherogenesis
- cholinesterase
- phenylacetate
- medicine
-
binuclear
-
phosphotriesters
-
atherogenic
- flavobacterium
- carboxylesterase
-
hdl-cholesterol
- apoa-i
- butyrylcholinesterase
- fluorophosphate
-
surface-expressed
- diazoxon
- tabun
-
thiolactone
-
g-type
-
salt-stimulated
-
triesters
- malathion
- ochrobactrum
- sphingobium
- radiobacter
- cyclosarin
-
loligo
- synthesis
- environmental protection
- drug development
- degradation
- biotechnology
- diagnostics
- agriculture
- analysis
- nutrition
Reaction
Synonyms
A-esterase, A7Q26_23485, aminopeptidase P, AMPP, aryldialkylphosphatase, arylesterase, aryltriphosphatase, bacterial phosphotriesterase, DFPase, diisopropyl fluorophosphatase, esterase B1, esterase E4, esterase, organophosphate, esterase, paraoxon, esterase, pirimiphos-methyloxon, G3C9 rePON1, h-PON1, HAD, haloalkylphosphorus hydrolase, HDL-associated esterase/lactonase paraoxonase 1, HDL-PON1, high activity paraoxonase, high-density lipoprotein-associated esterase/lactonase, human paraoxonase 1, HuPON1, inner membrane protein YiaH, lactonase SsoPox, lactonase/phosphotriesterase, low activity paraoxonase, methyl parathion hydrolase, More, Mph, mPHP, OP hydrolase, OP-hydrolase, OP-hydrolyzing enzyme, OPA anhydrase, opd, OpdA, OpdD, OPH, OPHC2, organophosphate hydrolase, organophosphorous hydrolase, organophosphorus acid anhydrase, organophosphorus hydrolase, organophosphorus pesticide hydrolase, organophosphorus-hydrolyzing enzyme, paraoxon hydrolase, paraoxonase, paraoxonase 1, paraoxonase 1A, paraoxonase 3, paraoxonase-1, paraoxonase-2, paraoxonase1, parathion hydrolase, phosphotriesterase, phosphotriesterase homology protein, phosphotriesterase-like lactonase, PHP, pirimiphos-methyloxon esterase, PLL, PO.ase, PON, PON 1, PON-1, PON-aryl, PON-para, PON1, PON1A, PON2, PON3, POX, PTE, PTE S5, Rv0230c, SACI2140, Saci_2140, SacPox, Sb-PTE, serum paraoxonase, serum paraoxonase 1, SisLac, SisPox, Sso, SSO2522, SsoPox, type A paraoxonase, type B paraoxonase, VmoLac, Vmut2255, VmutPLL
ECTree
3.1.8.1 aryldialkylphosphataseAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 3.1.8.1 - aryldialkylphosphatase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate
the enzyme is activated by 87% by incubation with 1% (w/v) 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate, at 30°C
beta-Lactoglobulin
maximum activity in the presence of 0.1% (w/v) beta-lactoglobulin. There are neither additives nor synergistic effect of ZnCl2 and beta-lactoglobulin
-
commercial soap LM1
wild-type SsoPox, at 70°C, 13fold enhancement of hydrolytic activity in the presence of 0.05% LM1, and for mutant C258L/I261F/W263A at 65°C 1.3fold enhancement
-
di-oleoyl phosphatidylcholine
2.6 mM di-oleoyl phosphatidylcholine stimulates arylesterase activity of PON1 3.5fold
didecanoylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
dilauroylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
dimethyl sulfoxide
21% increase of activity at 50% (v/v) dimethyl sulfoxide, at 30°C
dimyristoylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
dipalmitoylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
ethanol
15% increase of activity at 50% (v/v) ethanol, at 30°C
HDL
modulation of substrate selectivity and catalytic stimulation by HDL
-
high-density lipoprotein
paraoxonase and arylesterase activities are stimulated by high-density lipoprotein by 2-5fold, almost independently of the apoliporotein content
-
Lubrol
the enzyme is activated by 14% by incubation with 1% Lubrol, at 30°C
-
Mg2+
-
Mg2, Mn2+ and other divalent metal ions can not substitute for Ca2+ and lead to a loss od arylesterase activity
Mn2+
-
Mg2, Mn2+ and other divalent metal ions can not substitute for Ca2+ and lead to a loss od arylesterase activity
palmitoyl-lysophosphatidylglycerol
0.01 mM, 14% stimulation of paraoxonase, 40% stimulation of diazoxonase
pyridoxal 5'-phosphate
110% activity in the presence of 5 mM pyridoxal 5'-phosphate, after 30 min at 30°C
simvastatin
-
used for treatment of hyperlipoproteinemia type IIa and IIb, simvastatin leads to lipid lowering of total and LDL cholesterol and an increase in PON1 activity in patients with both types of hyperlipoproteinemia, mechanism involving apolipoprotein A-I, overview
sodium deoxycholate
0.05%, approximately 33times catalytic efficiency enhancement compared to that without detergent
Tween 20
the enzyme is activated by 67% by incubation for 60 min with 1% (v/v) Tween 20 at 30°C
aspirin
induces paraoxonase 1 expression and stimulates enzymatic activity
aspirin
induces paraoxonase 1 expression in the liver and stimulates enzymatic activity in blood plasma
paraoxon
115 increase of activita in the presence of 0.5 mM paraoxon, after 30 min at 30°C
phosphate
-
maintains activity, modulates oligomeric state, modulates oligomeric state
salicylic acid
induces paraoxonase 1 expression and stimulates enzymatic activity
salicylic acid
induces paraoxonase 1 expression in the liver and stimulates enzymatic activity in blood plasma
SDS
0.01%, approximately 12.5 times catalytic efficiency enhancement compared to that without detergent
SDS
0.1% (w/v), 25°C, wild type enzyme, 11-fold increase of specific activity, activation is stable up to 40 h. The activating effect is reduced at 70°C
SDS
wild-type SsoPox, at 70°C, 17fold enhancement of hydrolytic activity in the presence of 0.025% SDS, and for mutant C258L/I261F/W263A at 65°C 2fold enhancement
SDS
the addition of 0.01% SDS results in an up to a 2.5folds increase in the paraoxonase catalytic efficiency, whereas the addition of 0.1% SDS enhances the efficiency by 25fold
additional information
-
efficient enzyme-catalyzed hydrolysis of OPC requires essential stabilization of the enzyme in the acidic pH region
-
additional information
-
heat-induced activation at 60°C with methyl paraoxon as substrate
-
additional information
pomegranate juice and pomegranate polyphenol extract (from variety Wonderful) consumption contributes to PON1 stabilization, increased association with high density lipoprotein, and enhanced catalytic activity
-
additional information
-
after anti-tumour necrosis factor therapy, PON-1 significantly increases after 2 weeks from the first infusion and also remains high after 6 months
-
additional information
-
binding of human phosphate binding protein amends the size of the oligomeric states and exerts a stabilizing effect on the activity
-
