Any feedback?
Literature summary for 3.1.8.1 extracted from
- Differential effect of lysophospholipids on activities of human plasma paraoxonase1, either soluble or lipid-bound (2006), Lipids, 41, 371-380.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| palmitoyl-lysophosphatidylglycerol | 0.01 mM, 14% stimulation of paraoxonase, 40% stimulation of diazoxonase | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-myristoyl-lysophosphatidylglycerol | selective, noncompetitive inhibition of paraoxonase activity | Homo sapiens | |
| 1-palmitoyl-lysophosphatidylglycerol | selective, noncompetitive inhibition of paraoxonase activity, charge interactions, inhibition is almost completely suppressed by 1 M NaCl | Homo sapiens | |
| 1-stearoyl-lysophosphatidylglycerol | selective, noncompetitive inhibition of paraoxonase activity | Homo sapiens | |
| lysophosphatidylinositol | inhibition of paraoxonase | Homo sapiens | |
| additional information | differential effect of lysophospholipids on activities of native PON1 as well as of high-density lipoprotein or dimyristoylphosphatidylcholine-bound PON1, kinetics, overview | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.42 | - |
paraoxon | pH 7.4, 25°C | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27169 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diazoxon + H2O | - |
Homo sapiens | ? | - |
? | |
| paraoxon + H2O | - |
Homo sapiens | 4-nitrophenol + diethyl phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| paraoxonase 1 | - |
Homo sapiens |
| PON1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3400 | - |
paraoxon | pH 8.0, 30°C | Brevundimonas diminuta | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.041 | - |
palmitoyl-lysophosphatidylglycerol | pH 7.4, 25°C | Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
