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3.1.8.1: aryldialkylphosphatase

This is an abbreviated version!
For detailed information about aryldialkylphosphatase, go to the full flat file.

Word Map on EC 3.1.8.1

Reaction

An aryl dialkyl phosphate
+
H2O
=
dialkyl phosphate
 +
an aryl alcohol

Synonyms

A-esterase, A7Q26_23485, aminopeptidase P, AMPP, aryldialkylphosphatase, arylesterase, aryltriphosphatase, bacterial phosphotriesterase, DFPase, diisopropyl fluorophosphatase, esterase B1, esterase E4, esterase, organophosphate, esterase, paraoxon, esterase, pirimiphos-methyloxon, G3C9 rePON1, h-PON1, HAD, haloalkylphosphorus hydrolase, HDL-associated esterase/lactonase paraoxonase 1, HDL-PON1, high activity paraoxonase, high-density lipoprotein-associated esterase/lactonase, human paraoxonase 1, HuPON1, inner membrane protein YiaH, lactonase SsoPox, lactonase/phosphotriesterase, low activity paraoxonase, methyl parathion hydrolase, More, Mph, mPHP, OP hydrolase, OP-hydrolase, OP-hydrolyzing enzyme, OPA anhydrase, opd, OpdA, OpdD, OPH, OPHC2, organophosphate hydrolase, organophosphorous hydrolase, organophosphorus acid anhydrase, organophosphorus hydrolase, organophosphorus pesticide hydrolase, organophosphorus-hydrolyzing enzyme, paraoxon hydrolase, paraoxonase, paraoxonase 1, paraoxonase 1A, paraoxonase 3, paraoxonase-1, paraoxonase-2, paraoxonase1, parathion hydrolase, phosphotriesterase, phosphotriesterase homology protein, phosphotriesterase-like lactonase, PHP, pirimiphos-methyloxon esterase, PLL, PO.ase, PON, PON 1, PON-1, PON-aryl, PON-para, PON1, PON1A, PON2, PON3, POX, PTE, PTE S5, Rv0230c, SACI2140, Saci_2140, SacPox, Sb-PTE, serum paraoxonase, serum paraoxonase 1, SisLac, SisPox, Sso, SSO2522, SsoPox, type A paraoxonase, type B paraoxonase, VmoLac, Vmut2255, VmutPLL

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.8 Phosphoric-triester hydrolases
                3.1.8.1 aryldialkylphosphatase

KM Value

KM Value on EC 3.1.8.1 - aryldialkylphosphatase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.088
(1E)-but-1-en-1-yl dibutyl phosphate
pH 9.0, 25°C
0.35 - 3.2
(S)-[2-[di(propan-2-yl)amino]ethyl] O,O-diethyl phosphorothioate
2.1
2,4-dinitrophenyl diethyl phosphate
pH 8.0
1.3
2,6-difluorophenyl diethyl phosphate
pH 8.0
0.91
2-fluoro 4-nitrophenyl diethyl phosphate
pH 8.0
1.8
3,5-dinitrophenyl diethyl phosphate
pH 8.0
2.1
3-cyanophenyl diethyl phosphate
pH 8.0
1.7
3-fluoro 4-nitrophenyl diethyl phosphate
-
2
3-fluorophenyl diethyl phosphate
pH 8.0
1.3
3-nitrophenyl diethyl phosphate
pH 8.0
0.15 - 4
4-acetylphenyl (R)-2-methylpropyl methylphosphonate
0.03 - 4.5
4-acetylphenyl (S)-2-methylpropyl methylphosphonate
0.31
4-acetylphenyl cyclohexyl methyl (R)-phosphate
pH 8.5, 30°C
0.12
4-acetylphenyl cyclohexyl methyl (S)-phosphate
pH 8.5, 30°C
0.55
4-carbamoylphenyl diethyl phosphate
pH and temperature not specified in the publication
1.9
4-chlorophenyl diethyl phosphate
pH 8.0
1.9
4-cyanophenyl diethyl phosphate
pH 8.0
1.56
4-diethyl phosphate acetophenone
pH 8.0
1.2
4-diethyl phosphate benzaldehyde
pH 8.0
1.9
4-diethyl phosphate methyl benzoate
pH 8.0
0.8
4-nitrophenyl diethyl phosphate
pH 8.0
0.091 - 0.2
7-diethylphospho-6,8-difluor-4-methylumbelliferyl
0.032 - 0.51
chlorpyrifos
0.642
CMP-coumarin
pH 8.3, 25°C
0.071
Coumaphos
-
pH 7.2, 25°C
0.059
cyclohexyl ethyl 4-nitrophenyl (R)-phosphate
pH 8.5, 30°C
0.054
cyclohexyl ethyl 4-nitrophenyl (S)-phosphate
pH 8.5, 30°C
1.1
cyclohexyl methyl 4-nitrophenyl (R)-phosphate
pH 8.5, 30°C
0.053
cyclohexyl methyl 4-nitrophenyl (S)-phosphate
pH 8.5, 30°C
0.006
cyclohexyl methyl phenyl (R)-phosphate
pH 8.5, 30°C
0.236 - 7.6
demeton-S
1.2 - 23.31
demeton-S methyl
1.33
diazoxon
recombinant wild type enzyme, in 0.1 M Tris-HCl (pH 8.5), 2 M NaCl, and 2 mM CaCl2
0.05 - 0.11
dibutyl 2,2,3,3-tetrafluorobutyl phosphate
0.17
dibutyl 3,3-difluorobutyl phosphate
pH 9.0, 25°C
0.43
dibutyl 4-acetophenyl phosphate
pH and temperature not specified in the publication
0.15
dibutyl 4-nitrophenyl phosphate
pH and temperature not specified in the publication
0.14
dibutyl phenyl phosphate
pH and temperature not specified in the publication
0.95
diethyl 2,4,6-trifluorophenyl phosphate
pH and temperature not specified in the publication
0.39
diethyl 2,4-difluorophenyl phosphate
pH and temperature not specified in the publication
1.1
diethyl 2,6-difluoro-4-nitrophenyl phosphate
pH and temperature not specified in the publication
0.63
diethyl 2-fluoro-4-nitrophenyl phosphate
pH and temperature not specified in the publication
1.3
diethyl 2-fluorophenyl phosphate
pH and temperature not specified in the publication
0.25
diethyl 3-fluoro-4-nitrophenyl phosphate
pH and temperature not specified in the publication
0.27
diethyl 3-fluorophenyl phosphate
pH and temperature not specified in the publication
0.24
diethyl 4-acetophenyl phosphate
pH and temperature not specified in the publication
0.41 - 7
diethyl 4-chlorophenyl phosphate
0.3 - 0.6
diethyl 4-chlorophenyl thiophosphate
0.67
diethyl 4-cyanophenyl phosphate
pH and temperature not specified in the publication
1.6
diethyl 4-fluorophenyl phosphate
pH and temperature not specified in the publication
1.2
diethyl 4-formylphenyl phosphate
pH and temperature not specified in the publication
0.44
diethyl 4-methoxyphenyl phosphate
pH and temperature not specified in the publication
0.083 - 1.9
diethyl 4-nitrophenyl phosphate
0.67 - 0.889
diethyl paraoxon
0.46
diethyl pentafluoro-phenyl phosphate
pH and temperature not specified in the publication
1.1
diethyl phenyl phosphate
pH and temperature not specified in the publication
0.0017 - 1.586
diethyl-paraoxon
0.0086
diethylumbelliferyl phosphate
-
pH 7.5, 25°C, recombinant mutant enzyme G137D
0.76
dimethyl 4-nitrophenyl phosphate
pH 8.5, 30°C
0.5 - 1.3
dimethyl-paraoxon
2.1
ethyl paraoxon
-
at 35°C, pH 9.0
0.1
ethyl parathion
-
-
0.345
ethyl phenyl parathion
-
-
0.581
ethyl-paraoxon
pH 8.0, 70°C
0.16 - 1.16
malathion
0.061
methyl 4-nitrophenyl phenyl (R)-phosphate
pH 8.5, 30°C
0.25
methyl 4-nitrophenyl phenyl (S)-phosphate
pH 8.5, 30°C
2.3
methyl 4-nitrophenyl propan-2-yl (R)-phosphate
pH 8.5, 30°C
0.036
methyl 4-nitrophenyl propan-2-yl (S)-phosphate
pH 8.5, 30°C
1
methyl 4-[(diethoxyphosphoryl)oxy]benzoate
pH and temperature not specified in the publication
0.08
methyl bis(4-nitrophenyl) phosphate
pH 8.5, 30°C
0.05 - 2.79
methyl paraoxon
0.052 - 0.41
methyl parathion
0.073 - 1.22
methylparathion
4.6
O,O'-(diisobutyl)methylphosphonate
pH 10.5, 25°C, recombinant His6-tagged enzyme
0.085
O,O,S-tributyl phosphorothioate
pH 9.0, 25°C
1400
O-(isobutyl)methylphosphonate
pH 10.5, 25°C, recombinant His6-tagged enzyme
0.2
O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate
0.5
O-isobutyl-S-[2-(diethylamino)ethyl]methylphosphonothioic acid
-
in 50 mM Tris-HCl buffer, 10 mM CaCl2, pH 7.4
0.005 - 24.25
paraoxon
0.015 - 1.7
parathion
4
pentafluorophenyl diethyl phosphate
pH 8.0
1.4 - 3.5
phenyl acetate
0.187
phosmet
-
pH 7.2, 25°C
0.15 - 5.87
S-(2-[di(propan-2-yl)amino]ethyl)O-ethyl methylphosphonothioate
0.074 - 0.21
sarin
0.27 - 0.44
soman
1.1 - 8.9
Tabun
-
-
additional information
additional information
-