2.1.1.45: thymidylate synthase

This is an abbreviated version!
For detailed information about thymidylate synthase, go to the full flat file.

Word Map on EC 2.1.1.45

2.1.1.45

5-fluorouracil

thymidine

colorectal

dihydrofolate

antifolate

methotrexate

dihydropyrimidine

pyrimidine

fluoropyrimidine

phosphorylase

ribonucleotide

leucovorin

pemetrexed

resect

fdump

uracil

mthfr

casey

schedule

polyglutamates

non-small

cisplatin

folylpolyglutamate

deoxyuridine

oxaliplatin

5-fluoro-2'-deoxyuridine

antimetabolite

orotate

irinotecan

capecitabine

5-fu-based

ccrf-cem

folate-dependent

gemcitabine

folinic

formyltransferase

quinazoline

glycinamide

dttp

polyglutamylation

2'-deoxyuridine

tegafur

medicine

methotrexate-resistant

deoxycytidylate

cross-complementing

drug development

transformylase

5-fu-induced

dutpase

aminopterin

deoxythymidine

Reaction

5,10-methylenetetrahydrofolate

+

dUMP

=

dihydrofolate

+

dTMP

Synonyms

BgDHFR-TS, bifunctional TS-DHFR, DFR-TS, DHFR-TS, DHFR�TS, dihydrofolate reductase-thymidylate synthase, dTMP synthase, HTS, human TS, LBRM_06_0830, methylenetetrahydrofolate:dUMP C-methyltransferase, More, Thy1, ThyA, thymidylate synthase, thymidylate synthase A, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase, ThyX, TMP synthetase, TMPS, TS, TS-DHFR, TSase, TYMS, Y110A7A.4

ECTree

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.45 thymidylate synthase

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Results	in table
24	Activating Compound
35645	AA Sequence
100	Application
1	CAS Registry Number
67	Cloned(Commentary)
155	Cofactor
62	Crystallization (Commentary)
7739	Disease/ Diagnostics
7	Expression
25	General Information
16	General Stability
186	IC50 Value
1137	Inhibitors
13	kcat/KM [mM/s]
140	Ki Value [mM]
185	KM Value [mM]
5	Localization
14	Metals/Ions
103	Molecular Weight [Da]
322	Natural Substrates/ Products (Substrates)
2481	Organism
14	Pathway
665	PDB ID
36	pH Optimum
8	pH Range
4	pH Stability
3	Posttranslational Modification
58	Protein Variants
104	Purification (Commentary)
2	Reaction
13	Reaction Type
509	Reference
150	Source Tissue
50	Specific Activity [micromol/min/mg]
31	Storage Stability
891	Substrates and Products (Substrate)
137	Subunits
78	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
4	Temperature Range [°C]
10	Temperature Stability [°C]
23	Turnover Number [1/s]

Organism

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Organism on EC 2.1.1.45 - thymidylate synthase

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Abies sp.

pine

-

-

Manually annotated by BRENDA team

Acinetobacter baumannii

-

-

-

Manually annotated by BRENDA team

-

-

-

Manually annotated by BRENDA team

Aeromonas hydrophila

-

-

-

Manually annotated by BRENDA team

Angiostrongylus cantonensis

metastrongyloid nematode, synonym Parastrongylus

-

-

Manually annotated by BRENDA team

Archaeoglobus fulgidus

-

-

-

Manually annotated by BRENDA team

-

-

-

Manually annotated by BRENDA team

Aspergillus clavatus

-

-

-

Manually annotated by BRENDA team

Aspergillus fischeri

-

-

-

Manually annotated by BRENDA team

Aspergillus fumigatus

-

-

-

Manually annotated by BRENDA team

Aspergillus nidulans

-

-

-

Manually annotated by BRENDA team

Babesia gibsoni

show

Bacillus amyloliquefaciens

-

-

-

Manually annotated by BRENDA team

Bacillus anthracis

-

-

-

Manually annotated by BRENDA team

Bacillus cereus

-

-

-

Manually annotated by BRENDA team

Bacillus licheniformis

-

-

-

Manually annotated by BRENDA team

Bacillus mycoides

-

-

-

Manually annotated by BRENDA team

Bacillus phage phi3T

-

-

-

Manually annotated by BRENDA team

Bacillus subtilis

show

Bacteroides fragilis

-

-

-

Manually annotated by BRENDA team

Bacteroides thetaiotaomicron

-

-

-

Manually annotated by BRENDA team

Bartonella bacilliformis

-

-

-

Manually annotated by BRENDA team

Bartonella henselae

-

-

-

Manually annotated by BRENDA team

Bartonella quintana

-

-

-

Manually annotated by BRENDA team

Bordetella bronchiseptica

-

-

-

Manually annotated by BRENDA team

Bordetella parapertussis

-

-

-

Manually annotated by BRENDA team

Bordetella pertussis

-

-

-

Manually annotated by BRENDA team

calf

392255, 485359, 485363, 485369, 485373, 485381, 485383, 485402, 485404

-

-

Manually annotated by BRENDA team

Brucella abortus

-

-

-

Manually annotated by BRENDA team

Brucella melitensis

-

-

-

Manually annotated by BRENDA team

-

-

-

Manually annotated by BRENDA team

-

-

-

Manually annotated by BRENDA team

Burkholderia ambifaria

-

-

-

Manually annotated by BRENDA team

Burkholderia dolosa

-

-

-

Manually annotated by BRENDA team

Burkholderia mallei

-

-

-

Manually annotated by BRENDA team

Burkholderia multivorans

-

-

-

Manually annotated by BRENDA team

Burkholderia pseudomallei

-

-

-

Manually annotated by BRENDA team

Burkholderia vietnamiensis

-

-

-

Manually annotated by BRENDA team

Caenorhabditis elegans

-

-

-

Manually annotated by BRENDA team

Caenorhabditis elegans Bristol N2

-

-

-

Manually annotated by BRENDA team

Candida albicans

-

485403, 485404, 485415, 703220

-

-

Manually annotated by BRENDA team

Chaetomium globosum

-

-

-

Manually annotated by BRENDA team

Chlamydomonas reinhardtii

-

-

-

Manually annotated by BRENDA team

Chromobacterium violaceum

-

-

-

Manually annotated by BRENDA team

Clostridioides difficile

-

-

-

Manually annotated by BRENDA team

Coccidioides immitis

-

-

-

Manually annotated by BRENDA team

Comamonas testosteroni

-

-

-

Manually annotated by BRENDA team

Corynebacterium diphtheriae

-

-

-

Manually annotated by BRENDA team

Corynebacterium glutamicum

-

-

-

Manually annotated by BRENDA team

Corynebacterium glutamicum ATCC 13032

-

-

-

Manually annotated by BRENDA team

Corynebacterium glutamicum NCHU 87078

-

-

-

Manually annotated by BRENDA team

Corynebacterium jeikeium

-

-

-

Manually annotated by BRENDA team

Coxiella burnetii

-

-

-

Manually annotated by BRENDA team

Crithidia fasciculata

show

Cryptococcus neoformans

show

Cryptococcus neoformans B-3501A

show

Cryptosporidium hominis

show

Cryptosporidium parvum

-

-

-

Manually annotated by BRENDA team

Cutibacterium acnes

-

-

-

Manually annotated by BRENDA team

-

-

-

Manually annotated by BRENDA team

carrot, wild and culture form

-

-

Manually annotated by BRENDA team

Debaryomyces hansenii

-

-

-

Manually annotated by BRENDA team

Drosophila melanogaster

-

-

-

Manually annotated by BRENDA team

Encephalitozoon cuniculi

-

-

-

Manually annotated by BRENDA team

Enterobacter sp.

-

-

-

Manually annotated by BRENDA team

Enterobacteria phage T6

-

-

-

Manually annotated by BRENDA team

Enterococcus faecalis

show

Enterococcus faecalis ATCC 700802

-

UniProt

Manually annotated by BRENDA team

Enterococcus faecium

show

Escherichia coli

show

Escherichia coli B / ATCC 11303

-

485357, 485365, 485371, 485372, 485373, 485375, 485376, 485380, 485383, 485388

-

-

Manually annotated by BRENDA team

Escherichia coli EM 20031 K12

-

-

-

Manually annotated by BRENDA team

Escherichia coli R2

-

-

-

Manually annotated by BRENDA team

Escherichia phage T2

-

485363, 485369, 485380, 485381, 485388

-

-

Manually annotated by BRENDA team

Francisella tularensis

-

-

-

Manually annotated by BRENDA team

Fusobacterium nucleatum

-

-

-

Manually annotated by BRENDA team

show

Geobacillus virus E2

show

Haemophilus influenzae

-

-

-

Manually annotated by BRENDA team

Helicobacter pylori

show

Helicobacter pylori SS1

-

-

-

Manually annotated by BRENDA team

show

Human alphaherpesvirus 1

-

-

-

Manually annotated by BRENDA team

Kitasatospora aureofaciens

industrial strain BMK

-

-

Manually annotated by BRENDA team

Lacticaseibacillus casei

show

Lacticaseibacillus casei TS N229D

and strain TS N229C

-

-

Manually annotated by BRENDA team

Lactococcus lactis

-

-

-

Manually annotated by BRENDA team

Legionella pneumophila

-

-

-

Manually annotated by BRENDA team

Leishmania amazonensis

-

-

-

Manually annotated by BRENDA team

Leishmania braziliensis

show

Leishmania donovani

-

-

-

Manually annotated by BRENDA team

Leishmania infantum

-

-

-

Manually annotated by BRENDA team

Leishmania major

show

Leishmania panamensis

-

UniProt

Manually annotated by BRENDA team

Leishmania tropica

-

-

-

Manually annotated by BRENDA team

Listeria monocytogenes

-

-

-

Manually annotated by BRENDA team

Malacoplasma penetrans

-

-

-

Manually annotated by BRENDA team

Methanocaldococcus jannaschii

-

-

-

Manually annotated by BRENDA team

Methanopyrus kandleri

AV19

-

-

Manually annotated by BRENDA team

Methanothermobacter thermautotrophicus

-

-

-

Manually annotated by BRENDA team

show

Mycobacterium avium

-

-

-

Manually annotated by BRENDA team

Mycobacterium leprae

-

-

-

Manually annotated by BRENDA team

Mycobacterium tuberculosis

show

Mycobacterium tuberculosis H37Rv

isoform ThyA

UniProt

Manually annotated by BRENDA team

Mycobacterium tuberculosis variant bovis

-

-

-

Manually annotated by BRENDA team

Mycobacterium ulcerans

-

-

-

Manually annotated by BRENDA team

Mycoplasma genitalium

-

-

-

Manually annotated by BRENDA team

Mycoplasma pneumoniae

-

-

-

Manually annotated by BRENDA team

Neisseria gonorrhoeae

-

-

-

Manually annotated by BRENDA team

Neisseria gonorrhoeae MS11

-

-

-

Manually annotated by BRENDA team

Neisseria meningitidis

-

-

-

Manually annotated by BRENDA team

Nicotiana tabacum

tobacco

-

-

Manually annotated by BRENDA team

no activity in Aeropyrum pernix

-

-

-

Manually annotated by BRENDA team

no activity in Aquifex aeolicus

-

-

-

Manually annotated by BRENDA team

no activity in Pyrobaculum aerophilum

-

-

-

Manually annotated by BRENDA team

no activity in Pyrococcus abyssi

-

-

-

Manually annotated by BRENDA team

no activity in Pyrococcus furiosus

DSM 3638

-

-

Manually annotated by BRENDA team

no activity in Pyrococcus horikoshii

-

-

-

Manually annotated by BRENDA team

no activity in Sulfolobus solfataricus

-

-

-

Manually annotated by BRENDA team

no activity in Sulfolobus tokodaii

-

-

-

Manually annotated by BRENDA team

no activity in Thermoplasma acidophilum

-

-

-

Manually annotated by BRENDA team

no activity in Thermoplasma volcanium

-

-

-

Manually annotated by BRENDA team

no activity in Thermotoga maritima

-

-

-

Manually annotated by BRENDA team

Nocardia farcinica

-

-

-

Manually annotated by BRENDA team

Novosphingobium aromaticivorans

-

-

-

Manually annotated by BRENDA team

Pasteurella multocida

-

-

-

Manually annotated by BRENDA team

Penaeus vannamei

-

UniProt

Manually annotated by BRENDA team

Plasmodium berghei

-

-

-

Manually annotated by BRENDA team

Plasmodium falciparum

show

Plasmodium falciparum TM4/8.2

-

Uniprot

Manually annotated by BRENDA team

Plasmodium malariae

-

-

-

Manually annotated by BRENDA team

Plasmodium vivax

-

-

-

Manually annotated by BRENDA team

Plasmodium yoelii

-

-

-

Manually annotated by BRENDA team

Pneumocystis carinii

show

Porphyromonas gingivalis

-

-

-

Manually annotated by BRENDA team

Pseudomonas aeruginosa

-

-

-

Manually annotated by BRENDA team

Pseudomonas mendocina

-

-

-

Manually annotated by BRENDA team

Rattus norvegicus

show

Rattus norvegicus Wistar

-

-

-

Manually annotated by BRENDA team

Saccharomyces cerevisiae

show

Salmonella enterica

-

-

-

Manually annotated by BRENDA team

Salmonella enterica subsp. enterica serovar Paratyphi A

-

-

-

Manually annotated by BRENDA team

Salmonella enterica subsp. enterica serovar Typhi

-

-

-

Manually annotated by BRENDA team

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

-

Manually annotated by BRENDA team

Schistosoma japonicum

-

-

-

Manually annotated by BRENDA team

Serratia proteamaculans

-

-

-

Manually annotated by BRENDA team

Shewanella putrefaciens

-

-

-

Manually annotated by BRENDA team

Shigella boydii

-

-

-

Manually annotated by BRENDA team

Shigella dysenteriae

-

-

-

Manually annotated by BRENDA team

Shigella flexneri

-

-

-

Manually annotated by BRENDA team

Shigella sonnei

-

-

-

Manually annotated by BRENDA team

Shrimp white spot syndrome virus

-

UniProt

Manually annotated by BRENDA team

Staphylococcus aureus

show

Staphylococcus epidermidis

-

-

-

Manually annotated by BRENDA team

Staphylococcus haemolyticus

-

-

-

Manually annotated by BRENDA team

Staphylococcus saprophyticus

-

-

-

Manually annotated by BRENDA team

Stenotrophomonas maltophilia

-

-

-

Manually annotated by BRENDA team

Streptococcus agalactiae

-

-

-

Manually annotated by BRENDA team

Streptococcus mutans

-

-

-

Manually annotated by BRENDA team

Streptococcus pneumoniae

-

485372, 485375, 485380, 485389, 703220

-

-

Manually annotated by BRENDA team

Streptococcus pyogenes

-

-

-

Manually annotated by BRENDA team

Streptococcus sanguinis

-

-

-

Manually annotated by BRENDA team

Strigomonas oncopelti

-

-

-

Manually annotated by BRENDA team

pig

485362, 485395, 485404

-

-

Manually annotated by BRENDA team

Tequatrovirus T4

-

485366, 485369, 485388, 485403, 485408, 485409, 485411, 485415, 694135

-

-

Manually annotated by BRENDA team

Tequintavirus T5

-

-

-

Manually annotated by BRENDA team

Tetradesmus obliquus

unicellular green algae

-

-

Manually annotated by BRENDA team

Thermotoga maritima

-

-

-

Manually annotated by BRENDA team

Toxoplasma gondii

show

Trichinella pseudospiralis

-

-

-

Manually annotated by BRENDA team

Trichinella spiralis

-

485427, 485430, 703220

-

-

Manually annotated by BRENDA team

Trypanosoma brucei

show

Trypanosoma brucei 427

-

UniProt

Manually annotated by BRENDA team

Trypanosoma brucei gambiense

-

-

-

Manually annotated by BRENDA team

Trypanosoma congolense

causes nagana, the equivalent disease of cattle

-

-

Manually annotated by BRENDA team

Trypanosoma cruzi

show

Trypanosoma lewisi

natural pathogen of rats

-

-

Manually annotated by BRENDA team

Trypanosoma rhodesiense

causes human sleeping sickness

-

-

Manually annotated by BRENDA team

Vibrio alginolyticus

-

-

-

Manually annotated by BRENDA team

Vibrio cholerae serotype O1

-

-

-

Manually annotated by BRENDA team

Vibrio parahaemolyticus

-

-

-

Manually annotated by BRENDA team

Vibrio vulnificus

-

-

-

Manually annotated by BRENDA team

Yersinia bercovieri

-

-

-

Manually annotated by BRENDA team

Yersinia enterocolitica

-

-

-

Manually annotated by BRENDA team

Yersinia frederiksenii

-

-

-

Manually annotated by BRENDA team

Yersinia intermedia

-

-

-

Manually annotated by BRENDA team

Yersinia mollaretii

-

-

-

Manually annotated by BRENDA team

Yersinia pestis

-

-

-

Manually annotated by BRENDA team

Yersinia pseudotuberculosis

-

-

-

Manually annotated by BRENDA team

[Candida] glabrata

-

-

-

Manually annotated by BRENDA team

[Haemophilus] ducreyi

-

-

-

Manually annotated by BRENDA team

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Release 2023.1 (January 2023)