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Literature summary for 2.1.1.45 extracted from

  • Nief, N.; Le Morvan, V.; Robert, J.
    Involvement of gene polymorphisms of thymidylate synthase in gene expression, protein activity and anticancer drug cytotoxicity using the NCI-60 panel (2007), Eur. J. Cancer, 43, 955-962.
    View publication on PubMed
Search for more literature for 2.1.1.45

Application

Application Comment Organism
medicine TYMS is the target enzyme of fluorouracil, an antimetabolite widely used in the treatment of colorectal, head-and-neck, breast cancers, pancreatic cancer and hepatocellular carcinoma Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-fluorouracil
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP Homo sapiens it is a key enzyme for the synthesis of the DNA-specific nucleotide thymidylate 7,8-dihydrofolate + dTMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information NCI60 panel of 60 human tumor cell lines, the NCI-60 model is able to provide interesting information about the role of TYMS gene polymorphisms on TYMS mRNA expression and catalytic activity Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
 Homo sapiens 7,8-dihydrofolate + dTMP
-
 ?
5,10-methylenetetrahydrofolate + dUMP it is a key enzyme for the synthesis of the DNA-specific nucleotide thymidylate Homo sapiens 7,8-dihydrofolate + dTMP
-
 ?

Synonyms

Synonyms Comment Organism
TYMS
-
 Homo sapiens