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2.1.1.45: thymidylate synthase

This is an abbreviated version!
For detailed information about thymidylate synthase, go to the full flat file.

Word Map on EC 2.1.1.45

Reaction

5,10-methylenetetrahydrofolate
+
dUMP
=
dihydrofolate
 +
dTMP

Synonyms

BgDHFR-TS, bifunctional TS-DHFR, DFR-TS, DHFR-TS, DHFR–TS, dihydrofolate reductase-thymidylate synthase, dTMP synthase, HTS, human TS, LBRM_06_0830, methylenetetrahydrofolate:dUMP C-methyltransferase, More, Thy1, ThyA, thymidylate synthase, thymidylate synthase A, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase, ThyX, TMP synthetase, TMPS, TS, TS-DHFR, TSase, TYMS, Y110A7A.4

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.45 thymidylate synthase

Specific Activity

Specific Activity on EC 2.1.1.45 - thymidylate synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00035
0.00119
-
blood form
0.00156
-
culture form
0.002135
-
Gardner lymphosarcoma
0.003519
-
sarcoma 180
0.0063
-
-
0.0088
purified recombinant bifunctional enzyme DHFR-TS with Tsf tag, pH 7.4, 25°C from a TS-deficient Escherichia coli strain (thyA-)
0.01
-
-
0.1024
-
-
1.26
pH 7.2, 22°C
1.3
-
affinity chromatography
1.33
-
-
14.2
Tequintavirus T5
-
-
14.45
Tequatrovirus T4
-
-
414
-
purified enzyme, in 50 mM Tris-HCl buffer (pH 8.0), at 37°C