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Literature summary for 2.1.1.45 extracted from
- Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase (2010), Bioorg. Med. Chem., 18, 3361-3370.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation of serine 124 in human thymidylate synthase lowers the catalytic activity of the enzyme. The phosphorylation changes the collective motions of the enzyme, consisting of the suppression of motions especially in the regions flanking the entrance to the active site | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | dihydrofolate + dTMP | - |
? |  |
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Release 2023.1 (January 2023)
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