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Literature summary for 2.1.1.45 extracted from

  • Gupta, V.S.; Meldrum, J.B.
    Purification and properties of thymidylate synthetase from pig thymus (1972), Can. J. Biochem., 50, 353-362.
No PubMed abstract available
Search for more literature for 2.1.1.45

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol maximal catalytic activity only in presence of sulfhydryl compounds Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP Sus scrofa
-
 dihydrofolate + dTMP
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
 pig
-

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
 Sus scrofa dihydrofolate + dTMP
-
 ?
5,10-methylenetetrahydrofolate + dUMP
-
 Sus scrofa dihydrofolate + dTMP
-
 r
5,10-methylenetetrahydrofolate + uridine 5'-phosphate
-
 Sus scrofa dihydrofolate + TMP
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.6 6.8
-
 Sus scrofa
7.2 7.4 double pH-optimum in 2-N-morpholinoethane sulfonic acid buffer Sus scrofa