2.1.1.45: thymidylate synthase
This is an abbreviated version!
For detailed information about thymidylate synthase, go to the full flat file.
Word Map on EC 2.1.1.45
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2.1.1.45
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5-fluorouracil
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thymidine
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colorectal
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dihydrofolate
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antifolate
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methotrexate
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dihydropyrimidine
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pyrimidine
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fluoropyrimidine
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phosphorylase
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ribonucleotide
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leucovorin
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pemetrexed
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resect
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fdump
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uracil
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mthfr
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casey
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schedule
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polyglutamates
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non-small
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cisplatin
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folylpolyglutamate
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deoxyuridine
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oxaliplatin
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5-fluoro-2'-deoxyuridine
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antimetabolite
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orotate
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irinotecan
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capecitabine
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5-fu-based
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ccrf-cem
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folate-dependent
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gemcitabine
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folinic
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formyltransferase
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quinazoline
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glycinamide
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dttp
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polyglutamylation
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2'-deoxyuridine
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tegafur
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medicine
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methotrexate-resistant
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deoxycytidylate
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cross-complementing
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drug development
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transformylase
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5-fu-induced
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dutpase
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aminopterin
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deoxythymidine
- 2.1.1.45
- 5-fluorouracil
- thymidine
- colorectal
- dihydrofolate
- antifolate
- methotrexate
- dihydropyrimidine
- pyrimidine
-
fluoropyrimidine
- phosphorylase
- ribonucleotide
- leucovorin
- pemetrexed
-
resect
- fdump
- uracil
- mthfr
-
casey
-
schedule
- polyglutamates
-
non-small
- cisplatin
- folylpolyglutamate
- deoxyuridine
- oxaliplatin
- 5-fluoro-2'-deoxyuridine
-
antimetabolite
- orotate
- irinotecan
- capecitabine
-
5-fu-based
-
ccrf-cem
-
folate-dependent
- gemcitabine
-
folinic
-
formyltransferase
- quinazoline
- glycinamide
- dttp
-
polyglutamylation
- 2'-deoxyuridine
-
tegafur
- medicine
-
methotrexate-resistant
- deoxycytidylate
-
cross-complementing
- drug development
-
transformylase
-
5-fu-induced
- dutpase
- aminopterin
- deoxythymidine
Reaction
Synonyms
BgDHFR-TS, bifunctional TS-DHFR, DFR-TS, DHFR-TS, DHFR–TS, dihydrofolate reductase-thymidylate synthase, dTMP synthase, HTS, human TS, LBRM_06_0830, methylenetetrahydrofolate:dUMP C-methyltransferase, More, Thy1, ThyA, thymidylate synthase, thymidylate synthase A, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase, ThyX, TMP synthetase, TMPS, TS, TS-DHFR, TSase, TYMS, Y110A7A.4
ECTree
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Storage Stability
Storage Stability on EC 2.1.1.45 - thymidylate synthase
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-20°C, 40% glycerol, stable over 2 months, 50% loss of activity by 24 h storage without glycerol
-20°C, can be stored in 10% glycerol, 0.05 M Tris-HCl, pH7.4 and 10 mM 2-mercaptoethanol for 30 days with a loss of approximately 50% activity
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-20°C, enzyme can be stored frozen for several months without significant loss of activity
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-20°C, in presence of 0.1% Triton X-100 and 10% glycerol, no loss of activity when stored in lysis buffer for several weeks
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-20°C, purified recombinant protein, stable at pH 6.0 over a period of 1 month
-20°C, sulfate-precipitated enzyme in 0.1 M potassium phosphate, 0.01 M dithiothreitol, pH 7.1can be kept at least 4 months with only 25% loss of activity
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-20°C, TS activity of crude enzyme remains unchanged for 1 month of storage, purified enzyme loses 50% of its activity within 3-4 weeks
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-25°C enzyme retains activity for 3 months when stored in presence of thiols, without thiols enzyme loses all activity in 2 days
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-70°C preparation with 0.1% bovine serum albumin is stable up to 8 weeks of storage
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0-5°C, enzyme is stable over a period of months in presence of 10 mM 2-mercaptoethanol in capped vessels layered with argon
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0°C, enzyme can be maintained in its active form in presence of saccharose or glycerol for several days
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0°C, enzyme can be stored in a concentrated solution for 2 weeks without a loss in activity
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4°C enzyme can be maintained for at least 4 months with little or no loss in activity
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4°C enzyme retains activity for 3 months when stored in presence of thiols, without thiols enzyme loses all activity in 2 days
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4°C, enzyme retains activity for about 3 weeks when stored with 20 mM dithiothreitol and 0.1 mM dUMP, without dithiothreitol purified enzyme is inactivated totally in 2 days, without dUMP enzyme keeps 50% activity after 1 week
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4°C, in presence of 0.1% Triton X-100 and 10% glycerol, no loss of activity when stored in lysis buffer for at least 2 weeks
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-20°C, purified recombinant protein, stable at pH 6.0 over a period of 1 month
-20°C, purified recombinant protein, stable at pH 6.0 over a period of 1 month