Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.45 extracted from

  • Kim, S.; Park, D.H.; Shim, J.
    Thymidylate synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis elegans (2008), Mol. Cells, 26, 344-349.
    View publication on PubMed
Search for more literature for 2.1.1.45

Inhibitors

Inhibitors Comment Organism Structure
5-fluorouracil
-
 Caenorhabditis elegans

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Caenorhabditis elegans Bristol N2
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
 Caenorhabditis elegans dihydrofolate + dTMP
-
 ?
5,10-methylenetetrahydrofolate + dUMP
-
 Caenorhabditis elegans Bristol N2 dihydrofolate + dTMP
-
 ?

Synonyms

Synonyms Comment Organism
Y110A7A.4
-
 Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
N5,N10-methylenetetrahydrofolate
-
 Caenorhabditis elegans

General Information

General Information Comment Organism
physiological function thymidylate synthase plays an essential role in embryogenesis, embryos with their thymidylate synthase function inhibited show a retarded embryo development and irregular cell sizes Caenorhabditis elegans