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Information on EC 3.4.22.27 - cathepsin S
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EC Tree
3.4.22.27 cathepsin SSpecify your search results
Word Map
- 3.4.22.27
- cathepsins
- lysosomal
-
point-of-care
- cystatins
- dendritic
- atherosclerosis
- proteinases
- elastin
- papain
-
antigen-presenting
-
histocompatibility
- autoimmune
- drug development
-
lacrimal
-
papain-like
- diagnostics
-
ii-associated
-
elastolytic
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resource-limited
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s-deficient
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procathepsins
-
l-like
- pharmacology
- endostatin
- microglial
- fractalkine
- medicine
- par2
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collagenolytic
- syphilis
-
ii-restricted
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and more activity on the Z-Val-Val-Arg-/- compound
Synonyms
cathepsin s, pocts, cat s, cat-s, pfctssa, socats, cath s, rs1136774, rs7534124, rs16827671, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C01.034
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-
-
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Cat S
Cat-S
cathepsin S
CatS
CTSS
Cat S
-
-
cathepsin S
-
-
cathepsin S
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cathepsin S
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and more activity on the Z-Val-Val-Arg-/- compound
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and more activity on the Z-Val-Val-Arg-/- compound
-
-
-
-
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and more activity on the Z-Val-Val-Arg-/- compound
the catalytic triad is formed by Cys25, His164, and Asn184, the substrate binding site lies between the N-terminal and the C-terminal domain, cysteine protease mechanism, overview
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
hydrolysis of peptide bond
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-
-
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CAS REGISTRY NUMBER
COMMENTARY
71965-46-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(4-methyl-7-[[(2S)-2-(4-[(1S)-1-(4-methylcyclohexyl)-1-[(thiophen-3-ylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-2-oxo-2H-chromen-3-yl)acetic acid + H2O
?
-
-
-
-
?
(7-methoxycoumarin-4-yl)-acetyl-GRWHPMGAPWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
(7-methoxycoumarin-4-yl)-acetyl-GRWHPMG + APWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
specific substrate for CatS
-
-
?
(7-methoxycoumarin-4-yl)-acetyl-GRWPPMGLPWEK(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
(7-methoxycoumarin-4-yl)-acetyl-GRWPPMG + LPWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
specific substrate for CatS
-
-
?
(7-[[(2S)-2-(4-[(1S)-1,2-dimethyl-1-[(phenylcarbonyl)amino]propyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid + H2O
?
-
-
-
-
?
(7-[[(2S)-2-(4-[(1S)-1,2-dimethyl-1-[(thiophen-3-ylcarbonyl)amino]propyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid + H2O
?
-
-
-
-
?
(7-[[(2S)-2-(4-[(1S)-1-cyclohexyl-1-[(phenylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid + H2O
?
-
-
-
-
?
(7-[[(2S)-2-(4-[(1S)-1-cyclohexyl-1-[(thiophen-3-ylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid + H2O
?
-
-
-
-
?
10 kDa fragment of the lysosomal MHCII-bound invariant chain + H2O
class II associated invariant chain peptide fragments
-
li p10
-
-
?
Ac-His-Pro-Val-Lys-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O
Ac-His-Pro-Val-Lys + 7-amino-3-carbamoylmethyl-4-methylcoumarin
-
assay at pH 5.5, 37°C
-
-
?
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-L-Val-L-Val-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Val-L-Val-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Leu-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Lys-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Lys + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Phe-Val-Arg-7-amido-4-methylcoumarin
benzyloxycarbonyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Val-Val-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Val-Val-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Val-L-Val-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
Boc-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
Boc-Val-Leu-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
butyloxycarbonyl-L-Phe-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
butyloxycarbonyl-L-Phe-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
cathepsin K + H2O
?
cathepsin S cleaves cathepsin K (cathepsin cannibalism) which reduces the total elastin- and collagen-degradative activity in the multiple cathepsin system
-
-
?
Cbz-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
Cbz-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
CX3CL1 + H2O
?
cathepsin S is able to cleave membrane-anchored CX3CL1, releasing a 55-kDa fragment to the medium
-
-
?
GRWH-norleucine-VGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWH-norleucine-VG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHDVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHDVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHFVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHFVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHGVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHGVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHIVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHIVGL + RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHKVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHKVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHPVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHPVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHT-norleucine-GLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHT-norleucine-G + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTDGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTDG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTFGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTFG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTGGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTGG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTIGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTIG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTKGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTKG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTMGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTMG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTPGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTPG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTTGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTTG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTV-norleucine-LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTV-norleucine + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVDLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVD + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVFLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVF + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVG-citrulline-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + citrulline-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVG-norleucine-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + norleucine-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGFRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + FRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGIRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + IRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGKRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + KRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLDWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LDWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLFWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LFWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLHWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LHWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLIWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LIWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLKWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LKWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLPWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LPWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLQWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LQWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLRDE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LRDE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLRFE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LRFE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLRGE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LRGE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLRHE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LRHE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLRIE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LRIE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLRKE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LRKE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLRRE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + LRRE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
GRWHTVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
specific substrate for CatS
-
-
?
GRWHTVGRRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + RRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVGVRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVG + VRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVILRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVI + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVKLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVK + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVPLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVP + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVQLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVQ + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHTVTLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHTVT + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
GRWHVVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O
GRWHVVG + LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2
-
-
-
-
?
Ii-p10 + H2O
?
-
i.e. MHC classe-associated invariant chain, cathepsin S is the only human cysteine protease able to efficiently degrade the Ii-p10 fragment in epithelial cells
-
-
?
invariant chain + H2O
?
-
invariant chain li is degraded by CatS to the class II-associated invariant chain peptide which dissociates from the MHC-II molecule by forming a complex with the human leucocyte antigen-DM
-
-
?
L-Leu-Leu-Arg-7-amido-4-methylcoumarin + H2O
L-Leu-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
laminin alpha5-chain + H2O
?
the laminin-alpha5-chain is cleaved by CatS specifically at the Ser-Val bond
-
-
?
MHCII-class assosciated invariant chain li + H2O
class II invariant chain peptide fragments
-
-
-
-
?
N-benzyloxycarbonyl-L-Phe-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-Phe-Arg-4-nitroanilide + H2O
N-benzyloxycarbonyl-Phe-Arg + 4-nitroaniline
-
-
-
?
N-[(1S)-1-[1-[(1S)-1-cyanopentyl]-1H-1,2,3-triazol-4-yl]-1,2-dimethylpropyl]benzamide + H2O
?
-
-
-
-
?
o-aminobenzoic acid-Ala-Thr-Pro-Leu-Leu-Met-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-Ala-Thr-Pro-Leu-Leu + Met-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
80% cleavage site, 20% cleavage site: o-aminobenzoic acid-Ala-Thr-Pro-Leu-Leu-Met + Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
?
o-aminobenzoic acid-Gly-Arg-Leu-Asp-Lys-Leu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-Gly-Arg-Leu-Asp + Lys-Leu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
-
-
?
o-aminobenzoic acid-Gly-Phe-Phe-Val-Thr-Thr-Pro-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-Gly-Phe-Phe + Val-Thr-Thr-Pro-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
-
-
?
o-aminobenzoic acid-His-Leu-Val-Glu-Ala-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-His-Leu-Val-Glu + Ala-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
-
-
?
o-aminobenzoic acid-His-Leu-Val-Glu-Ala-Leu-Tyr-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-His-Leu-Val-Glu + Ala-Leu-Tyr-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
56% cleavage site, 44% cleavage site: o-aminobenzoic acid-His-Leu-Val-Glu-Ala-Leu + Tyr-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
?
o-aminobenzoic acid-Leu-Arg-Met-Lys-Leu-Pro-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-Leu-Arg-Met-Lys + Leu-Pro-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
74% cleavage site, 26% cleavage site: o-aminobenzoic acid-Leu-Arg + Met-Lys-Leu-Pro-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
?
o-aminobenzoic acid-Leu-Gln-Leu-Glu-Asn-Leu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-Leu-Gln + Leu-Glu-Asn-Leu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
57% cleavage site, 42% cleavage site: o-aminobenzoic acid-Leu-Gln-Leu-Glu + Asn-Leu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
?
o-aminobenzoic acid-Leu-Glu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-Leu-Glu + Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
-
-
?
o-aminobenzoic acid-Leu-Phe-Glu-Lys-Gln-N-(2,4-dinitrophenyl)ethylendiamine + H2O
o-aminobenzoic acid-Leu-Phe + Glu-Lys-Gln-N-(2,4-dinitrophenyl)ethylendiamine
-
-
-
-
?
o-aminobenzoic acid-Leu-Tyr-Leu-Val-Cys-Gly-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-Leu-Tyr-Leu + Val-Cys-Gly-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
70% cleavage site, 30% cleavage site: o-aminobenzoic acid-Leu-Tyr + Leu-Val-Cys-Gly-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
?
o-aminobenzoic acid-Lys-Pro-Pro-Val-Val-Leu-Leu-Pro-Asp-Gln-N-(2,4-dinitrophenyl)ethylendiamine + H2O
o-aminobenzoic acid-Lys-Pro-Pro-Val-Val-Leu + Leu-Pro-Asp-Gln-N-(2,4-dinitrophenyl)ethylendiamine
-
-
-
-
?
o-aminobenzoic acid-Lys-Pro-Val-Ser-Thr-Glu-Gln-Leu-Ala-Gln-N-(2,4-dinitrophenyl)ethylendiamine + H2O
o-aminobenzoic acid-Lys-Pro-Val-Ser + Thr-Glu-Gln-Leu-Ala-Gln-N-(2,4-dinitrophenyl)ethylendiamine
-
-
-
-
?
o-aminobenzoic acid-Phe-Val-Asn-Gln-His-Leu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-Phe-Val-Asn + Gln-His-Leu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
69% cleavage site, 31% cleavage site: o-aminobenzoic acid-Glu-Val + Asn-Gln-His-Leu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
?
o-aminobenzoic acid-Ser-Arg-His-Ser-Leu-Glu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine) + H2O
o-aminobenzoic acid-Ser-Arg-His-Ser-Leu-Glu + Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
-
-
?
o-aminobenzoic acid-Val-Leu-Phe-Glu-Lys-Gln-N-(2,4-dinitrophenyl)ethylendiamine + H2O
o-aminobenzoic acid-Val-Leu-Phe + Glu-Lys-Gln-N-(2,4-dinitrophenyl)ethylendiamine
-
-
-
-
?
o-aminobenzoic acid-Val-Leu-Phe-Glu-Lys-Lys-Val-Tyr-Leu-Gln-N-(2,4-dinitrophenyl)ethylendiamine + H2O
o-aminobenzoic acid-Val-Leu-Phe-Glu-Lys-Lys-Val-Tyr + Leu-Gln-N-(2,4-dinitrophenyl)ethylendiamine
-
-
-
-
?
Oxidized insulin B-chain + H2O
?
-
major cleavage sites: Glu13-Ala14, Leu17-Val18 and Phe25-Tyr26. Minor cleavage sites: Asn3-Gln4, Ser9-His10 and Leu15-Tyr16
-
-
?
plasminogen + H2O
?
-
-
cleavage occurs at the Leu469-Leu470 peptide bond resulting in 2 fragments: 60000 Da and 38000 Da
-
?
prion protein 94-233 + H2O
prion protein 135-233 + prion protein 117-233 + prion protein 114-233
-
in vitro, enzyme causes specific and limited N-terminal truncation of prion protein 94-233
major soluble fragments, the region of prion protein between S135 and N146 is a major target for selective cleavage cathepsins S
-
?
pro-dipeptidyl peptidase I + H2O
?
-
i.e. cathepsin C, less efficient activation than with cathepsin L
-
-
?
tert-butyloxycarbonyl-Phe-Leu-Arg-7-amido-4-methylcoumarin + H2O
tert-butyloxycarbonyl-Phe-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
tert-butyloxycarbonyl-Phe-Phe-Arg-7-amido-4-methylcoumarin + H2O
tert-butyloxycarbonyl-Phe-Phe-Arg + 7-amino-4-methylcoumarin
Z-Leu-Arg-7-amido-4-methylcoumarin + H2O
Z-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
Z-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Arg-7-amido-4-methylcoumarin + H2O
Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Arg-7-amido-4-methylcoumarin + H2O
Arg + 7-amino-4-methylcoumarin
-
no activity detected
-
-
?
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Val-Val-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Val-Val-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
73% of the activity with benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
Elastin + H2O
?
-
elastolytic enzyme activity of cathepsin S in artherosclerotic lesions, degradation of aortic elastin contributing to atherosclerosis and diabetes
-
-
?
Elastin + H2O
?
-
the enzyme shows distinctive preferences in degrading elastins from bovine neck ligament, aorta, and lung
-
-
?
Ii protein + H2O
Ii fragments
-
inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments
-
-