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Literature summary for 3.4.22.27 extracted from

  • de Nooijer, R.; Bot, I.; von der Thuesen, J.H.; Leeuwenburgh, M.A.; Overkleeft, H.S.; Kraaijeveld, A.O.; Dorland, R.; van Santbrink, P.J.; van Heiningen, S.H.; Westra, M.M.; Kovanen, P.T.; Jukema, J.W.; van der Wall, E.E.; van Berkel, T.J.; Shi, G.P.; Biessen, E.A.
    Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis (2009), Arterioscler. Thromb. Vasc. Biol., 29, 188-194.
    View publication on PubMed
Search for more literature for 3.4.22.27

Activating Compound

Activating Compound Comment Organism Structure
IFN-gamma
-
 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
chimeric LDLr-/-mice deficient in leucocyte cathepsin S are generated by bone marrow transplantation Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CLIK60 selective CatS inhibitor, CatS inhibition increases macrophage cholesterol accumulation and efflux Mus musculus
E64 general cathepsin inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis ?
-
 ?
additional information Mus musculus cathepsin S is an elastolytic enzyme ?
-
 ?
additional information Mus musculus CatS is implicated in the regulation of intracellular cholesterol metabolism ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 leucocyte CatS deficiency leads to a markedly altered plaque morphology and composition, which can in part be attributed to fewer elastic lamina ruptures and a higher resistance of macrophages to apoptosis and necrosis Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis Mus musculus ?
-
 ?
additional information cathepsin S is an elastolytic enzyme Mus musculus ?
-
 ?
additional information CatS is implicated in the regulation of intracellular cholesterol metabolism Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin S
-
 Mus musculus
CatS
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
 CLIK60 CatS activity in RAW264.7 cells or peritoneal macrophages from C57Bl/6 or LDLr-/-mice is completely repressed Mus musculus