Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BMV083 | a near-infrared quenched activity-based probe (qABP) that selectively targets cathepsin S in immune cells | Mus musculus | |
BMV109 | a pan-reactive cysteine cathepsin qABP | Mus musculus | |
BMV117 | a near-infrared quenched activity-based probe (qABP) that selectively targets cathepsin S in immune cells | Mus musculus | |
BMV157 | a near-infrared quenched activity-based probe (qABP) that targets cathepsin S in immune cells | Mus musculus | |
EM053 | a pan-reactive cysteine cathepsin qABP | Mus musculus | |
LO143 | a near-infrared quenched activity-based probe (qABP) that targets cathepsin S in immune cells | Mus musculus | |
LO219 | a near-infrared quenched activity-based probe (qABP) that targets cathepsin S in immune cells | Mus musculus | |
additional information | design and synthesis of a near-infrared quenched activity-based probes (qABP) that selectively target cathepsin S which is highly expressed in immune cells, green-fluorescent pan-reactive cysteine cathepsin qABP in dual color labeling studies in bone marrow-derived immune cells, and identification of vesicles containing exclusively cathepsin S activity, method optimization and evaluation, overview. The high degree of selectivity is retained both in vitro and in vivo | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | design and synthesis of a near-infrared quenched activity-based probes (qABP) that selectively target cathepsin S which is highly expressed in immune cells, green-fluorescent pan-reactive cysteine cathepsin qABP in dual color labeling studies in bone marrow-derived immune cells, and identification of vesicles containing exclusively cathepsin S activity. The high degree of selectivity is retained both in vitro and in vivo | Mus musculus | - |
- |
vesicle | - |
Mus musculus | 31982 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O70370 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Mus musculus | - |
dendritic cell | specific localization of cathepsin S activity in dendritic cells | Mus musculus | - |
intestinal epithelial cell | - |
Mus musculus | - |
leukocyte | bone marrow-derived immune cells, cathepsin S expression is mainly restricted to antigen-presenting cells (APCs) | Mus musculus | - |
macrophage | - |
Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | cathepsin S expression is mainly restricted to antigen-presenting cells (APCs) where it contributes to antigen presenting capacity by controlling trafficking and maturation of major histocompatibility complex (MHC) class II molecules | Mus musculus |