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Literature summary for 3.4.22.27 extracted from

  • Oresic Bender, K.; Ofori, L.; van der Linden, W.A.; Mock, E.D.; Datta, G.K.; Chowdhury, S.; Li, H.; Segal, E.; Sanchez Lopez, M.; Ellman, J.A.; Figdor, C.G.; Bogyo, M.; Verdoes, M.
    Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization (2015), J. Am. Chem. Soc., 137, 4771-4777 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
BMV083 a near-infrared quenched activity-based probe (qABP) that selectively targets cathepsin S in immune cells Mus musculus
BMV109 a pan-reactive cysteine cathepsin qABP Mus musculus
BMV117 a near-infrared quenched activity-based probe (qABP) that selectively targets cathepsin S in immune cells Mus musculus
BMV157 a near-infrared quenched activity-based probe (qABP) that targets cathepsin S in immune cells Mus musculus
EM053 a pan-reactive cysteine cathepsin qABP Mus musculus
LO143 a near-infrared quenched activity-based probe (qABP) that targets cathepsin S in immune cells Mus musculus
LO219 a near-infrared quenched activity-based probe (qABP) that targets cathepsin S in immune cells Mus musculus
additional information design and synthesis of a near-infrared quenched activity-based probes (qABP) that selectively target cathepsin S which is highly expressed in immune cells, green-fluorescent pan-reactive cysteine cathepsin qABP in dual color labeling studies in bone marrow-derived immune cells, and identification of vesicles containing exclusively cathepsin S activity, method optimization and evaluation, overview. The high degree of selectivity is retained both in vitro and in vivo Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information design and synthesis of a near-infrared quenched activity-based probes (qABP) that selectively target cathepsin S which is highly expressed in immune cells, green-fluorescent pan-reactive cysteine cathepsin qABP in dual color labeling studies in bone marrow-derived immune cells, and identification of vesicles containing exclusively cathepsin S activity. The high degree of selectivity is retained both in vitro and in vivo Mus musculus
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vesicle
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Mus musculus 31982
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Organism

Organism UniProt Comment Textmining
Mus musculus O70370
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Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
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Mus musculus
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dendritic cell specific localization of cathepsin S activity in dendritic cells Mus musculus
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intestinal epithelial cell
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Mus musculus
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leukocyte bone marrow-derived immune cells, cathepsin S expression is mainly restricted to antigen-presenting cells (APCs) Mus musculus
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macrophage
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Mus musculus
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RAW-264.7 cell
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Mus musculus
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General Information

General Information Comment Organism
physiological function cathepsin S expression is mainly restricted to antigen-presenting cells (APCs) where it contributes to antigen presenting capacity by controlling trafficking and maturation of major histocompatibility complex (MHC) class II molecules Mus musculus