Application | Comment | Organism |
---|---|---|
diagnostics | an increased serum level of cathepsin S may serve as a biomarker for atherosclerosis and diabetes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cystatin C | endogenous specific inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | serum | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | Homo sapiens | elastolytic enzyme activity of cathepsin S in artherosclerotic lesions, degradation of aortic elastin contributing to atherosclerosis and diabetes | ? | - |
? | |
additional information | Homo sapiens | serum cathepsin S is increased in patients with atherosclerosis and diabetes, the cystatin C level might play a role in disease development, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | increased serum cathepsin S in patients with atherosclerosis and diabetes | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
Cat S activity quantification in serum of healthy persons and atherosclerosis and/or diabetes patients, non-atheroma, and atheroma patients with myocardial infarction, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | elastolytic enzyme activity of cathepsin S in artherosclerotic lesions, degradation of aortic elastin contributing to atherosclerosis and diabetes | Homo sapiens | ? | - |
? | |
Elastin + H2O | degradation, elastolytic enzyme activity of cathepsin S | Homo sapiens | ? | - |
? | |
additional information | serum cathepsin S is increased in patients with atherosclerosis and diabetes, the cystatin C level might play a role in disease development, overview | Homo sapiens | ? | - |
? |