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Literature summary for 3.4.22.27 extracted from

  • Spielmann, N.; Mutch, D.M.; Rousseau, F.; Tores, F.; Hager, J.; Bertrais, S.; Basdevant, A.; Tounian, P.; Dubern, B.; Galan, P.; Clement, K.
    Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations (2008), Clin. Genet., 74, 155-163.
    View publication on PubMed
Search for more literature for 3.4.22.27

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens CTSS is a cysteine protease that has a central role in remodeling the extracellular matrix and it is implicated in the etiology of cardiovascular disease ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P25774 tag single polymorphism at location 147,540,467, intronic A/G exchange
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Homo sapiens P25774 tag single polymorphism at location 147,540,612, exon 4 A/G exchange
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Homo sapiens P25774 tag single polymorphism at location 147,551,270, location at 5'-UTR, T/C exchange
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Homo sapiens P25774 tag single polymorphism at location 147,562,986, genomic C/T exchange
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Homo sapiens P25774 tag single polymorphism at location 47,560,484, genomic T/G exchange
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Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
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 Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 an independent obese adult population, associations between 3 CTSS variants (rs10888390, rs10888394 and rs1136774) and plasma Apo-A1 levels in women are found Homo sapiens
additional information
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 cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations Homo sapiens
additional information
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 CTSS circulating levels are increased in obese individuals and decreased following weight loss induced by gastric surgery Homo sapiens
additional information
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 CTSS contributes independently to plasma Apo-A1 and HDL-Clevels in both healthy and obese populations, with the most prominent CTSS polymorphism (rs10888390) explaining 3.8% of the variance in plasma Apo-A1 phenotype levels in obese women Homo sapiens
additional information
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 CTSS sequence variations are associated with two human metabolic risk factors for cardiovascular diseases, plasma Apo-A1 and HDL-C concentrations Homo sapiens
additional information
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 CTSS sequence variations are associated with two human metabolic risk factors for cardiovascular diseases: plasma Apo-A1 and HDL-C concentrations Homo sapiens
additional information
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 in a lean cohort, which corresponds to a general French population, significant associations between the rs11576175 variant and the plasma Apo-A1 and HDL-C in women and men are identified Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CTSS is a cysteine protease that has a central role in remodeling the extracellular matrix and it is implicated in the etiology of cardiovascular disease Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
cathepsin S
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 Homo sapiens
CTSS
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 Homo sapiens