Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-[4'-(1-azabicyclo[2.2.2]oct-4-yl)-1,1'-biphenyl-3-yl]-N-(cyanomethyl)-4-methylpentanamide | IC50: 1991 nM | Homo sapiens | |
(2R)-2-[4'-(4-tert-butylpiperazin-1-yl)-1,1'-biphenyl-3-yl]-N-(cyanomethyl)-4-methylpentanamide | IC50: 8340 nM | Homo sapiens | |
(2R)-2-[4'-[1-(2-amino-2-methylpropyl)piperidin-4-yl]-1,1'-biphenyl-3-yl]-N-(cyanomethyl)-4-methylpentanamide | IC50: 1427 nM | Homo sapiens | |
(2R)-N-(cyanomethyl)-2-[4'-[4-(2-hydroxy-2-methylpropyl)-1-piperazinyl][1,1'-biphenyl]-3-yl]-4-methylpentanamide | IC50 above 0.01 mM | Homo sapiens | |
(2R)-N-(cyanomethyl)-2-[4'-[4-(2-hydroxyethyl)-1-piperazinyl][1,1'-biphenyl]-3-yl]-4-methylpentanamide | IC50: 609 nM | Homo sapiens | |
(2R)-N-(cyanomethyl)-4-methyl-2-[4'-(1-piperazinyl)-[1,1'-biphenyl]-3-yl]pentanamide | IC50: 2010 nM | Homo sapiens | |
(2R)-N-(cyanomethyl)-4-methyl-2-[4'-(1H-tetraazol-5-yl)-1,1'-biphenyl-3-yl]pentanamide | IC50 above 0.01 mM | Homo sapiens | |
(2R)-N-(cyanomethyl)-4-methyl-2-[4'-(4-methyl-1-piperazinyl)[1,1'-biphenyl]-3-yl]pentanamide | IC50: 3931 nM | Homo sapiens | |
(2R)-N-(cyanomethyl)-4-methyl-2-[4'-(4-pyrimidinyl)[1,1'-biphenyl]-3-yl]pentanamide | IC50: 1365 nM | Homo sapiens | |
(2R)-N-(cyanomethyl)-4-methyl-2-[4'-[4-(2-oxopropyl)-piperazin-1-yl]-1,1'-biphenyl-3-yl]pentanamide | IC50: 2364 nM | Homo sapiens | |
(4S)-N-(cyanomethyl)-4-methyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]hexanamide | IC50 above 0.01 mM | Homo sapiens | |
2-(1,1'-biphenyl-3-yl)-N-(cyanomethyl)-4-methylpentanamide | IC50: 1578 nM | Homo sapiens | |
2-(1,1'-biphenyl-4-yl)-N-(cyanomethyl)-4-methylpentanamide | IC50: 3343 nM | Homo sapiens | |
3'-[1-[[(cyanomethy)amino]carbonyl]-3-methylbutyl]-1,1'biphenyl-4-carboxamide | IC50: 1373 nM | Homo sapiens | |
N-(cyanomethyl)-2-[3-(1H-indol-5-yl)phenyl]-4-methylpentanamide | IC50: 922 nM | Homo sapiens | |
N-(cyanomethyl)-2-[3-(1H-indol-6-yl)phenyl]-4-methylpentanamide | IC50: 1257 nM | Homo sapiens | |
N-(cyanomethyl)-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]-3-phenylpropanamide | IC50 above 0.01 mM | Homo sapiens | |
N-(cyanomethyl)-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]acetamide | IC50 above 0.01 mM | Homo sapiens | |
N-(cyanomethyl)-3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanamide | IC50: 2310 nM | Homo sapiens | |
N-(cyanomethyl)-3-cyclopropyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanamide | IC50: 6597 nM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-(2-phenyl-1,3-thiazol-4-yl)pentanamide | IC50 above 0.01 mM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-(3'-piperazin-1-yl-1,1'-biphenyl-3-yl)pentanamide methanesulfonate | IC50 above 0.01 mM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-(3-pyridin-3-ylphenyl)-pentanamide | IC50 above 0.01 nM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-(3-pyridin-4-ylphenyl)-pentanamide trifluoroacetate | IC50: 1748 nM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-(3-pyrimidin-5-ylphenyl)pentanamide | IC50 above 0.01 mM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-(5-phenylpyridin-3-yl)-pentanamide trifluoroacetate | IC50 above 0.01 mM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-[2'-(1-piperazinyl)[1,1'-biphenyl]-3-yl]pentanamide | IC50: 521 nM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-[2'-(4-morpholinyl)[1,1'-biphenyl]-3-yl]pentanamide | IC50: 3368 nM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-[3'-(4-morpholinyl)[1,1'-biphenyl]-3-yl]pentanamide | IC50 above 0.01 mM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-[4'-(1,2,3,6-tetrahydro-4-pyridinyl)[1,1'-biphenyl]-3-yl]pentanamide | IC50: 652 nM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-[4'-(1-piperazinyl)[1,1'-biphenyl]-3-yl]pentanamide | IC50: 1245 nM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-[4'-(4-methyl-1-piperazinyl)[1,1'-biphenyl]-3-yl]pentanamide | IC50: 1695 nM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-[4'-(4-morpholinyl)[1,1'-biphenyl]-3-yl]pentanamide | IC50: 9422 nM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-[4'-(4-piperidinyl)[1,1'-biphenyl]-3-yl]pentanamide | IC50: 1421 nM | Homo sapiens | |
N-(cyanomethyl)-4-methyl-2-[4'-(methylsulfonyl)-1,1'-biphenyl-3-yl]pentanamide | IC50: 6623 nM | Homo sapiens | |
N2-benzoyl-N1-(cyanomethyl)-L-leucinamide | IC50: 41 nM | Homo sapiens | |
tert-butyl 4-[3'-[1-[[(cyanomethyl)amino]carbonyl]-3-methylbutyl]-1,1'-biphenyl-4-yl]piperazine-1-carboxylate | IC50: 1298 nM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000001 | - |
IC50 above 0.01 nM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-(3-pyridin-3-ylphenyl)-pentanamide | |
0.000041 | - |
IC50: 41 nM | Homo sapiens | N2-benzoyl-N1-(cyanomethyl)-L-leucinamide | |
0.000521 | - |
IC50: 521 nM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-[2'-(1-piperazinyl)[1,1'-biphenyl]-3-yl]pentanamide | |
0.000609 | - |
IC50: 609 nM | Homo sapiens | (2R)-N-(cyanomethyl)-2-[4'-[4-(2-hydroxyethyl)-1-piperazinyl][1,1'-biphenyl]-3-yl]-4-methylpentanamide | |
0.000652 | - |
IC50: 652 nM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-[4'-(1,2,3,6-tetrahydro-4-pyridinyl)[1,1'-biphenyl]-3-yl]pentanamide | |
0.000922 | - |
IC50: 922 nM | Homo sapiens | N-(cyanomethyl)-2-[3-(1H-indol-5-yl)phenyl]-4-methylpentanamide | |
0.001245 | - |
IC50: 1245 nM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-[4'-(1-piperazinyl)[1,1'-biphenyl]-3-yl]pentanamide | |
0.001257 | - |
IC50: 1257 nM | Homo sapiens | N-(cyanomethyl)-2-[3-(1H-indol-6-yl)phenyl]-4-methylpentanamide | |
0.001298 | - |
IC50: 1298 nM | Homo sapiens | tert-butyl 4-[3'-[1-[[(cyanomethyl)amino]carbonyl]-3-methylbutyl]-1,1'-biphenyl-4-yl]piperazine-1-carboxylate | |
0.001365 | - |
IC50: 1365 nM | Homo sapiens | (2R)-N-(cyanomethyl)-4-methyl-2-[4'-(4-pyrimidinyl)[1,1'-biphenyl]-3-yl]pentanamide | |
0.001373 | - |
IC50: 1373 nM | Homo sapiens | 3'-[1-[[(cyanomethy)amino]carbonyl]-3-methylbutyl]-1,1'biphenyl-4-carboxamide | |
0.001421 | - |
IC50: 1421 nM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-[4'-(4-piperidinyl)[1,1'-biphenyl]-3-yl]pentanamide | |
0.001427 | - |
IC50: 1427 nM | Homo sapiens | (2R)-2-[4'-[1-(2-amino-2-methylpropyl)piperidin-4-yl]-1,1'-biphenyl-3-yl]-N-(cyanomethyl)-4-methylpentanamide | |
0.001578 | - |
IC50: 1578 nM | Homo sapiens | 2-(1,1'-biphenyl-3-yl)-N-(cyanomethyl)-4-methylpentanamide | |
0.001695 | - |
IC50: 1695 nM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-[4'-(4-methyl-1-piperazinyl)[1,1'-biphenyl]-3-yl]pentanamide | |
0.001748 | - |
IC50: 1748 nM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-(3-pyridin-4-ylphenyl)-pentanamide trifluoroacetate | |
0.001991 | - |
IC50: 1991 nM | Homo sapiens | (2R)-2-[4'-(1-azabicyclo[2.2.2]oct-4-yl)-1,1'-biphenyl-3-yl]-N-(cyanomethyl)-4-methylpentanamide | |
0.00201 | - |
IC50: 2010 nM | Homo sapiens | (2R)-N-(cyanomethyl)-4-methyl-2-[4'-(1-piperazinyl)-[1,1'-biphenyl]-3-yl]pentanamide | |
0.00231 | - |
IC50: 2310 nM | Homo sapiens | N-(cyanomethyl)-3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanamide | |
0.002364 | - |
IC50: 2364 nM | Homo sapiens | (2R)-N-(cyanomethyl)-4-methyl-2-[4'-[4-(2-oxopropyl)-piperazin-1-yl]-1,1'-biphenyl-3-yl]pentanamide | |
0.003343 | - |
IC50: 3343 nM | Homo sapiens | 2-(1,1'-biphenyl-4-yl)-N-(cyanomethyl)-4-methylpentanamide | |
0.003368 | - |
IC50: 3368 nM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-[2'-(4-morpholinyl)[1,1'-biphenyl]-3-yl]pentanamide | |
0.003931 | - |
IC50: 3931 nM | Homo sapiens | (2R)-N-(cyanomethyl)-4-methyl-2-[4'-(4-methyl-1-piperazinyl)[1,1'-biphenyl]-3-yl]pentanamide | |
0.006597 | - |
IC50: 6597 nM | Homo sapiens | N-(cyanomethyl)-3-cyclopropyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanamide | |
0.006623 | - |
IC50: 6623 nM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-[4'-(methylsulfonyl)-1,1'-biphenyl-3-yl]pentanamide | |
0.00834 | - |
IC50: 8340 nM | Homo sapiens | (2R)-2-[4'-(4-tert-butylpiperazin-1-yl)-1,1'-biphenyl-3-yl]-N-(cyanomethyl)-4-methylpentanamide | |
0.009422 | - |
IC50: 9422 nM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-[4'-(4-morpholinyl)[1,1'-biphenyl]-3-yl]pentanamide | |
0.01 | - |
IC50 above 0.01 mM | Homo sapiens | (2R)-N-(cyanomethyl)-2-[4'-[4-(2-hydroxy-2-methylpropyl)-1-piperazinyl][1,1'-biphenyl]-3-yl]-4-methylpentanamide | |
0.01 | - |
IC50 above 0.01 mM | Homo sapiens | (2R)-N-(cyanomethyl)-4-methyl-2-[4'-(1H-tetraazol-5-yl)-1,1'-biphenyl-3-yl]pentanamide | |
0.01 | - |
IC50 above 0.01 mM | Homo sapiens | (4S)-N-(cyanomethyl)-4-methyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]hexanamide | |
0.01 | - |
IC50 above 0.01 mM | Homo sapiens | N-(cyanomethyl)-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]acetamide | |
0.01 | - |
IC50 above 0.01 mM | Homo sapiens | N-(cyanomethyl)-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]-3-phenylpropanamide | |
0.01 | - |
IC50 above 0.01 mM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-(2-phenyl-1,3-thiazol-4-yl)pentanamide | |
0.01 | - |
IC50 above 0.01 mM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-(3'-piperazin-1-yl-1,1'-biphenyl-3-yl)pentanamide methanesulfonate | |
0.01 | - |
IC50 above 0.01 mM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-(3-pyrimidin-5-ylphenyl)pentanamide | |
0.01 | - |
IC50 above 0.01 mM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-(5-phenylpyridin-3-yl)-pentanamide trifluoroacetate | |
0.01 | - |
IC50 above 0.01 mM | Homo sapiens | N-(cyanomethyl)-4-methyl-2-[3'-(4-morpholinyl)[1,1'-biphenyl]-3-yl]pentanamide |