Literature summary for 3.4.22.27 extracted from

Novinec, M.; Grass, R.N.; Stark, W.J.; Turk, V.; Baici, A.; Lenarcic, B.
Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors (2007), J. Biol. Chem., 282, 7893-7902.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli strain BL21 (DE3)	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
E-64	irreversible inhibitor	Homo sapiens
kininogen domain 3	-	Homo sapiens
p41 fragment	-	Homo sapiens
Stefin A	-	Homo sapiens
Tg1 domain of testican-1	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0125	-	benzyloxycarbonyl-Phe-Val-Arg-7-amido-4-methylcoumarin	in 50 mM sodium phosphate buffer, pH 6.5, containing 2.5 mM EDTA and 0.1% PEG-6000	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	benzyloxycarbonyl-Phe-Val-Arg + 7-amino-4-methylcoumarin	-	?
Elastin + H2O	the enzyme shows distinctive preferences in degrading elastins from bovine neck ligament, aorta, and lung	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)