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Literature summary for 3.4.22.27 extracted from

  • Shi, G.P.; Munger, J.S.; Meara, J.P.; Rich, D.H.; Chapman, H.A.
    Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease (1992), J. Biol. Chem., 267, 7258-7262.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Benzyloxycarbonyl-Phe-Phe-CHN2 0.001 mM, 98% inhibition Homo sapiens
benzyloxycarbonyl-Tyr-Ala-CHN2 0.001 mM, 88% inhibition Homo sapiens
benzyloxycarbonyl-Tyr-Tyr(O-butyl)-CHN2 1 mM, 78% inhibition Homo sapiens
cystatin 0.001 mM, complete inhibition Homo sapiens
E-64 0.001 mM, 96% inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme may contribute to the contact-dependent elastase activity of live human alveolar macrophages ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the cDNA predicts a 331-amino acid prepro-cathepsin S Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
alveolar macrophage
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme may contribute to the contact-dependent elastase activity of live human alveolar macrophages Homo sapiens ?
-
?