Literature summary for 3.4.22.27 extracted from

Dekita, M.; Wu, Z.; Ni, J.; Zhang, X.; Liu, Y.; Yan, X.; Nakanishi, H.; Takahashi, I.
Cathepsin S is involved in Th17 differentiation through the upregulation of IL-6 by activating PAR-2 after systemic exposure to lipopolysaccharide from Porphyromonas gingivalis (2017), Front. Pharmacol., 8, 470 .

Search for more literature for 3.4.22.27

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of enzyme knockout CatS-/- mice	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Mus musculus	5764	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O70370	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
dendritic cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
CatS	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	the population of CD11c+ dendritic cells is significantly increased in the splenic marginal zone (MZ) locally of wild-type (DBA/2) mice with splenomegaly but not in that of CatS deficient (CatS-/-) mice after systemic exposure to lipopolysaccharide from Porphyromonas gingivalis (PgLPS) for 7 consecutive days	Mus musculus
physiological function	cathepsin S (CatS) is involved in Th17 differentiation through the upregulation of interleukin-6 by activating PAR-2 after systemic exposure to lipopolysaccharide from Porphyromonas gingivalis (PgLPS). Lysosomal proteinase CatS is known to be involved in dendritic cell functions. CatS is essential for the production of interleukin-6 by splenic CD11cC dendritic cells after systemic exposure to PgLPS	Mus musculus

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Release 2023.1 (January 2023)