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Literature summary for 3.4.22.27 extracted from
- Radiation-induced cathepsin S is involved in radioresistance (2009), Int. J. Cancer, 124, 1794-1801.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| As2O3 | produces reactive oxygen species, also induces CatS expression | Homo sapiens |  |
| bleomycin | produces reactive oxygen species, also induces CatS expression | Homo sapiens | |
| H2O2 | produces reactive oxygen species, also induces CatS expression | Homo sapiens | |
| interferon-gamma | - |
Homo sapiens | |
| additional information | treatment with taxol and cisplatin do not induces CatS expression | Homo sapiens | |
| radiation | radiation induced production of CatS at both the mRNA and protein level and increased its protease activity, that IFN regulatory factor-1 is the critical transcriptional mediator of interferon-gamma-dependent CatS production after radiation, treatment with as little as 0.5 Gy of radiation induces CatS mRNA, the highest levels are induced in response to treatment with 10 Gy of radiation | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| wild type human CatS is cloned into pcDNA3, CatS overexpression is involved in radioresistance | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 24000 | - |
activated CatS is a single chain polypeptide | Homo sapiens |
| 36000 | - |
inactive precursor | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | CatS is capable of degrading a range of extracellular matrix macromolecules | ? | - |
? | |
| additional information | Homo sapiens | CatS is identified as a compound involved in MHC class II maturation and trafficking within antigen presentation pathways, as well as in the control of processing antigens and the formation of peptide-receptive class II dimers | ? | - |
? | |
| Val-Val-Arg + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MCF-10A cell | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
| NCI-H460 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | CatS is capable of degrading a range of extracellular matrix macromolecules | Homo sapiens | ? | - |
? | |
| additional information | CatS is identified as a compound involved in MHC class II maturation and trafficking within antigen presentation pathways, as well as in the control of processing antigens and the formation of peptide-receptive class II dimers | Homo sapiens | ? | - |
? | |
| Val-Val-Arg + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cathepsin S | - |
Homo sapiens |
| CatS | - |
Homo sapiens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
CatS is markedly more stable at extracellular pH, which indicates that it may play a role in extracellular proteolysis | Homo sapiens |
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