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Literature summary for 3.4.22.27 extracted from

  • Shaw, E.; Mohanty, S.; Colic, A.; Stoka, V.; Turk, V.
    The affinity-labelling of cathepsin S with peptidyl diazomethyl ketones. Comparison with the inhibition of cathepsin L and calpain (1993), FEBS Lett., 334, 340-342.
    View publication on PubMed
Search for more literature for 3.4.22.27

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-((CH3)3C-CH(NH2)-COOH)-Tyr-CHN2 t1/2 at 0.1 mM is 1.6 min Bos taurus
benzyloxycarbonyl-((CH3)3C-CH2-CH(NH2)-COOH)-Leu-Tyr-CHN2 t1/2 at 0.0004 mM is 3.85 min Bos taurus
benzyloxycarbonyl-Ile-Met-CHN2 t1/2 at 0.001 mM is 5.4 min Bos taurus
benzyloxycarbonyl-Ile-Trp-CHN2 t1/2 at 0.004 mM is 3.45 min Bos taurus
benzyloxycarbonyl-Leu-Ala-CHN2 t1/2 at 0.0001 mM is 5.5 min Bos taurus
benzyloxycarbonyl-Leu-Leu-CHN2 t1/2 at 0.00002 mM is 8.6 min Bos taurus
benzyloxycarbonyl-Leu-Leu-Nle-CHN2 t1/2 at 0.000001 mM is 1.25 min Bos taurus
benzyloxycarbonyl-Leu-Leu-Tyr-CHN2 t1/2 at 0.000001 mM is 5.5 min Bos taurus
benzyloxycarbonyl-Leu-Nle-CHN2 t1/2 at 0.00001 mM is 3.4 min Bos taurus
benzyloxycarbonyl-Leu-Nva-CHN2 t1/2 at 0.00001 mM is 4.5 min Bos taurus
benzyloxycarbonyl-Leu-Thr(tert-butyl)-CHN2 t1/2 at 0.001 mM is 3.5 min Bos taurus
benzyloxycarbonyl-Leu-Trp-CHN2 t1/2 at 0.0002 mM is 2.6 min Bos taurus
Benzyloxycarbonyl-Phe-Phe-CHN2 t1/2 at 0.001 mM is 6.4 min Bos taurus
benzyloxycarbonyl-Phe-Tyr(tert-butyl)CHN2 t1/2 at 0.02 mM is 19.25 min, about 10000times more effective against cathepsin L than against cathepsin S Bos taurus
benzyloxycarbonyl-Trp-Met-CHN2 t1/2 at 0.00001 mM is 3.0 min Bos taurus
benzyloxycarbonyl-Val-Met-CHN2 t1/2 at 0.0001 mM is 3.5 min Bos taurus
benzyloxycarbonyl-Val-Nle-CHN2 t1/2 at 0.00003 mM is 5.8 min Bos taurus
benzyloxycarbonyl-Val-Trp-Nle-CHN2 t1/2 at 0.00001 mM is 5.7 min Bos taurus
benzyloxycarbonyl-Val-Val-CHN2 t1/2 at 0.0001 mM is 47.0 min Bos taurus
benzyloxycarbonyl-Val-Val-Nle-CHN2 t1/2 at 0.000001 is 2.5 min, 300times more effective in inactivating cathepsin S than cathepsin L Bos taurus
benzyloxycarbonyl-Val-Val-Tyr-CHN2 t1/2 at 0.000005 mM is 6.75 min Bos taurus
butyloxycarbonyl-Lys-Leu-Tyr-CHN2 t1/2 at 0.0001 mM is 2.9 min Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
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