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Information on EC 2.1.1.355 - [histone H3]-lysine9 N-trimethyltransferase

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IUBMB Comments
This entry describes several enzymes that successively methylate the L-lysine9 residue of histone H3 (H3K9), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes.
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Word Map
  • 2.1.1.355
  • chromatin
  • trimethylation
  • heterochromatin
  • polycomb
  • zeste
  • h3k9me3
  • deacetylase
  • hp1
  • demethylase
  • nucleosomes
  • euchromatic
  • variegation
  • reprogramming
  • self-renewal
  • epigenome
  • deacetylation
  • hdacs
  • suvar3-9
  • chromatin-modifying
  • trithorax
  • hypermethylation
  • dnmt3a
  • corepressors
  • intellectual
  • domain-containing
  • histone-modifying
  • pericentric
  • chromodomain
  • monomethylation
  • homeotic
  • h3k9ac
  • prdm16
  • chromatin-remodeling
  • chip-seq
  • prc1
  • microdeletion
  • bromodomains
  • telomeres
  • mixed-lineage
  • analysis
  • di-methylation
  • menin
  • non-histone
  • lys4
  • leukemogenesis
  • chromatin-associated
  • writer
  • polytene
  • subtelomeric
  • medicine
  • centromeres
  • pericentromeric
The enzyme appears in viruses and cellular organisms
Synonyms
dG9a, Dim-5, Dim-5 histone lysine methyltransferase, Dim-5 histone-3 lysine-9 methyltransferase, EHMT1, EHMT2, ESET, G9a, G9a histone methyltransferase, G9a lysine 9 histone H3 methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
show the reaction diagram
overall reaction
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S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
show the reaction diagram
(1a)
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S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
show the reaction diagram
(1c)
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S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
show the reaction diagram
(1b)
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S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
show the reaction diagram
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