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Literature summary for 2.1.1.355 extracted from

  • Brower-Toland, B.; Riddle, N.C.; Jiang, H.; Huisinga, K.L.; Elgin, S.C.
    Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster (2009), Genetics, 181, 1303-1319.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Drosophila melanogaster 5634
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adult
-
 Drosophila melanogaster
-
head
-
 Drosophila melanogaster
-
larva
-
 Drosophila melanogaster
-
pupa
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone H3(K9)
-
 Drosophila melanogaster ?
-
 ?

Synonyms

Synonyms Comment Organism
G9a
-
 Drosophila melanogaster
H3K9 methyltransferase
-
 Drosophila melanogaster
H3K9-specific SET domain methyltransferase
-
 Drosophila melanogaster
SETDB1
-
 Drosophila melanogaster
SU(VAR)3-9
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction knockdown of G9a or SETDB1 throughout development with an ACT5C-GAL4 driver produces organism- level defects only in the case of dSETDB1 Drosophila melanogaster
physiological function SETDB1 acts to maintain heterochromatin during metamorphosis, at a later stage in development than the reported action of SU(VAR)3-9, depletion of both of these enzymes has less deleterious effect than depletion of one, SETDB1 acts as a heterochromatin maintenance factor that may be required for the persistence of earlier developmental events normally governed by SU(VAR)3-9 Drosophila melanogaster