Reference on EC 2.1.1.355 - [histone H3]-lysine9 N-trimethyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tachibana, M.; Sugimoto, K.; Nozaki, M.; Ueda, J.; Ohta, T.; Ohki, M.; Fukuda, M.; Takeda, N.; Niida, H.; Kato, H.; Shinkai, Y.
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
Genes Dev.
16
1779-1791
2002
Mus musculus
Yeates, T.O.
Structures of SET domain proteins: protein lysine methyltransferases make their mark
Cell
111
5-7
2002
Neurospora crassa
Nishio, H.; Walsh, M.J.
CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription
Proc. Natl. Acad. Sci. USA
101
11257-11262
2004
Homo sapiens
Gowher, H.; Zhang, X.; Cheng, X.; Jeltsch, A.
Avidin plate assay system for enzymatic characterization of a histone lysine methyltransferase
Anal. Biochem.
342
287-291
2005
Neurospora crassa
Chin, H.G.; Pradhan, M.; Esteve, P.O.; Patnaik, D.; Evans, T.C.; Pradhan, S.
Sequence specificity and role of proximal amino acids of the histone H3 tail on catalysis of murine G9A lysine 9 histone H3 methyltransferase
Biochemistry
44
12998-13006
2005
Mus musculus
Chen, H.; Yan, Y.; Davidson, T.L.; Shinkai, Y.; Costa, M.
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
Cancer Res.
66
9009-9016
2006
Homo sapiens, Mus musculus
Lee, D.Y.; Northrop, J.P.; Kuo, M.H.; Stallcup, M.R.
Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors
J. Biol. Chem.
281
8476-8485
2006
Mus musculus
Duan, Z.; Zarebski, A.; Montoya-Durango, D.; Grimes, H.L.; Horwitz, M.
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1
Mol. Cell. Biol.
25
10338-10351
2005
Homo sapiens
Eom, G.H.; Kim, K.; Kim, S.M.; Kee, H.J.; Kim, J.Y.; Jin, H.M.; Kim, J.R.; Kim, J.H.; Choe, N.; Kim, K.B.; Lee, J.; Kook, H.; Kim, N.; Seo, S.B.
Histone methyltransferase PRDM8 regulates mouse testis steroidogenesis
Biochem. Biophys. Res. Commun.
388
131-136
2009
Mus musculus
Rathert, P.; Zhang, X.; Freund, C.; Cheng, X.; Jeltsch, A.
Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays
Chem. Biol.
15
5-11
2008
Neurospora crassa
Dong, K.B.; Maksakova, I.A.; Mohn, F.; Leung, D.; Appanah, R.; Lee, S.; Yang, H.W.; Lam, L.L.; Mager, D.L.; Schuebeler, D.; Tachibana, M.; Shinkai, Y.; Lorincz, M.C.
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity
EMBO J.
27
2691-2701
2008
Mus musculus
Brower-Toland, B.; Riddle, N.C.; Jiang, H.; Huisinga, K.L.; Elgin, S.C.
Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster
Genetics
181
1303-1319
2009
Drosophila melanogaster
Chen, X.; El Gazzar, M.; Yoza, B.K.; McCall, C.E.
The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance
J. Biol. Chem.
284
27857-27865
2009
Homo sapiens
Thomas, L.R.; Miyashita, H.; Cobb, R.M.; Pierce, S.; Tachibana, M.; Hobeika, E.; Reth, M.; Shinkai, Y.; Oltz, E.M.
Functional analysis of histone methyltransferase G9a in B and T lymphocytes
J. Immunol.
181
485-493
2008
Mus musculus
Wagschal, A.; Sutherland, H.; Woodfine, K.; Henckel, A.; Chebli, K.; Schulz, R.; Oakey, R.; Bickmore, W.; Feil, R.
G9a histone methyltransferase contributes to imprinting in the mouse placenta
Mol. Cell. Biol.
28
1104-1113
2008
Mus musculus
Chang, Y.; Zhang, X.; Horton, J.R.; Upadhyay, A.K.; Spannhoff, A.; Liu, J.; Snyder, J.P.; Bedford, M.T.; Cheng, X.
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
Nat. Struct. Mol. Biol.
16
312-317
2009
Homo sapiens
Ushijima, Y.; Inoue, Y.H.; Konishi, T.; Kitazawa, D.; Yoshida, H.; Shimaji, K.; Kimura, H.; Yamaguchi, M.
Roles of histone H3K9 methyltransferases during Drosophila spermatogenesis
Chromosome Res.
20
319-331
2012
Drosophila melanogaster
Gupta-Agarwal, S.; Franklin, A.V.; Deramus, T.; Wheelock, M.; Davis, R.L.; McMahon, L.L.; Lubin, F.D.
G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation
J. Neurosci.
32
5440-5453
2012
Rattus norvegicus
Veiseth, S.V.; Rahman, M.A.; Yap, K.L.; Fischer, A.; Egge-Jacobsen, W.; Reuter, G.; Zhou, M.M.; Aalen, R.B.; Thorstensen, T.
The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in Arabidopsis
PLoS Genet.
7
e1001325
2011
Arabidopsis thaliana
Lu, Z.; Tian, Y.; Salwen, H.R.; Chlenski, A.; Godley, L.A.; Raj, J.U.; Yang, Q.
Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells
Anticancer Drugs
24
484-493
2013
Homo sapiens
Imai, K.; Kamio, N.; Cueno, M.E.; Saito, Y.; Inoue, H.; Saito, I.; Ochiai, K.
Role of the histone H3 lysine 9 methyltransferase Suv39 h1 in maintaining Epstein-Barr virus latency in B95-8 cells
FEBS J.
281
2148-2158
2014
Homo sapiens (O43463)
Chiba, T.; Saito, T.; Yuki, K.; Zen, Y.; Koide, S.; Kanogawa, N.; Motoyama, T.; Ogasawara, S.; Suzuki, E.; Ooka, Y.; Tawada, A.; Otsuka, M.; Miyazaki, M.; Iwama, A.; Yokosuka, O.
Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma
Int. J. Cancer
136
289-298
2015
Homo sapiens (O43463), Homo sapiens (Q15047), Homo sapiens
Hsiao, S.M.; Chen, M.W.; Chen, C.A.; Chien, M.H.; Hua, K.T.; Hsiao, M.; Kuo, M.L.; Wei, L.H.
The H3K9 methyltransferase G9a represses E-cadherin and is associated with myometrial invasion in endometrial cancer
Ann. Surg. Oncol.
22
S1556-S1565
2015
Homo sapiens
Xue, W.; Huang, J.; Chen, H.; Zhang, Y.; Zhu, X.; Li, J.; Zhang, W.; Yuan, Y.; Wang, Y.; Zheng, L.; Huang, K.
Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1
Biochim. Biophys. Acta
1864
338-346
2018
Homo sapiens (Q96KQ7)
Zhang, Y.; Xue, W.; Zhang, W.; Yuan, Y.; Zhu, X.; Wang, Q.; Wei, Y.; Yang, D.; Yang, C.; Chen, Y.; Sun, Y.; Wang, S.; Huang, K.; Zheng, L.
Histone methyltransferase G9a protects against acute liver injury through GSTP1
Cell Death Differ.
27
1243-1258
2019
Mus musculus (Q9Z148), Mus musculus
Au Yeung, W.K.; BrindAmour, J.; Hatano, Y.; Yamagata, K.; Feil, R.; Lorincz, M.C.; Tachibana, M.; Shinkai, Y.; Sasaki, H.
Histone H3K9 methyltransferase G9a in oocytes is essential for preimplantation development but dispensable for CG methylation protection
Cell Rep.
27
282-293.e4
2019
Mus musculus (Q9Z148), Mus musculus
Papait, R.; Serio, S.; Pagiatakis, C.; Rusconi, F.; Carullo, P.; Mazzola, M.; Salvarani, N.; Miragoli, M.; Condorelli, G.
Histone methyltransferase G9a is required for cardiomyocyte homeostasis and hypertrophy
Circulation
136
1233-1246
2017
Mus musculus (Q9Z148), Mus musculus
Gu, Q.; Ji, T.; Sun, X.; Huang, H.; Zhang, H.; Lu, X.; Wu, L.; Huo, R.; Wu, H.; Gao, X.
Histone H3 lysine 9 methyltransferase FvDim5 regulates fungal development, pathogenicity and osmotic stress responses in Fusarium verticillioides
FEMS Microbiol. Lett.
364
fnx184
2017
Fusarium verticillioides (W7MCU7), Fusarium verticillioides, Fusarium verticillioides 7600 (W7MCU7)
Casciello, F.; Windloch, K.; Gannon, F.; Lee, J.S.
Functional role of G9a histone methyltransferase in cancer
Front. Immunol.
6
487
2015
Mus musculus (Q9Z148)
Zhang, X.; Liu, X.; Zhao, Y.; Cheng, J.; Xie, J.; Fu, Y.; Jiang, D.; Chen, T.
Histone H3 lysine 9 methyltransferase DIM5 is required for the development and virulence of Botrytis cinerea
Front. Microbiol.
7
1289
2016
Botrytis cinerea (A0A384JX50), Botrytis cinerea, Botrytis cinerea B05.10 (A0A384JX50)
Jang, S.; Kang, C.; Yang, H.S.; Jung, T.; Hebert, H.; Chung, K.Y.; Kim, S.J.; Hohng, S.; Song, J.J.
Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase
Genes Dev.
33
620-625
2019
Homo sapiens (Q8TEK3)
Jin, W.; Shang, Y.; Peng, J.; Jiang, S.
Histone H3 methyltransferase Suv39h1 prevents myogenic terminal differentiation by repressing MEF2 activity in muscle cells
Int. J. Mol. Sci.
17
1908
2016
Mus musculus (O54864)
Tachibana, M.; Sugimoto, K.; Fukushima, T.; Shinkai, Y.
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3
J. Biol. Chem.
276
25309-25317
2001
Homo sapiens (Q96KQ7)
Xiong, Y.; Li, F.; Babault, N.; Dong, A.; Zeng, H.; Wu, H.; Chen, X.; Arrowsmith, C.H.; Brown, P.J.; Liu, J.; Vedadi, M.; Jin, J.
Discovery of potent and selective inhibitors for G9a-like protein (GLP) lysine methyltransferase
J. Med. Chem.
60
1876-1891
2017
Homo sapiens (Q96KQ7)
Mueller, M.M.; Fierz, B.; Bittova, L.; Liszczak, G.; Muir, T.W.
A two-state activation mechanism controls the histone methyltransferase Suv39h1
Nat. Chem. Biol.
12
188-193
2016
Homo sapiens (O43463), Homo sapiens
Smolko, A.E.; Shapiro-Kulnane, L.; Salz, H.K.
The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
Nat. Commun.
9
4155
2018
Drosophila melanogaster, Drosophila melanogaster (Q32KD2)
Akoury, E.; Ma, G.; Demolin, S.; Broenner, C.; Zocco, M.; Cirilo, A.; Ivic, N.; Halic, M.
Disordered region of H3K9 methyltransferase Clr4 binds the nucleosome and contributes to its activity
Nucleic Acids Res.
47
6726-6736
2019
Schizosaccharomyces pombe
Wojtala, M.; Macierzynska-Piotrowska, E.; Rybaczek, D.; Pirola, L.; Balcerczyk, A.
Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells
Pharmacol. Res.
128
252-263
2018
Homo sapiens (Q96KQ7), Homo sapiens
Riahi, H.; Brekelmans, C.; Foriel, S.; Merkling, S.H.; Lyons, T.A.; Itskov, P.M.; Kleefstra, T.; Ribeiro, C.; van Rij, R.P.; Kramer, J.M.; Schenck, A.
The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption
PLoS Biol.
17
e2006146
2019
Drosophila melanogaster
Ishimoto, K.; Kawamata, N.; Uchihara, Y.; Okubo, M.; Fujimoto, R.; Gotoh, E.; Kakinouchi, K.; Mizohata, E.; Hino, N.; Okada, Y.; Mochizuki, Y.; Tanaka, T.; Hamakubo, T.; Sakai, J.; Kodama, T.; Inoue, T.; Tachibana, K.; Doi, T.
Ubiquitination of lysine 867 of the human SETDB1 protein upregulates its histone H3 lysine 9 (H3K9) methyltransferase activity
PLoS ONE
11
e0165766
2016
Homo sapiens (Q15047), Homo sapiens
Ho, J.C.; Abdullah, L.N.; Pang, Q.Y.; Jha, S.; Chow, E.K.; Yang, H.; Kato, H.; Poellinger, L.; Ueda, J.; Lee, K.L.
Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway
PLoS ONE
12
e0188051
2017
Homo sapiens (Q96KQ7)
Hachiya, R.; Shiihashi, T.; Shirakawa, I.; Iwasaki, Y.; Matsumura, Y.; Oishi, Y.; Nakayama, Y.; Miyamoto, Y.; Manabe, I.; Ochi, K.; Tanaka, M.; Goda, N.; Sakai, J.; Suganami, T.; Ogawa, Y.
The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages
Sci. Rep.
6
28845
2016
Mus musculus (Q96KQ7)
Pinheiro, I.; Margueron, R.; Shukeir, N.; Eisold, M.; Fritzsch, C.; Richter, F.M.; Mittler, G.; Genoud, C.; Goyama, S.; Kurokawa, M.; Son, J.; Reinberg, D.; Lachner, M.; Jenuwein, T.
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity
Cell
150
948-960
2012
Mus musculus (O54864)
Fritsch, L.; Robin, P.; Mathieu, J.R.; Souidi, M.; Hinaux, H.; Rougeulle, C.; Harel-Bellan, A.; Ameyar-Zazoua, M.; Ait-Si-Ali, S.
A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex
Mol. Cell
37
46-56
2010
Homo sapiens (O43463)
Tzeng, T.Y.; Lee, C.H.; Chan, L.W.; Shen, C.K.
Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1
Proc. Natl. Acad. Sci. USA
104
12691-12696
2007
Drosophila melanogaster (Q32KD2), Drosophila melanogaster
html completed
