Literature summary for 2.1.1.355 extracted from

Lu, Z.; Tian, Y.; Salwen, H.R.; Chlenski, A.; Godley, L.A.; Raj, J.U.; Yang, Q.
Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells (2013), Anticancer Drugs, 24, 484-493.

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Application

Application	Comment	Organism
medicine	treatment with inhibitor BIX-01294 specifically decreases global H3K9Me2 level but not H3K27Me2. The inhibition of EHMT2 decreases proliferation of NB cells and induces apoptosis by increasing caspase 8/caspase 3 activity. BIX-01294 inhibits NB cell mobility and invasion accompanied with a decreased expression of the MYCN oncogene. Inhibition of EHMT2 enhances a doxorubicin induced inhibitory effect on cell proliferation and modulates global DNA methylation levels in NB cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
BIX-01294	specific inhibitor of isoform EHMT2, specifically decreases global H3K9Me2 level but not H3K27Me2. The inhibition of EHMT2 decreases proliferation of NB cells and induces apoptosis by increasing caspase 8/caspase 3 activity. BIX-01294 inhibits NB cell mobility and invasion accompanied with a decreased expression of the MYCN oncogene. Inhibition of EHMT2 enhances a doxorubicin induced inhibitory effect on cell proliferation and modulates global DNA methylation levels in NB cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
IMR-5 cell	-	Homo sapiens	-
LA1-55n cell	-	Homo sapiens	-
NMB cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
EHMT2	-	Homo sapiens

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Release 2023.1 (January 2023)