Any feedback?
Literature summary for 2.1.1.355 extracted from
- Role of the histone H3 lysine 9 methyltransferase Suv39 h1 in maintaining Epstein-Barr virus latency in B95-8 cells (2014), FEBS J., 281, 2148-2158.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chaetocin | specific isoform Suv39 h1 inhibitor | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O43463 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SUV39H1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the SET domain of isoformn Suv39 h1 is essential for repressing gene expression of BZLF1, which acts as a master regulator of the transition from latency to the lytic replication cycle in latently Epstein-Barr virus-infected cells. Depletion of Suv39 h1 protein by siRNA results in increased expression of BZLF1 mRNA in B958 cells, and Suv39 h1 inhibitor chaetocin activates BZLF1 transcription | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
