Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q96KQ7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Mus musculus | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 180000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
ESET | - |
Mus musculus |
H3K9 methyltransferase | - |
Mus musculus |
SETDB1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | macrophage-specific enzyme-knockout mice exhibit higher serum interleukin-6 concentrations in response to lipopolysaccharide challenge and are more susceptible to endotoxin shock than wild type mice. Enzyme deficiency increases nuclear factor-kappaB p65 recruitment to the interleukin 6 promoter | Mus musculus |
physiological function | the enzyme regulates toll-like receptor 4-mediated inflammatory responses in macrophages. The enzyme is an epigenetic regulator of proinflammatory cytokine expression in macrophages. The enzyme suppresses transcriptional activity of interleukin 6 promoter | Mus musculus |