Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BIX-01294 | diazepin-quinazolin-amine derivative, specific competitive inhibitor | Mus musculus | |
UNC0638 | - |
Mus musculus | |
UNC0642 | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Mus musculus | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
r | |
additional information | Mus musculus | the enzyme is automethylated at K239 | ? | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Mus musculus | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9 | - |
r | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | Mus musculus | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
r | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 | Mus musculus | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | - |
r | |
S-adenosyl-L-methionine + ACINUS | Mus musculus | - |
? | - |
? | |
S-adenosyl-L-methionine + CDYL1 | Mus musculus | - |
? | - |
? | |
S-adenosyl-L-methionine + p53 | Mus musculus | the enzyme is responsible for p53 methylation at lysine 373 | ? | - |
? | |
S-adenosyl-L-methionine + reptin | Mus musculus | the enzyme is responsible for reptin methylation at lysine 67 | ? | - |
? | |
S-adenosyl-L-methionine + WIZ | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9Z148 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | overall reaction | Mus musculus | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
r | |
additional information | the enzyme is automethylated at K239 | Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | - |
Mus musculus | S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9 | - |
r | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | - |
Mus musculus | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
r | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 | - |
Mus musculus | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | - |
r | |
S-adenosyl-L-methionine + ACINUS | - |
Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + CDYL1 | - |
Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + p53 | the enzyme is responsible for p53 methylation at lysine 373 | Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + reptin | the enzyme is responsible for reptin methylation at lysine 67 | Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + WIZ | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EHMT2 | - |
Mus musculus |
G9a | - |
Mus musculus |
H3K9 methyltransferase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the enzyme is overexpressed in a number of cancers, including esophageal squamous cell carcinoma, hepato-cellular carcinoma, aggressive lung cancer, brain cancer, multiple myeloma, and aggressive ovarian carcinoma | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme depletion results in embryonic lethality with severe differentiation defects in embryonic stem cells. Enzyme depletion inhibits cell proliferation in several cancer cell lines | Mus musculus |
physiological function | the enzyme is essential for the repression of developmental genes and is required during development | Mus musculus |