Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BIX-01294 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Homo sapiens | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96KQ7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | overall reaction | Homo sapiens | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G9a | - |
Homo sapiens |
H3K9 methyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition attenuates oncogenicity and activates the hypoxia signaling pathway | Homo sapiens |
physiological function | the enzyme is a key mediator of oncogenic processes in breast cancer cells | Homo sapiens |