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Rice jmjC domain-containing gene JMJ706 encodes H3K9 demethylase required for floral organ development
2008
Sun, Q.; Zhou, D.
Proc. Natl. Acad. Sci. USA
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Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family
2011
Hillringhaus, L.; Yue, W.W.; Rose, N.R.; Ng, S.S.; Gileadi, C.; Loenarz, C.; Bello, S.H.; Bray, J.E.; Schofield, C.J.; Oppermann, U.
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Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
2011
Shi, L.; Sun, L.; Li, Q.; Liang, J.; Yu, W.; Yi, X.; Yang, X.; Li, Y.; Han, X.; Zhang, Y.; Xuan, C.; Yao, Z.; Shang, Y.
Proc. Natl. Acad. Sci. USA
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The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations
2017
Hancock, R.L.; Masson, N.; Dunne, K.; Flashman, E.; Kawamura, A.
ACS Chem. Biol.
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4-biphenylalanine- and 3-phenyltyrosine-derived hydroxamic acids as inhibitors of the JumonjiC-domain-containing histone demethylase KDM4A
2016
Morera, L.; Roatsch, M.; Fuerst, M.C.; Hoffmann, I.; Senger, J.; Hau, M.; Franz, H.; Schuele, R.; Heinrich, M.R.; Jung, M.
ChemMedChem
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4-biphenylalanine- and 3-phenyltyrosine-derived hydroxamic acids as inhibitors of the JumonjiC-domain-containing histone demethylase KDM4A
2016
Morera, L.; Roatsch, M.; Fuerst, M.C.; Hoffmann, I.; Senger, J.; Hau, M.; Franz, H.; Schuele, R.; Heinrich, M.R.; Jung, M.
ChemMedChem
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Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development
2016
Pedersen, M.T.; Kooistra, S.M.; Radzisheuskaya, A.; Laugesen, A.; Johansen, J.V.; Hayward, D.G.; Nilsson, J.; Agger, K.; Helin, K.
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Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development
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The histone H3K9 demethylase Kdm3b is required for somatic growth and female reproductive function
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Int. J. Biol. Sci.
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The histone H3K9 demethylase Kdm3b is required for somatic growth and female reproductive function
2015
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8-Substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors
2016
Bavetsias, V.; Lanigan, R.M.; Ruda, G.F.; Atrash, B.; McLaughlin, M.G.; Tumber, A.; Mok, N.Y.; Le Bihan, Y.V.; Dempster, S.; Boxall, K.J.; Jeganathan, F.; Hatch, S.B.; Savitsky, P.; Velupillai, S.; Krojer, T.; England, K.S.; Sejberg, J.; Thai, C.; Donovan, A.; Pal, A.; Scozzafava, G.; Bennett, J.M.; Kawamu, A.
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KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans
2015
Gacek-Matthews, A.; Noble, L.M.; Gruber, C.; Berger, H.; Sulyok, M.; Marcos, A.T.; Strauss, J.; Andrianopoulos, A.
Mol. Microbiol.
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KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans
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KDM4C, a H3K9me3 histone demethylase, is involved in the maintenance of human ESCC-initiating cells by epigenetically enhancing SOX2 expression
2016
Yuan, X.; Kong, J.; Ma, Z.; Li, N.; Jia, R.; Liu, Y.; Zhou, F.; Zhan, Q.; Liu, G.; Gao, S.
Neoplasia
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KDM4C, a H3K9me3 histone demethylase, is involved in the maintenance of human ESCC-initiating cells by epigenetically enhancing SOX2 expression
2016
Yuan, X.; Kong, J.; Ma, Z.; Li, N.; Jia, R.; Liu, Y.; Zhou, F.; Zhan, Q.; Liu, G.; Gao, S.
Neoplasia
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RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation
2014
Zoabi, M.; Nadar-Ponniah, P.T.; Khoury-Haddad, H.; Usaj, M.; Budowski-Tal, I.; Haran, T.; Henn, A.; Mandel-Gutfreund, Y.; Ayoub, N.
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KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis
2014
Kupershmit, I.; Khoury-Haddad, H.; Awwad, S.W.; Guttmann-Raviv, N.; Ayoub, N.
Nucleic Acids Res.
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KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis
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Kupershmit, I.; Khoury-Haddad, H.; Awwad, S.W.; Guttmann-Raviv, N.; Ayoub, N.
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The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1
2014
Tee, A.E.; Ling, D.; Nelson, C.; Atmadibrata, B.; Dinger, M.E.; Xu, N.; Mizukami, T.; Liu, P.Y.; Liu, B.; Cheung, B.; Pasquier, E.; Haber, M.; Norris, M.D.; Suzuki, T.; Marshall, G.M.; Liu, T.
Oncotarget
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The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1
2014
Tee, A.E.; Ling, D.; Nelson, C.; Atmadibrata, B.; Dinger, M.E.; Xu, N.; Mizukami, T.; Liu, P.Y.; Liu, B.; Cheung, B.; Pasquier, E.; Haber, M.; Norris, M.D.; Suzuki, T.; Marshall, G.M.; Liu, T.
Oncotarget
5
1793-1804
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372
2017
An, J.; Xu, J.; Li, J.; Jia, S.; Li, X.; Lu, Y.; Yang, Y.; Lin, Z.; Xin, X.; Wu, M.; Zheng, Q.; Pu, H.; Gui, X.; Li, T.; Lu, D.
Oncotarget
8
49093-49109
JMJ27, an Arabidopsis H3K9 histone demethylase, modulates defense against Pseudomonas syringae and flowering time
2017
Dutta, A.; Choudhary, P.; Caruana, J.; Raina, R.
Plant J.
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JMJ27, an Arabidopsis H3K9 histone demethylase, modulates defense against Pseudomonas syringae and flowering time
2017
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Histone H3K9 demethylase JMJD2B activates adipogenesis by regulating H3K9 methylation on PPARgamma and C/EBPalpha during adipogenesis
2017
Jang, M.K.; Kim, J.H.; Jung, M.H.
PLoS ONE
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Identification of non-histone substrates for JMJD2A-C histone demethylases
2009
Ponnaluri, V.; Vavilala, D.; Putty, S.; Gutheil, W.; Mukherji, M.
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Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer
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Li, W.; Zhao, L.; Zang, W.; Liu, Z.; Chen, L.; Liu, T.; Xu, D.; Jia, J.
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Histone modifying enzymes structures, mechanisms, and specificities
2009
Marmorstein, R.; Trievel, R.C.
Biochim. Biophys. Acta
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The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility
2011
Iwamori, N.; Zhao, M.; Meistrich, M.L.; Matzuk, M.M.
Biol. Reprod.
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The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility
2011
Iwamori, N.; Zhao, M.; Meistrich, M.L.; Matzuk, M.M.
Biol. Reprod.
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Alterations of histone modifications by cobalt compounds
2009
Li, Q.; Ke, Q.; Costa, M.
Carcinogenesis
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Alterations of histone modifications by cobalt compounds
2009
Li, Q.; Ke, Q.; Costa, M.
Carcinogenesis
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KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors
2013
Black, J.C.; Manning, A.L.; Van Rechem, C.; Kim, J.; Ladd, B.; Cho, J.; Pineda, C.M.; Murphy, N.; Daniels, D.L.; Montagna, C.; Lewis, P.W.; Glass, K.; Allis, C.D.; Dyson, N.J.; Getz, G.; Whetstine, J.R.
Cell
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Histone demethylase JmjD2A regulates neural crest specification
2010
Strobl-Mazzulla, P.H.; Sauka-Spengler, T.; Bronner-Fraser, M.
Dev. Cell
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The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila
2009
Lorbeck, M.T.; Singh, N.; Zervos, A.; Dhatta, M.; Lapchenko, M.; Yang, C.; Elefant, F.
Gene
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The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila
2009
Lorbeck, M.T.; Singh, N.; Zervos, A.; Dhatta, M.; Lapchenko, M.; Yang, C.; Elefant, F.
Gene
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Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
2007
Loh, Y.H.; Zhang, W.; Chen, X.; George, J.; Ng, H.H.
Genes Dev.
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SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation
2011
Tan, M.K.; Lim, H.J.; Harper, J.W.
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Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase
2007
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The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
2006
Klose, R.J.; Yamane, K.; Bae, Y.; Zhang, D.; Erdjument-Bromage, H.; Tempst, P.; Wong, J.; Zhang, Y.
Nature
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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
2007
Ng, S.S.; Kavanagh, K.L.; McDonough, M.A.; Butler, D.; Pilka, E.S.; Lienard, B.M.; Bray, J.E.; Savitsky, P.; Gileadi, O.; von Delft, F.; Rose, N.R.; Offer, J.; Scheinost, J.C.; Borowski, T.; Sundstrom, M.; Schofield, C.J.; Oppermann, U.
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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
2007
Ng, S.S.; Kavanagh, K.L.; McDonough, M.A.; Butler, D.; Pilka, E.S.; Lienard, B.M.; Bray, J.E.; Savitsky, P.; Gileadi, O.; von Delft, F.; Rose, N.R.; Offer, J.; Scheinost, J.C.; Borowski, T.; Sundstrom, M.; Schofield, C.J.; Oppermann, U.
Nature
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Functional analysis of histone demethylase Jmjd2b on lipopolysaccharide-treated murine neural stem cells (NSCs)
2013
Das, N.D.; Choi, M.R.; Jung, K.H.; Park, J.H.; Lee, H.T.; Das, A.; Kim, S.H.; Chai, Y.G.
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Functional analysis of histone demethylase Jmjd2b on lipopolysaccharide-treated murine neural stem cells (NSCs)
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Neurotox. Res.
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Characterization of Drosophila melanogaster JmjC+N histone demethylases
2008
Lloret-Llinares, M.; Carre, C.; Vaquero, A.; de Olano, N.; Azorin, F.
Nucleic Acids Res.
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Characterization of Drosophila melanogaster JmjC+N histone demethylases
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Nucleic Acids Res.
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A new isoform of the histone demethylase JMJD2A/KDM4A is required for skeletal muscle differentiation
2011
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PLoS Genet.
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Structural basis of the recognition of a methylated histone tail by JMJD2A
2007
Chen, Z.; Zang, J.; Kappler, J.; Hong, X.; Crawford, F.; Wang, Q.; Lan, F.; Jiang, C.; Whetstine, J.; Dai, S.; Hansen, K.; Shi, Y.; Zhang, G.
Proc. Natl. Acad. Sci. USA
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The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression
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The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression
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The role of histone demethylase GASC1 in cancer and its therapeutic potential
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Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice
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Genes Cells
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Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice
2016
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Genes Cells
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JHDM3A module as an effector molecule in guide-directed modification of target chromatin
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Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses
2019
Jiang, Y.; Li, C.; Wu, Q.; An, P.; Huang, L.; Wang, J.; Chen, C.; Chen, X.; Zhang, F.; Ma, L.; Liu, S.; He, H.; Xie, S.; Sun, Y.; Liu, H.; Zhan, Y.; Tao, Y.; Liu, Z.; Sun, X.; Hu, Y.; Wang, Q.; Ye, D.; Zhang, J.; Zou, S.; Wang, Y.; Wei, G.; Liu, Y.; Shi, Y.; Eugene Chin, Y.; Hao, Y.; Wang, F.; Zhang, X.
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PLoS ONE
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Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling
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Histone H3K9 demethylase JMJD2B induces hepatic steatosis through upregulation of PPARgamma2
2018
Kim, J.H.; Jung, D.Y.; Nagappan, A.; Jung, M.H.
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Histone H3K9 demethylase JMJD2B induces hepatic steatosis through upregulation of PPARgamma2
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Kim, J.H.; Jung, D.Y.; Nagappan, A.; Jung, M.H.
Sci. Rep.
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Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to define a pluripotency gene regulatory network
2021
Zhu, Z.; Wu, X.; Li, Q.; Zhang, J.; Yu, S.; Shen, Q.; Zhou, Z.; Pan, Q.; Yue, W.; Qin, D.; Zhang, Y.; Zhao, W.; Zhang, R.; Peng, S.; Li, N.; Zhang, S.; Lei, A.; Miao, Y.L.; Liu, Z.; Chen, X.; Wang, H.; Liao, M.; Hua, J.
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Kim, Y.J.; Lee, D.H.; Choi, Y.S.; Jeong, J.H.; Kwon, S.H.
Int. J. Mol. Sci.
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Histone H3K9 demethylase JMJD2B plays a role in LXRalpha-dependent lipogenesis
2020
Kim, J.H.; Jung, D.Y.; Kim, H.R.; Jung, M.H.
Int. J. Mol. Sci.
21
8313
Histone demethylase JMJD2B/KDM4B regulates transcriptional program via distinctive epigenetic targets and protein interactors for the maintenance of trophoblast stem cells
2021
Mak, K.; Lam, Y.; Ng, R.
Sci. Rep.
11
884
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