Literature summary for 2.1.1.355 extracted from

Riahi, H.; Brekelmans, C.; Foriel, S.; Merkling, S.H.; Lyons, T.A.; Itskov, P.M.; Kleefstra, T.; Ribeiro, C.; van Rij, R.P.; Kramer, J.M.; Schenck, A.
The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption (2019), PLoS Biol., 17, e2006146 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9	Drosophila melanogaster	overall reaction	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9	overall reaction	Drosophila melanogaster	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9	-	?

Synonyms

Synonyms	Comment	Organism
G9a	-	Drosophila melanogaster
H3K9 methyltransferase	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
malfunction	during oxidative stress exposure, enzyme mutants show overactivation of stress response genes, rapid depletion of glycogen, and inability to access lipid energy stores	Drosophila melanogaster
physiological function	the enzyme acts as a critical regulatory hub between the transcriptional and metabolic responses to oxidative stress	Drosophila melanogaster

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Release 2023.1 (January 2023)