Literature summary for 2.1.1.355 extracted from

Duan, Z.; Zarebski, A.; Montoya-Durango, D.; Grimes, H.L.; Horwitz, M.
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1 (2005), Mol. Cell. Biol., 25, 10338-10351.

Search for more literature for 2.1.1.355

Application

Application	Comment	Organism
additional information	growth factor independent 1 interacts with G9a and recruits G9a and histone deacetylase 1 to its target promoters, including the cell cycle regulator p21Cip/WAF1 and other cell cycle regulators, in order to repress transcription through histone H3(K9) dimethylation	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
cotransfection of growth factor independent 1 with both HA epitope-tagged G9a and Myc epitope-tagged Suv39H1 into HeLa cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	interaction between growth factor independent 1 and G9a in vivo	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	growth factor independent 1 and G9a complex methylates the wild-type H3 substrate as well as the mutants replaced at K4, K36, and K79, substitution at K27 slightly reduces methylation of the H3 substrate, whereas substitution at K9 blocks methylation	Homo sapiens	?	-	?
S-adenosyl-L-methionine + histone H3(K9)	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
histone lysine methyltransferase G9a	-	Homo sapiens

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Release 2023.1 (January 2023)