Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic stem cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + histone L-lysine | - |
Mus musculus | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H3K9 histone methyltransferases | - |
Mus musculus |
histone lysine methyltransferase | - |
Mus musculus |
HMTase | - |
Mus musculus |
lysine methyltransferase G9a | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | embryonic stem cells lacking the H3K9 HMTase G9a show a significant reduction in DNA methylation of retrotransposons, major satellite repeats and densely methylated CpG-rich promoters | Mus musculus |
physiological function | DNA methylation of retrotransposons in embryonic stem cells requires the lysine methyltransferase G9a but not its catalytic activity | Mus musculus |