Reference on EC 6.2.1.3 - long-chain-fatty-acid-CoA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hartman, E.J.; Omura, S.; Laposata, M.
Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase
Prostaglandins
37
655-671
1989
Mus musculus
Gerritsen, M.E.; Perry, C.A.
Regulation of eicosanoid synthesis in microvessel endothelium: glucocorticoids do not affect arachidonyl CoA synthetase activity
Biochim. Biophys. Acta
1045
174-179
1990
Oryctolagus cuniculus
Bakken, A.M.; Farstad, M.
Identical subcellular distribution of palmitoyl-CoA and arachidonoyl-CoA synthetase activities in human blood platelets
Biochem. J.
261
71-76
1989
Homo sapiens
Bakken, A.M.; Farstad, M.; Holmsen, H.
Identity between palmitoyl-CoA synthetase and arachidonoyl-CoA synthetase in human platelets?
Biochem. J.
274
145-152
1991
Homo sapiens
Coleman, R.A.; Rao, P.; Fogelsong, R.J.; Bardes, E.S.G.
2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes
Biochim. Biophys. Acta
1125
203-209
1992
Rattus norvegicus
Suzuki, H.; Kawarabayashi, Y.; Kondo, J.; Abe, T.; Hishikawa, K.; Kimura, S.; Hashimoto, T.; Yamamoto, T.
Structure and regulation of rat long-chain acyl-CoA synthetase
J. Biol. Chem.
265
8681-8685
1990
Rattus norvegicus
Hurtado del Catalfo, G.E.; De Gomez Dumm, I.N.T.; Mandon, E.C.
Long chain acyl-CoA synthetase of rat testis microsomes. Substrate specificity and hormonal regulation
Biochem. Mol. Biol. Int.
31
643-649
1993
Rattus norvegicus
Vanden Heuvel, J.P.; Kuslikis, B.I.; Shrago, E.; Peterson, R.E.
Inhibition of long-chain acyl-CoA synthetase by the peroxisome proliferator perfluorodecanoic acid in rat hepatocytes
Biochem. Pharmacol.
42
295-302
1991
Rattus norvegicus
Knights, K.M.; Jones, M.E.
Inhibition kinetics of hepatic microsomal long chain fatty acid-CoA ligase by 2-arylpropionic acid non-steroidal anti-inflammatory drugs
Biochem. Pharmacol.
43
1465-1471
1992
Rattus norvegicus
Wanders, R.J.A.; Denis, S.; Roermund, C.W.T.; Jakobs, C.; ten Brink, H.J.
Characteristics and subcellular localization of pristanoyl-CoA synthetase in rat liver
Biochim. Biophys. Acta
1125
274-279
1992
Rattus norvegicus
Black, P.N.; Zhang, Q.; Weimar, J.D.; DiRusso, C.C.
Mutational analysis of a fatty acyl-coenzyme A synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity
J. Biol. Chem.
272
4896-4903
1997
Escherichia coli
Fujino, T.; Kang, M.J.; Suzuki, H.; Iijima, H.; Yamamoto, T.
Molecular characterization and expression of rat acyl-CoA synthetase 3
J. Biol. Chem.
271
16748-16752
1996
Rattus norvegicus (Q63151)
Tomoda, H.; Igarashi, K.; Cyong, J.C.; Omura, S.
Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation
J. Biol. Chem.
266
4214-4219
1991
Homo sapiens
Kalish, J.E.; Chen, C.I.; Gould, S.J.; Watkins, P.A.
Peroxisomal activation of long- and very long-chain fatty acids in the yeast Pichia pastoris
Biochem. Biophys. Res. Commun.
206
335-340
1995
Komagataella pastoris
Black, P.N.; DiRusso, C.C.; Metzger, A.K.; Heimert, T.L.
Cloning, sequencing, and expression of the fadD gene of Escherichia coli encoding acyl coenzyme A synthetase
J. Biol. Chem.
267
25513-25520
1992
Escherichia coli
Duronio, R.J.; Knoll, L.J.; Gordon, J.I.
Isolation of a Saccharomyces cerevisiae long chain fatty acyl:CoA synthetase gene (FAA1) and assessment of its role in protein N-myristoylation
J. Cell Biol.
117
515-529
1992
Saccharomyces cerevisiae
Olsen, J.A.; Huang, A.H.C.
Glyoxysomal acyl-CoA synthetase and oxidase from germinating elm, rape and maize seed
Phytochemistry
27
1601-1603
1988
Brassica napus, Ulmus sp., Zea mays
-
Thomas, D.R.; Wood, C.; Masterson, C.
Long-chain acyl CoA synthetase, carnitine and beta-oxidation in the pea-seed mitochondrion
Planta
173
263-266
1988
Pisum sativum
Beaumelle, B.D.; Vial, H.J.
Acyl-CoA synthetase activity in Plasmodium knowlesi-infected erythrocytes displays peculiar substrate specificities
Biochim. Biophys. Acta
958
1-9
1988
Plasmodium knowlesi
Tomoda, H.; Igarashi, K.; Omura, S.
Inhibition of acyl-CoA synthetase by triacsins
Biochim. Biophys. Acta
921
595-598
1987
Pseudomonas aeruginosa, Rattus norvegicus
Haq, R.U.; Tsao, F.; Shrago, E.
Activity of long chain acyl-CoA synthetase in isolated alveolar type II cells
Biochim. Biophys. Acta
918
36-39
1987
Rattus norvegicus
Morisaki, N.; Kanzaki, T.; Saito, Y.; Yoshida, S.
Fatty acid specificity of acyl-CoA synthetase in rat glomeruli
Biochim. Biophys. Acta
875
311-315
1986
Rattus norvegicus
Kameda, K.; Imai, Y.
Isolation and characterization of the multiple charge isoforms of acyl-CoA synthetase from Escherichia coli
Biochim. Biophys. Acta
832
343-350
1985
Escherichia coli
Miyazawa, S.; Hashimoto, T.; Yokota, S.
Identity of long-chain acyl-coenzyme A synthetase of microsomes, mitochondria, and peroxisomes in rat liver
J. Biochem.
98
723-733
1985
Rattus norvegicus
Kameda, K.; Suzuki, L.K.; Imai, Y.
Further purification, characterization and salt activation of acyl-CoA synthetase from Escherichia coli
Biochim. Biophys. Acta
840
29-36
1985
Escherichia coli
Noy, N.; Zakim, D.
Substrate specificity of fatty-acyl-CoA ligase in liver microsomes
Biochim. Biophys. Acta
833
239-244
1985
Rattus norvegicus
Reddy, T.S.; Sprecher, H.; Bazan, N.G.
Long-chain acyl-coenzyme A synthetase from rat liver brain microsomes. Kinetic studies using [1-14C]docosahexaenoic acid substrate
Eur. J. Biochem.
145
21-29
1984
Rattus norvegicus
Normann, P.T.; Norseth, J.; Flatmark, T.
Acyl-CoA synthetase activity of rat heart mitochondria. Substrate specificity with special reference to very-long-chain and isomeric fatty acids
Biochim. Biophys. Acta
752
474-481
1983
Rattus norvegicus
Mannaerts, G.P.; Van Veldhoven, P.; Van Broekhoven, A.; Vanderbroek, C.; Debeer, L.J.
Evidence that peroxisomal acyl-CoA synthetase is located at the cytoplasmic side of the peroxisomal membrane
Biochem. J.
204
17-23
1982
Rattus norvegicus
Tanaka, T.; Hosaka, K.; Numa, S.
Long-chain acyl-CoA synthetase from rat liver
Methods Enzymol.
71
334-341
1981
Rattus norvegicus
Hosaka, K.; Mishina, M.; Kamiryo, T.; Numa, S.
Long-chain acyl-CoA synthetase I and II from Candida lipolytica
Methods Enzymol.
71
325-333
1981
Yarrowia lipolytica
-
Normann, P.T.; Thomassen, M.S.; Christiansen, E.N.; Flatmark, T.
Acyl-CoA synthetase activity of rat liver microsomes. Substrate specificity with special reference to very-long-chain and isomeric fatty acids
Biochim. Biophys. Acta
664
416-427
1981
Rattus norvegicus
Kameda, K.; Nunn, W.D.
Purification and characterization of acyl coenzyme A synthetase from Escherichi coli
J. Biol. Chem.
256
5702-5707
1981
Escherichia coli
Philipp, D.P.; Parsons, P.
Kinetic characterization of long chain fatty acyl coenzyme A ligase from rat liver mitochondria
J. Biol. Chem.
254
10785-10790
1979
Rattus norvegicus
-
Philipp, D.P.; Parsons, P.
Isolation and purification of long chain fatty acyl coenzyme A ligase from rat liver mitochondria
J. Biol. Chem.
254
10776-10784
1979
Rattus norvegicus
Tanaka, T.; Hosaka, M.; Hoshimaru, M.; Numa, S.
Purification and properties of long-chain acyl-coenzyme -A synthetase from rat liver
Eur. J. Biochem.
98
165-172
1979
Rattus norvegicus
Marcel, Y.L.; Suzue, G.
Kinetic studies on the specificity of long chain acyl coenzyme A synthetase from rat liver microsomes
J. Biol. Chem.
247
4433-4436
1972
Rattus norvegicus
Moriya-Sato, A.; Hida, A.; Inagawa-Ogashiwa, M.; Wada, M.R.; Sugiyama, K.; Shimizu, J.; Yabuki, T.; Seyama, Y.; Hashimoto, N.
Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues
Biochem. Biophys. Res. Commun.
279
62-68
2000
Mus musculus
Jiang, D.W.; Englund, P.T.
Four Trypanosoma brucei fatty acyl-CoA synthetases: fatty acid specificity of the recombinant proteins
Biochem. J.
358
757-761
2001
Trypanosoma brucei
Brugger, R.; Reichel, C.; Garcia Alia, B.; Brune, K.; Yamamoto, T.; Tegeder, I.; Geissinger, G.
Expression of rat liver long-chain acyl-CoA synthetase and characterization of its role in the metabolism of R-ibuprofen and other fatty acid-like xenobiotics
Biochem. Pharmacol.
61
651-656
2001
Rattus norvegicus
Uberti, M.A.; Pierce, J.; Weis, M.T.
Molecular characterization of a rabbit long-chain fatty acyl CoA synthetase that is highly expressed in the vascular endothelium
Biochim. Biophys. Acta
1645
193-204
2003
Oryctolagus cuniculus
Kim, J.H.; Lewin, T.M.; Coleman, R.A.
Expression and characterization of recombinant rat acyl-CoA synthetases 1, 4, and 5: selective inhibition by triacsin C and thiazolidinediones
J. Biol. Chem.
276
24667-24673
2001
Rattus norvegicus
Lewin, T.M.; Kim, J.H.; Granger, D.A.; Vance, J.E.; Coleman, R.A.
Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently
J. Biol. Chem.
276
24674-24679
2001
Rattus norvegicus
Weimar, J.D.; DiRusso, C.C.; Delio, R.; Black, P.N.
Functional role of fatty acyl-coenzyme A synthetase in the transmembrane movement and activation of exogenous long-chain fatty acids: Amino acid residues within the ATP/AMP signature motif of Escherichia coli FadD are required for enzyme activity and fatty acid transport
J. Biol. Chem.
277
29369-29376
2002
Escherichia coli
Pongdontri, P.; Hills, M.
Characterization of a novel plant acyl-coA synthetase that is expressed in lipogenic tissues of Brassica napus L
Plant Mol. Biol.
47
717-726
2001
Brassica napus (Q9FNT6)
Tang, P.Z.; Tsai-Morris, C.H.; Dufau, M.L.
Cloning and characterization of a hormonally regulated rat long chain acyl-CoA synthetase
Proc. Natl. Acad. Sci. USA
98
6581-6586
2001
Rattus norvegicus (Q924N5)
Oba, Y.; Sato, M.; Ojika, M.; Inouye, S.
Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase
Biosci. Biotechnol. Biochem.
69
819-828
2005
Luciola cruciata, Photinus pyralis
Oba, Y.; Ojika, M.; Inouye, S.
Firefly luciferase is a bifunctional enzyme: ATP-dependent monooxygenase and a long chain fatty acyl-CoA synthetase
FEBS Lett.
540
251-254
2003
Luciola cruciata, Photinus pyralis
Qiao, S.; Tuohimaa, P.
The role of long-chain fatty-acid-CoA ligase 3 in vitamin D3 and androgen control of prostate cancer LNCaP cell growth
Biochem. Biophys. Res. Commun.
319
358-368
2004
Homo sapiens
Van Horn, C.G.; Caviglia, J.M.; Li, L.O.; Wang, S.; Granger, D.A.; Coleman, R.A.
Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6
Biochemistry
44
1635-1642
2005
Rattus norvegicus (P33124)
Achouri, Y.; Hegarty, B.D.; Allanic, D.; Becard, D.; Hainault, I.; Ferre, P.; Foufelle, F.
Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c
Biochimie
87
1149-1155
2005
Rattus norvegicus
Grove, T.J.; Sidell, B.D.
Fatty acyl CoA synthetase from Antarctic notothenioid fishes may influence substrate specificity of fat oxidation
Comp. Biochem. Physiol. B
139
53-63
2004
Chaenocephalus aceratus, Notothenia coriiceps
Sheng, Y.; Li, J.; Dufau, M.L.; Tsai-Morris, C.H.
The gonadotropin-regulated long-chain acyl CoA synthetase gene: a novel downstream Sp1/Sp3 binding element critical for transcriptional promoter activity
Gene
360
20-26
2005
Mus musculus
Vessey, D.A.; Kelley, M.; Warren, R.S.
Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver
J. Biochem. Mol. Toxicol.
18
100-106
2004
Homo sapiens
Caviglia, J.M.; Li, L.O.; Wang, S.; DiRusso, C.C.; Coleman, R.A.; Lewin, T.M.
Rat long chain acyl-CoA synthetase 5, but not 1, 2, 3, or 4, complements Escherichia coli fadD
J. Biol. Chem.
279
11163-11169
2004
Rattus norvegicus, Rattus norvegicus (Q63151)
Marszalek, J.R.; Kitidis, C.; Dararutana, A.; Lodish, H.F.
Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth
J. Biol. Chem.
279
23882-23891
2004
Rattus norvegicus (P33124)
Schmelter, T.; Trigatti, B.L.; Gerber, G.E.; Mangroo, D.
Biochemical demonstration of the involvement of fatty acyl-CoA synthetase in fatty acid translocation across the plasma membrane
J. Biol. Chem.
279
24163-24170
2004
Escherichia coli
Hisanaga, Y.; Ago, H.; Nakagawa, N.; Hamada, K.; Ida, K.; Yamamoto, M.; Hori, T.; Arii, Y.; Sugahara, M.; Kuramitsu, S.; Yokoyama, S.; Miyano, M.
Structural basis of the substrate-specific two-step catalysis of long chain fatty acyl-CoA synthetase dimer
J. Biol. Chem.
279
31717-31726
2004
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Marszalek, J.R.; Kitidis, C.; Dirusso, C.C.; Lodish, H.F.
Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism
J. Biol. Chem.
280
10817-10826
2005
Rattus norvegicus
Hall, A.M.; Wiczer, B.M.; Herrmann, T.; Stremmel, W.; Bernlohr, D.A.
Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice
J. Biol. Chem.
280
11948-11954
2005
Mus musculus
Mashek, D.G.; McKenzie, M.A.; Van Horn, C.G.; Coleman, R.A.
Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglcyerol in McArdle-RH7777 cells
J. Biol. Chem.
281
945-950
2005
Rattus norvegicus, Rattus norvegicus (O88813)
Richards, M.R.; Harp, J.D.; Ory, D.S.; Schaffer, J.E.
Fatty acid transport protein 1 and long chain acyl CoA synthetase 1 interact in adipocytes
J. Lipid Res.
47
665-672
2005
Mus musculus
Jiang, D.W.; Werbovetz, K.A.; Varadhachary, A.; Cole, R.N.; Englund, P.T.
Purification and identification of a fatty acyl-CoA synthetase from Trypanosoma brucei
Mol. Biochem. Parasitol.
135
149-152
2004
Trypanosoma brucei, Trypanosoma brucei 427
Wang, Y.L.; Guo, W.; Zang, Y.; Yaney, G.C.; Vallega, G.; Getty-Kaushik, L.; Pilch, P.; Kandror, K.; Corkey, B.E.
Acyl coenzyme a synthetase regulation: putative role in long-chain acyl coenzyme a partitioning
Obes. Res.
12
1781-1788
2004
Rattus norvegicus
Fulda, M.; Schnurr, J.; Abbadi, A.; Heinz, E.; Browse, J.
Peroxisomal Acyl-CoA synthetase activity is essential for seedling development in Arabidopsis thaliana
Plant Cell
16
394-405
2004
Arabidopsis thaliana
Schnurr, J.; Shockey, J.; Browse, J.
The acyl-CoA synthetase encoded by LACS2 is essential for normal cuticle development in Arabidopsis
Plant Cell
16
629-642
2004
Arabidopsis thaliana
Tonon, T.; Qing, R.; Harvey, D.; Li, Y.; Larson, T.R.; Graham, I.A.
Identification of a long-chain polyunsaturated fatty acid acyl-coenzyme A synthetase from the diatom Thalassiosira pseudonana
Plant Physiol.
138
402-408
2005
Thalassiosira pseudonana
Parkes, H.A.; Preston, E.; Wilks, D.; Ballesteros, M.; Carpenter, L.; Wood, L.; Kraegen, E.W.; Furler, S.M.; Cooney, G.J.
Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo
Am. J. Physiol. Endocrinol. Metab.
291
E737-E744
2006
Rattus norvegicus (P18163), Homo sapiens (P33121), Homo sapiens, Mus musculus (P41216), Mus musculus
Durgan, D.J.; Smith, J.K.; Hotze, M.A.; Egbejimi, O.; Cuthbert, K.D.; Zaha, V.G.; Dyck, J.R.; Abel, E.D.; Young, M.E.
Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin
Am. J. Physiol. Heart Circ. Physiol.
290
H2480-H2497
2006
Mus musculus, Rattus norvegicus
Mercade, A.; Estelle, J.; Perez-Enciso, M.; Varona, L.; Silio, L.; Noguera, J.L.; Sanchez, A.; Folch, J.M.
Characterization of the porcine acyl-CoA synthetase long-chain 4 gene and its association with growth and meat quality traits
Anim. Genet.
37
219-224
2006
Sus scrofa
Fraisl, P.; Tanaka, H.; Forss-Petter, S.; Lassmann, H.; Nishimune, Y.; Berger, J.
A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis
Arch. Biochem. Biophys.
451
23-33
2006
Homo sapiens (Q5FVE4), Homo sapiens, Mus musculus
Golovko, M.Y.; Rosenberger, T.A.; Faergeman, N.J.; Feddersen, S.; Cole, N.B.; Pribill, I.; Berger, J.; Nussbaum, R.L.; Murphy, E.J.
Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism
Biochemistry
45
6956-6966
2006
Mus musculus
Stinnett, L.; Lewin, T.M.; Coleman, R.A.
Mutagenesis of rat acyl-CoA synthetase 4 indicates amino acids that contribute to fatty acid binding
Biochim. Biophys. Acta
1771
119-125
2007
Rattus norvegicus (O35547)
Li, H.; Melton, E.M.; Quackenbush, S.; DiRusso, C.C.; Black, P.N.
Mechanistic studies of the long chain acyl-CoA synthetase Faa1p from Saccharomyces cerevisiae
Biochim. Biophys. Acta
1771
1246-1253
2007
Saccharomyces cerevisiae
Black, P.N.; DiRusso, C.C.
Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation
Biochim. Biophys. Acta
1771
286-298
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P38137), Saccharomyces cerevisiae (P38225), Saccharomyces cerevisiae (P39518), Rattus norvegicus (O35547), Rattus norvegicus (O88813)
De Jong, H.; Neal, A.C.; Coleman, R.A.; Lewin, T.M.
Ontogeny of mRNA expression and activity of long-chain acyl-CoA synthetase (ACSL) isoforms in Mus musculus heart
Biochim. Biophys. Acta
1771
75-82
2007
Mus musculus (P41216), Mus musculus (Q8JZR0), Mus musculus (Q91WC3), Mus musculus (Q9CZW4), Mus musculus (Q9QUJ7), Mus musculus
Fujimoto, Y.; Onoduka, J.; Homma, K.J.; Yamaguchi, S.; Mori, M.; Higashi, Y.; Makita, M.; Kinoshita, T.; Noda, J.; Itabe, H.; Takanoa, T.
Long-chain fatty acids induce lipid droplet formation in a cultured human hepatocyte in a manner dependent of acyl-CoA synthetase
Biol. Pharm. Bull.
29
2174-2180
2006
Homo sapiens
Oba, Y.; Tanaka, K.; Inouye, S.
Catalytic properties of domain-exchanged chimeric proteins between firefly luciferase and Drosophila fatty acyl-CoA synthetase CG6178
Biosci. Biotechnol. Biochem.
70
2739-2744
2006
Drosophila melanogaster (Q9VCC6), Drosophila melanogaster
Soupene, E.; Kuypers, F.A.
Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains
BMC Mol. Biol.
7
21
2006
Homo sapiens, Homo sapiens (Q9UKU0)
Sung, Y.K.; Park, M.K.; Hong, S.H.; Hwang, S.Y.; Kwack, M.H.; Kim, J.C.; Kim, M.K.
Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells
Exp. Mol. Med.
39
477-482
2007
Homo sapiens (O60488), Homo sapiens
Li, L.O.; Mashek, D.G.; An, J.; Doughman, S.D.; Newgard, C.B.; Coleman, R.A.
Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes
J. Biol. Chem.
281
37246-37255
2006
Rattus norvegicus (P18163)
Jia, Z.; Moulson, C.L.; Pei, Z.; Miner, J.H.; Watkins, P.A.
Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts
J. Biol. Chem.
282
20573-20583
2007
Mus musculus (O88561), Mus musculus
Yao, H.; Ye, J.
Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells
J. Biol. Chem.
283
849-854
2007
Homo sapiens (O60488), Homo sapiens (O95573), Homo sapiens (P33121), Homo sapiens
Milger, K.; Herrmann, T.; Becker, C.; Gotthardt, D.; Zickwolf, J.; Ehehalt, R.; Watkins, P.A.; Stremmel, W.; Fuellekrug, J.
Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4
J. Cell Sci.
119
4678-4688
2006
Homo sapiens (Q6P1M0), Mus musculus (Q91VE0)
Mashek, D.G.; Li, L.O.; Coleman, R.A.
Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet
J. Lipid Res.
47
2004-2010
2006
Rattus norvegicus (O35547), Rattus norvegicus (O88813), Rattus norvegicus (P18163), Rattus norvegicus (P33124), Rattus norvegicus (Q63151)
Song, S.Y.; Kato, C.; Adachi, E.; Moriya-Sato, A.; Inagawa-Ogashiwa, M.; Umeda, R.; Hashimoto, N.
Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination
J. Neurosci. Res.
85
3586-3597
2007
Rattus norvegicus
Li, J.; Sheng, Y.; Tang, P.Z.; Tsai-Morris, C.H.; Dufau, M.L.
Tissue-cell- and species-specific expression of gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) in gonads, adrenal and brain. Identification of novel forms in the brain
J. Steroid Biochem. Mol. Biol.
98
207-217
2006
Rattus norvegicus (Q63151), Mus musculus (Q99PU5), Mus musculus
Cano, F.; Poderoso, C.; Cornejo Maciel, F.; Castilla, R.; Maloberti, P.; Castillo, F.; Neuman, I.; Paz, C.; Podesta, E.J.
Protein tyrosine phosphatases regulate arachidonic acid release, StAR induction and steroidogenesis acting on a hormone-dependent arachidonic acid-preferring acyl-CoA synthetase
J. Steroid Biochem. Mol. Biol.
99
197-202
2006
Mus musculus (Q61193)
Norimine, J.; Ruef, B.J.; Palmer, G.H.; Knowles, D.P.; Herndon, D.R.; Rice-Ficht, A.C.; Brown, W.C.
A novel 78-kDa fatty acyl-CoA synthetase (ACS1) of Babesia bovis stimulates memory CD4+ T lymphocyte responses in B. bovis-immune cattle
Mol. Biochem. Parasitol.
147
20-29
2006
Babesia bovis (Q6QLU3), Babesia bovis
Bethke, L.L.; Zilversmit, M.; Nielsen, K.; Daily, J.; Volkman, S.K.; Ndiaye, D.; Lozovsky, E.R.; Hartl, D.L.; Wirth, D.F.
Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum
Mol. Biochem. Parasitol.
150
10-24
2006
Plasmodium falciparum
Lu, X.; Zhang, H.; Tonge, P.J.; Tan, D.S.
Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis
Bioorg. Med. Chem. Lett.
18
5963-5966
2008
Mycobacterium tuberculosis
Matsuda, D.; Namatame, I.; Ohshiro, T.; Ishibashi, S.; Omura, S.; Tomoda, H.
Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor
J. Antibiot.
61
318-321
2008
Mus musculus
Abe, T.; Hashimoto, Y.; Hosaka, H.; Tomita-Yokotani, K.; Kobayashi, M.
Discovery of amide (peptide) bond synthetic activity in acyl-CoA synthetase
J. Biol. Chem.
283
11312-11321
2008
Pseudomonas chlororaphis (Q5CD72), Pseudomonas chlororaphis B23 (Q5CD72)
Kienow, L.; Schneider, K.; Bartsch, M.; Stuible, H.P.; Weng, H.; Miersch, O.; Wasternack, C.; Kombrink, E.
Jasmonates meet fatty acids: functional analysis of a new acyl-coenzyme A synthetase family from Arabidopsis thaliana
J. Exp. Bot.
59
403-419
2008
Arabidopsis thaliana
Day, J.C.; Goodall, T.I.; Bailey, M.J.
The evolution of the adenylate-forming protein family in beetles: Multiple luciferase gene paralogues in fireflies and glow-worms
Mol. Phylogenet. Evol.
50
93-101
2008
Tribolium castaneum, Photinus pyralis (P08659)
Inouye, S.
Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions
Cell. Mol. Life Sci.
67
387-404
2010
Agrypnus binodulus, Drosophila melanogaster (Q9VCC6)
Reiser, K.; Davis, M.A.; Hynes, M.J.
Aspergillus nidulans contains six possible fatty acyl-CoA synthetases with FaaB being the major synthetase for fatty acid degradation
Arch. Microbiol.
192
373-382
2010
Aspergillus nidulans
Zalatan, F.; Black, P.
Characterization of long-chain fatty acid uptake in Caulobacter crescentus
Arch. Microbiol.
193
479-487
2011
Caulobacter vibrioides
Reinartz, A.; Ehling, J.; Leue, A.; Liedtke, C.; Schneider, U.; Kopitz, J.; Weiss, T.; Hellerbrand, C.; Weiskirchen, R.; Knuechel, R.; Gassler, N.
Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis
Biochim. Biophys. Acta
1801
1025-1035
2010
Homo sapiens
Soupene, E.; Dinh, N.P.; Siliakus, M.; Kuypers, F.A.
Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains
BMC Biochem.
11
18
2010
Homo sapiens
Mullaney, B.C.; Blind, R.D.; Lemieux, G.A.; Perez, C.L.; Elle, I.C.; Faergeman, N.J.; Van Gilst, M.R.; Ingraham, H.A.; Ashrafi, K.
Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25
Cell Metab.
12
398-410
2010
Caenorhabditis elegans
Ellis, J.M.; Li, L.O.; Wu, P.C.; Koves, T.R.; Ilkayeva, O.; Stevens, R.D.; Watkins, S.M.; Muoio, D.M.; Coleman, R.A.
Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis
Cell Metab.
12
53-64
2010
Mus musculus
Zhang, Y.; Zhang, Y.; Gao, Y.; Zhao, X.; Wang, Z.
Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation
Dev. Biol.
353
259-265
2011
Drosophila melanogaster
Chang, Y.S.; Tsai, C.T.; Huangfu, C.A.; Huang, W.Y.; Lei, H.Y.; Lin, C.F.; Su, I.J.; Chang, W.T.; Wu, P.H.; Chen, Y.T.; Hung, J.H.; Young, K.C.; Lai, M.D.
ACSL3 and GSK-3beta are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells
J. Cell. Biochem.
112
881-893
2011
Homo sapiens
Bu, S.Y.; Mashek, D.G.
Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways
J. Lipid Res.
51
3270-3280
2010
Rattus norvegicus (O88813)
Golej, D.L.; Askari, B.; Kramer, F.; Barnhart, S.; Vivekanandan-Giri, A.; Pennathur, S.; Bornfeldt, K.E.
Long-chain acyl-CoA synthetase 4 modulates prostaglandin E2 release from human arterial smooth muscle cells
J. Lipid Res.
52
782-793
2011
Homo sapiens
Zhao, L.; Katavic, V.; Li, F.; Haughn, G.W.; Kunst, L.
Insertional mutant analysis reveals that long-chain acyl-CoA synthetase 1 (LACS1), but not LACS8, functionally overlaps with LACS9 in Arabidopsis seed oil biosynthesis
Plant J.
64
1048-1058
2010
Arabidopsis thaliana
Kang, Y.; Zarzycki-Siek, J.; Walton, C.B.; Norris, M.H.; Hoang, T.T.
Multiple FadD acyl-CoA synthetases contribute to differential fatty acid degradation and virulence in Pseudomonas aeruginosa
PLoS ONE
5
e13557
2010
Pseudomonas aeruginosa (Q9HYU3), Pseudomonas aeruginosa (Q9HYU4), Pseudomonas aeruginosa
Qiao, S.; Tuohimaa, P.
Expression and vitamin D3 regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells
Prostaglandins Leukot. Essent. Fatty Acids
84
19-23
2011
Homo sapiens
Smith, M.E.; Saraceno, G.E.; Capani, F.; Castilla, R.
Long-chain acyl-CoA synthetase 4 is regulated by phosphorylation
Biochem. Biophys. Res. Commun.
430
272-277
2013
Mus musculus
Melton, E.M.; Cerny, R.L.; DiRusso, C.C.; Black, P.N.
Overexpression of human fatty acid transport protein 2/very long chain acyl-CoA synthetase 1 (FATP2/Acsvl1) reveals distinct patterns of trafficking of exogenous fatty acids
Biochem. Biophys. Res. Commun.
440
743-748
2013
Homo sapiens
Kuwata, H.; Yoshimura, M.; Sasaki, Y.; Yoda, E.; Nakatani, Y.; Kudo, I.; Hara, S.
Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1beta-stimulated rat fibroblasts
Biochim. Biophys. Acta
1841
44-53
2014
Rattus norvegicus
Dong, Y.; Du, H.; Gao, C.; Ma, T.; Feng, L.
Characterization of two long-chain fatty acid CoA ligases in the Gram-positive bacterium Geobacillus thermodenitrificans NG80-2
Microbiol. Res.
167
602-607
2012
Geobacillus thermodenitrificans, Geobacillus thermodenitrificans NG80-2
Pulsifer, I.P.; Kluge, S.; Rowland, O.
Arabidopsis long-chain acyl-CoA synthetase 1 (LACS1), LACS2, and LACS3 facilitate fatty acid uptake in yeast
Plant Physiol. Biochem.
51
31-39
2012
Arabidopsis thaliana
Nchoutmboube, J.A.; Viktorova, E.G.; Scott, A.J.; Ford, L.A.; Pei, Z.; Watkins, P.A.; Ernst, R.K.; Belov, G.A.
Increased long chain acyl-CoA synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organelles
PLoS Pathog.
9
e1003401
2013
Homo sapiens
De Marcos Lousa, C.; van Roermund, C.W.; Postis, V.L.; Dietrich, D.; Kerr, I.D.; Wanders, R.J.; Baldwin, S.A.; Baker, A.; Theodoulou, F.L.
Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids
Proc. Natl. Acad. Sci. USA
110
1279-1284
2013
Arabidopsis thaliana
Klaus, C.; Jeon, M.K.; Kaemmerer, E.; Gassler, N.
Intestinal acyl-CoA synthetase 5: activation of long chain fatty acids and behind
World J. Gastroenterol.
19
7369-7373
2013
Homo sapiens
Rosen, B.C.; Dillon, N.A.; Peterson, N.D.; Minato, Y.; Baughn, A.D.
Long-chain fatty acyl coenzyme A ligase FadD2 mediates intrinsic pyrazinamide resistance in Mycobacterium tuberculosis
Antimicrob. Agents Chemother.
61
e02130-16
2017
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Hinder, L.; Figueroa-Romero, C.; Pacut, C.; Hong, Y.; Vivekanandan-Giri, A.; Pennathur, S.; Feldman, E.
Long-chain acyl coenzyme a synthetase 1 overexpression in primary cultured Schwann cells prevents long chain fatty acid-induced oxidative stress and mitochondrial dysfunction
Antioxid. Redox Signal.
21
588-600
2014
Rattus norvegicus (P18163)
Tuohetahuntila, M.; Spee, B.; Kruitwagen, H.S.; Wubbolts, R.; Brouwers, J.F.; van de Lest, C.H.; Molenaar, M.R.; Houweling, M.; Helms, J.B.; Vaandrager, A.B.
Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells
Biochim. Biophys. Acta
1851
220-230
2015
Rattus norvegicus (O35547)
Zheng, M.; Huang, Y.; Zheng, L.; Sun, Z.; Wang, L.
Cloning, expression and stress-respondent transcription of long-chain acyl-coenzyme A synthetase cDNA gene of Nannochloropsis gaditana and its involvement in the biosynthesis of eicosapentaenoic and decosahexaenoic acids
Biotechnol. Lett.
36
141-145
2014
Nannochloropsis gaditana (S5PTC7), Nannochloropsis gaditana HH-1 (S5PTC7)
-
Liu, Z.; Huang, Y.; Hu, W.; Huang, S.; Wang, Q.; Han, J.; Zhang, Y.Q.
dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling
J. Neurosci.
34
2785-2796
2014
Drosophila melanogaster, Homo sapiens (O60488), Homo sapiens
Teodoro, B.G.; Sampaio, I.H.; Bomfim, L.H.; Queiroz, A.L.; Silveira, L.R.; Souza, A.O.; Fernandes, A.M.; Eberlin, M.N.; Huang, T.Y.; Zheng, D.; Neufer, P.D.; Cortright, R.N.; Alberici, L.C.
Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle
J. Physiol.
595
677-693
2017
Rattus norvegicus, Homo sapiens (Q9UKU0), Homo sapiens
Jessen, D.; Roth, C.; Wiermer, M.; Fulda, M.
Two activities of long-chain acyl-coenzyme A synthetase are involved in lipid trafficking between the endoplasmic reticulum and the plastid in Arabidopsis
Plant Physiol.
167
351-366
2015
Arabidopsis thaliana
Yu, L.; Tan, X.; Jiang, B.; Sun, X.; Gu, S.; Han, T.; Hou, W.
A peroxisomal long-chain acyl-CoA synthetase from Glycine max involved in lipid degradation
PLoS ONE
9
e100144
2014
Glycine max
Yan, S.; Yang, X.F.; Liu, H.L.; Fu, N.; Ouyang, Y.; Qing, K.
Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases an update
World J. Gastroenterol.
21
3492-3498
2015
Mus musculus (P41216), Mus musculus (Q8JZR0), Mus musculus (Q91WC3), Mus musculus (Q9CZW4), Mus musculus (Q9QUJ7)
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