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Literature summary for 6.2.1.3 extracted from

  • Mashek, D.G.; McKenzie, M.A.; Van Horn, C.G.; Coleman, R.A.
    Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglcyerol in McArdle-RH7777 cells (2005), J. Biol. Chem., 281, 945-950.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triacsin C ACSL activity is 17fold higher in the presence of 0.02 mM triacsin C Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
ectopical overexpression of ACSL5 in rat hepatoma McArdle-RH7777 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum Ad-ACSL-5, long chain acyl-CoA synthetase 5 overexpressed in rat hepatoma McRrdle-RG7777 cells mediated by adenovirus colocalizes to both mitochondria and endoplasmic reticulum Rattus norvegicus 5783
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mitochondrion
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Rattus norvegicus 5739
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mitochondrion ACSl5 is the only isoform of long chain acyl-CoA synthetase partly located on mitochondria. Ad-ACSL-5, long chain acyl-CoA synthetase 5 overexpressed in rat hepatoma McRrdle-RG7777 cells mediated by adenovirus colocalizes to both mitochondria and endoplasmic reticulum Rattus norvegicus 5739
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Rattus norvegicus O88813
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-

Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell
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Rattus norvegicus
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McA-RH7777 cell
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + oleate + CoA
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Rattus norvegicus AMP + diphosphate + oleoyl-CoA
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?

Synonyms

Synonyms Comment Organism
ACSL5
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Rattus norvegicus
long chain acyl-CoA synthetase 5
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Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
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Rattus norvegicus