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Literature summary for 6.2.1.3 extracted from
- Kinetic studies on the specificity of long chain acyl coenzyme A synthetase from rat liver microsomes (1972), J. Biol. Chem., 247, 4433-4436.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | competitive inhibitor of palmitoleic acid activation | Rattus norvegicus |  |
| Eicosa-11,14,17-trienoic acid | competitive inhibitor of palmitoleic acid activation | Rattus norvegicus | |
| eicosa-8,11,14-trienoic acid | competitive inhibitor of palmitoleic acid activation | Rattus norvegicus | |
| Eicosa-8,14-dienoic acid | competitive inhibitor of palmitoleic acid activation | Rattus norvegicus | |
| palmitate | linolenic acid activation | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00139 | - |
oleate | - |
Rattus norvegicus | |
| 0.00164 | - |
linolenate | - |
Rattus norvegicus | |
| 0.00204 | - |
palmitoleate | - |
Rattus norvegicus | |
| 0.00222 | - |
linoleate | - |
Rattus norvegicus | |
| 0.00278 | - |
palmitate | - |
Rattus norvegicus | |
| 0.0072 | - |
CoA | activation of palmitic acid | Rattus norvegicus | |
| 0.0094 | - |
CoA | activation of oleic acid | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + linoleate + CoA | - |
Rattus norvegicus | AMP + diphosphate + linoleoyl-CoA | - |
? | |
| ATP + linolenate + CoA | - |
Rattus norvegicus | AMP + diphosphate + linolenoyl-CoA | - |
? | |
| ATP + oleate + CoA | - |
Rattus norvegicus | AMP + diphosphate + oleoyl-CoA | - |
? | |
| ATP + palmitate + CoA | - |
Rattus norvegicus | AMP + diphosphate + palmitoyl-CoA | - |
? | |
| ATP + palmitoleate + CoA | - |
Rattus norvegicus | AMP + diphosphate + palmitoleoyl-CoA | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
half-life: 15 min | Rattus norvegicus |
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Release 2023.1 (January 2023)
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