Information on EC 6.2.1.3 - long-chain-fatty-acid-CoA ligase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
6.2.1.3
-
RECOMMENDED NAME
GeneOntology No.
long-chain-fatty-acid-CoA ligase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Acid-thiol ligation
-
-
-
-
Phosphorylation
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
(Z)-9-tricosene biosynthesis
-
6-gingerol analog biosynthesis
-
alkane biosynthesis II
-
arachidonate biosynthesis
-
docosahexanoate biosynthesis I
-
docosahexanoate biosynthesis II
-
eicosapentaenoate biosynthesis II (metazoa)
-
fatty acid activation
-
fatty acid alpha-oxidation II
-
fatty acid alpha-oxidation III
-
fatty acid beta-oxidation (peroxisome, yeast)
-
fatty acid beta-oxidation I
-
fatty acid beta-oxidation II (peroxisome)
-
fatty acid beta-oxidation VI (peroxisome)
-
Fatty acid degradation
-
fatty acid salvage
-
gamma-linolenate biosynthesis II (animals)
-
linoleate biosynthesis I (plants)
-
linoleate biosynthesis II (animals)
-
long chain fatty acid ester synthesis for microdiesel production
-
Metabolic pathways
-
octane oxidation
-
phosphatidylcholine acyl editing
-
phytol degradation
-
stearate biosynthesis I (animals)
-
wax esters biosynthesis II
-
SYSTEMATIC NAME
IUBMB Comments
long-chain fatty acid:CoA ligase (AMP-forming)
Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
ACS
P18163
-
ACS
-, P38137, P38225, P39518
-
ACS1
Q6QLU3
-
ACS3
-
-
-
-
ACS3
Q63151
-
ACS4
Q61193
-
ACS6
Q9FNT6
-
AcsA
Pseudomonas chlororaphis B23
Q5CD72
-
-
ACSL
-
-
ACSL1
-
-
ACSL1
P33121
-
ACSL1
P41216
-
ACSL3
O95573
specifically required for incorporation of fatty acids into phosphatidylcholine
ACSL3
Q9CZW4
-
ACSL3
Q63151
-
ACSL4
O60488
-
ACSL4
Q9QUJ7
-
ACSL4
O35547
prefers longer chain polyunsaturated fatty acids as substrates
ACSL4
-
-
ACSL5
Q8JZR0
-
ACSL6
-
-
ACSL6
Q91WC3
-
ACSL6
P33124
-
ACSL6 protein
Q9UKU0
-
ACSL6_v1
-
-
ACSL6_v1
-
-
ACSL6_v2
Q9UKU0
-
ACSL6_v2
-
-
ACSL6_v3
Q9UKU0
-
ACSL6_v5
-
-
ACSL6_v6
-
-
Acyl coenzyme A synthetase
-
-
-
-
Acyl-activating enzyme
-
-
-
-
Acyl-CoA ligase
-
-
-
-
acyl-CoA synthase-3
-
-
Acyl-CoA synthetase
-
-
-
-
Acyl-CoA synthetase
-
-
Acyl-CoA synthetase
Q6P1M0
-
Acyl-CoA synthetase
-
-
Acyl-CoA synthetase
Q91VE0
-
Acyl-CoA synthetase
-
-
Acyl-CoA synthetase
-
-
Acyl-CoA synthetase
Q9HYU3, Q9HYU4
-
Acyl-CoA synthetase
Q5CD72
-
Acyl-CoA synthetase
Pseudomonas chlororaphis B23
Q5CD72
-
-
Acyl-CoA synthetase
-
-
Acyl-CoA synthetase
-, P38137, P38225, P39518
-
Acyl-CoA synthetase 3
-
-
-
-
acyl-CoA synthetase 4
Q61193
-
acyl-CoA synthetase 4
O35547
-
acyl-CoA synthetase 5
-
-
acyl-CoA synthetase 5
O88813
-
acyl-CoA synthetase-1
P33121
-
acyl-CoA synthetase-1
-
-
acyl-CoA synthetase-1
P41216
-
acyl-CoA synthetase-1
P18163
-
Acyl-coenzyme A ligase
-
-
-
-
bubblegum-related protein
-
-
FAA1
-
-
-
-
Faa1p
-
in the peroxisome
Faa2p
-, P39518
-
Faa3p
-
in the membrane
Faa4p
-
in membrane and cytosol
FACL3
-
-
FACL3/ACS3
-
-
FACL4
O60488
-
FACS
Q924N5
-
FACS
Q63151
-
FAdD
Q9HYU3, Q9HYU4
gene name
FAdD
-, Q63151
-
FATP4
Q6P1M0
-
FATP4
-
bifunctional enzyme, exhibiting both fatty acid transport and acyl-CoA synthetase activities
FATP4
O88561
-
FATP4
Q91VE0
-
Fatty acid CoA ligase
-
-
-
-
fatty acid CoA ligase: AMP forming
-
-
fatty acid thiokinase
-, P38137, P38225, P39518
-
Fatty acid thiokinase (long chain)
-
-
-
-
fatty acid transport protein
-
bifunctional enzyme, exhibiting both fatty acid transport and acyl-CoA synthetase activities
fatty acid transport protein 4
O88561
-
fatty acid-CoA ligase 4
O60488
-
fatty acid:CoA ligase, AMP-forming
-, P38137, P38225, P39518
-
fatty acyl-CoA synthetase
-
-
fatty acyl-CoA synthetase
Q6QLU3
-
fatty acyl-CoA synthetase
Q9VCC6
-
fatty acyl-CoA synthetase
-
-
fatty acyl-CoA synthetase
-
-
fatty acyl-CoA synthetase
P08659
-
fatty acyl-CoA synthetase
-
-
fatty acyl-CoA synthetase
-
-
fatty acyl-CoA synthetase
Trypanosoma brucei 427
-
-
-
Fatty acyl-coenzyme A synthetase
-
-
-
-
Fatty-acyl-CoA ligase
-
-
-
-
gonadotropin-regulated long chain acyl-CoA synthetase
-
-
gonadotropin-regulated long-chain acyl CoA synthetase
-
-
GR-LACS
-
-
LACS
-
-
-
-
LACS
-
-
LACS
Q924N5
-
LACS
Q63151
-
LCFA synthetase
-
-
-
-
lipidosin
-
-
lipidosin
-
-
long chain acyl-CoA synthetase
-
-
long chain acyl-CoA synthetase
O88561
-
long chain acyl-CoA synthetase
Q924N5
-
long chain acyl-CoA synthetase
O35547, O88813, P18163, P33124
-
long chain acyl-CoA synthetase
Q63151
-
long chain acyl-CoA synthetase
-
-
long chain acyl-CoA synthetase 1
-
-
long chain acyl-CoA synthetase 1
P18163
-
long chain acyl-CoA synthetase 2
-
-
long chain acyl-CoA synthetase 3
O95573
-
long chain acyl-CoA synthetase 3
Q63151
-
long chain acyl-CoA synthetase 4
-
-
long chain acyl-CoA synthetase 4
O35547
-
long chain acyl-CoA synthetase 5
-
-
long chain acyl-CoA synthetase 5
O88813
-
Long chain fatty acyl CoA ligase
-
-
-
-
Long chain fatty acyl-CoA synthetase
-
-
-
-
long chain fatty acyl-CoA synthetase 5
-
-
long fatty acyl-CoA synthetase
Q9VCC6
-
Long-chain acyl CoA synthetase
-
-
-
-
Long-chain acyl CoA synthetase
-
-
long-chain acyl coenzyme A synthetase 1
-
-
long-chain acyl-CoA synthetase
-
-
long-chain acyl-CoA synthetase
-
-
long-chain acyl-CoA synthetase
-
-
long-chain acyl-CoA synthetase
P41216, Q8JZR0, Q91WC3, Q9CZW4, Q9QUJ7
-
long-chain acyl-CoA synthetase
-
-
long-chain acyl-CoA synthetase
-
-
long-chain acyl-CoA synthetase 1
-
-
long-chain acyl-CoA synthetase 5
O88813
-
long-chain acyl-CoA synthetase 6
-
-
Long-chain acyl-CoA synthetase I
-
-
-
-
Long-chain acyl-CoA synthetase II
-
-
-
-
long-chain acyl-CoA synthetase-1
-
-
long-chain acyl-CoA synthetases
-, Q9UKU0
-
Long-chain acyl-coenzyme A synthetase
-
-
-
-
long-chain fatty acid:CoA ligase
-
-
Long-chain fatty acyl coenzyme A synthetase
-
-
-
-
long-chain fatty acyl-CoA synthetase
-
-
long-chain fatty-acid-CoA ligase 3
-
-
long-chain polyunsaturated fatty acid acyl-coenzyme A synthetase
-
-
luciferase-like gene
-
-
luciferase-like protein
P08659
-
luciferase-like protein
-
-
mACS4
-
-
-
-
MALCE1
C8KHM6
-
MALCE1
Mortierella alpina 1S-4
C8KHM6
-
-
Oleoyl-CoA synthetase
-
-
-
-
OPC-8:CoA ligase
-
-
Palmitoyl coenzyme A synthetase
-
-
-
-
Palmitoyl-CoA ligase
-
-
-
-
Palmityl-coenzyme A synthetase
-
-
-
-
PhpLL1
P08659
-
Pristanoyl-CoA synthetase
-
-
-
-
protein At1g20510
-
-
putative long-chain acyl-CoA synthetase
Q6QLU3
-
R-ibuprofenoyl-CoA synthetase
-
-
Stearoyl-CoA synthetase
-
-
-
-
TbACS3
Trypanosoma brucei 427
-
-
-
Thiokinase
-
-
-
-
YBR041W
P38225
-
YBR222C
P38137
-
YER015W
P39518
-
additional information
-
the enzyme belongs to a fatty acyl-CoA synthetase family, which is distinct from the known long-chain fatty acyl-CoA synthetase, LACS, and the 4-coumarate:CoA ligase, 4CL, families, overview
additional information
-
the ezyme is a member of the ACSL gene family that catalyzes the activation of long-chain fatty acids for lipid biosynthesis
additional information
P08659
the enzyme is a part of a larger AMP-forming superfamily
additional information
Q5CD72
acyl-CoA synthetase belongs to the superfamily of adenylate-forming enzymes, whose three-dimensional structures are analogous to one another
additional information
Pseudomonas chlororaphis B23
Q5CD72
acyl-CoA synthetase belongs to the superfamily of adenylate-forming enzymes, whose three-dimensional structures are analogous to one another
-
additional information
-
the enzyme is a part of a larger AMP-forming superfamily
CAS REGISTRY NUMBER
COMMENTARY
9013-18-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Col-0, Ws-0, gene OPCL1
-
-
Manually annotated by BRENDA team
isoenzyme LACS2
-
-
Manually annotated by BRENDA team
isozymes LACS1-LACS9
-
-
Manually annotated by BRENDA team
isozyme ACS-3, gene acs-3
-
-
Manually annotated by BRENDA team
isozyme dAcsl
-
-
Manually annotated by BRENDA team
gene faaB or AN8280.3 encoding isozyme FaaB
-
-
Manually annotated by BRENDA team
multiple charge isoforms: 4.6, 5.0 and 5.6
-
-
Manually annotated by BRENDA team
wild-type and mutant forms
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
heat inactivation does not distinguish between arachidonoyl-CoA synthetase, EC 6.2.1.15, and palmitoyl-CoA synthetase
-
-
Manually annotated by BRENDA team
isozyme ACSL5
-
-
Manually annotated by BRENDA team
isozyme ACSL6
-
-
Manually annotated by BRENDA team
isozymes ACSL1, ACSL3, and ACSL5
-
-
Manually annotated by BRENDA team
palmitoyl-CoA synthetase and arachidonoyl-CoA synthetase, EC 6.2.1.5, are not separate enzymes
-
-
Manually annotated by BRENDA team
strain 1S-4
UniProt
Manually annotated by BRENDA team
Mortierella alpina 1S-4
strain 1S-4
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
North American firefly
UniProt
Manually annotated by BRENDA team
FadD1; gene FadD1
UniProt
Manually annotated by BRENDA team
FadD2; gene FadD2
UniProt
Manually annotated by BRENDA team
strain B23, gene acsA
UniProt
Manually annotated by BRENDA team
Pseudomonas chlororaphis B23
strain B23, gene acsA
UniProt
Manually annotated by BRENDA team
ACS3, one of multiple form of the enzyme in brain
SwissProt
Manually annotated by BRENDA team
isoenzyme ACS1; isoenzyme ACS2
UniProt
Manually annotated by BRENDA team
isoenzyme ACSL3; isoenzyme ACSL6_v1; isoenzyme ACSL6_v2
UniProt
Manually annotated by BRENDA team
isozyme ACSL5
UniProt
Manually annotated by BRENDA team
long chain acyl-CoA synthetase 1; long chain acyl-CoA synthetase 2; long chain acyl-CoA synthetase 4; long chain acyl-CoA synthetase 5
-
-
Manually annotated by BRENDA team
long chain acyl-CoA synthetase 3
SwissProt
Manually annotated by BRENDA team
Iberian Guadyerbas x Landrace cross breed
-
-
Manually annotated by BRENDA team
strain HB8
-
-
Manually annotated by BRENDA team
red flour beetle
-
-
Manually annotated by BRENDA team
strain 427
-
-
Manually annotated by BRENDA team
Trypanosoma brucei 427
strain 427
-
-
Manually annotated by BRENDA team
Ulmus sp.
elm
-
-
Manually annotated by BRENDA team
2 enzyme forms: long-chain acyl-CoA synthetase I and long-chain acyl-CoA synthetase II
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.003
-
ATP
-
pH 7.5, 37C, mutant enzyme T214A
0.008
-
ATP
-
pH 7.5, 37C, mutant enzyme G216A; pH 7.5, 37C, mutant enzyme K222A; pH 7.5, 37C, mutant enzyme T217A
0.017
-
ATP
-
pH 7.5, 37C, mutant enzyme G219A
0.029
-
ATP
-
pH 7.5, 37C, wild-type enzyme
0.278
-
lauric acid
-
-
0.651
-
lauric acid
-
-
0.5
-
tetradecanoate
-
enzyme TbACS1
1.1
-
tetradecanoate
-
enzyme TbACS3
1.2
-
tetradecanoate
-
enzyme TbACS4
PDB
SCOP
CATH
ORGANISM
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
enzyme does not contain carbohydrate, phospholipid and fatty acid