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Literature summary for 6.2.1.3 extracted from

  • Philipp, D.P.; Parsons, P.
    Kinetic characterization of long chain fatty acyl coenzyme A ligase from rat liver mitochondria (1979), J. Biol. Chem., 254, 10785-10790.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
AMP
-
Rattus norvegicus
ATP above 15 mM Rattus norvegicus
Brij 58 maximal inhibition at 4% detergent Rattus norvegicus
diphosphate
-
Rattus norvegicus
sodium cholate maximal inhibition at 1% detergent Rattus norvegicus
Triton X-100 maximal inhibition at 4% detergent Rattus norvegicus
Tween 80 maximal inhibition at 4% detergent Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
ATP CoA Rattus norvegicus
4.1
-
ATP at 20 mM MgCl2 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus
Mg2+ maximal activity at 15-20 mM MgCl2, no inhibition at higher concentrations Rattus norvegicus
Mn2+ divalent cation required, Mn2+ can replace Mg2+ in activation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA mitochondrial long chain fatty acyl-CoA ligase, unlike short chain ligases and medium chain ligases, does not utilize an adenylate as an intermediate in the formation of fatty acyl-CoA Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + palmitate + CoA
-
Rattus norvegicus AMP + diphosphate + palmitoyl-CoA
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8.3
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6 9.8 pH 6: about 50% of maximal activity, pH 8.9: about 60% of maximal activity Rattus norvegicus