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Literature summary for 6.2.1.3 extracted from

  • Ellis, J.M.; Li, L.O.; Wu, P.C.; Koves, T.R.; Ilkayeva, O.; Stevens, R.D.; Watkins, S.M.; Muoio, D.M.; Coleman, R.A.
    Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis (2010), Cell Metab., 12, 53-64.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information specific knockout of ACSL1 in mice leads to 30% increased fat mass when fed a low-fat diet, and normal fat mass with high-fat diet. The mutants incorporate oleate into fatty acids normally, but show 50-90% reduced fatty acid oxidation rates compared to the wild-type. The mutant mice are cold-intolerant and insensitive to beta3-adrenergic agonist activation, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + hexadecanoate + CoA Mus musculus
-
AMP + diphosphate + hexadecanoyl-CoA
-
?
ATP + octadecanoate + CoA Mus musculus
-
AMP + diphosphate + octadecanoyl-CoA
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
Mus musculus
-
brown adipose tissue
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + hexadecanoate + CoA
-
Mus musculus AMP + diphosphate + hexadecanoyl-CoA
-
?
ATP + octadecanoate + CoA
-
Mus musculus AMP + diphosphate + octadecanoyl-CoA
-
?

Synonyms

Synonyms Comment Organism
ACSL1
-
Mus musculus
acyl-CoA synthetase-1
-
Mus musculus
long-chain acyl-CoA synthetase-1
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus