Protein Variants | Comment | Organism |
---|---|---|
additional information | specific knockout of ACSL1 in mice leads to 30% increased fat mass when fed a low-fat diet, and normal fat mass with high-fat diet. The mutants incorporate oleate into fatty acids normally, but show 50-90% reduced fatty acid oxidation rates compared to the wild-type. The mutant mice are cold-intolerant and insensitive to beta3-adrenergic agonist activation, phenotype, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + hexadecanoate + CoA | Mus musculus | - |
AMP + diphosphate + hexadecanoyl-CoA | - |
? | |
ATP + octadecanoate + CoA | Mus musculus | - |
AMP + diphosphate + octadecanoyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Mus musculus | - |
brown adipose tissue | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + hexadecanoate + CoA | - |
Mus musculus | AMP + diphosphate + hexadecanoyl-CoA | - |
? | |
ATP + octadecanoate + CoA | - |
Mus musculus | AMP + diphosphate + octadecanoyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACSL1 | - |
Mus musculus |
acyl-CoA synthetase-1 | - |
Mus musculus |
long-chain acyl-CoA synthetase-1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |