Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Triacsin C | competitive inhibitor of palmitate binding for microsomal and mitochondrial enzyme, uncompetitive inhibitor versus CoA. Biphasic Dixon plot, a high-affinity site with a Ki of 0.0001 mM accounts for a maximum of 70% of the inhibition. A low affinity site with a Ki of 0.006 mM accounts for a maximum of 30% inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | high affinity triacsin C inhibition of both mitochondrial and microsomal enzyme form requires high concentrations of free Mg2+. Low affinity triacsin C inhibition is also enhanced by low Mg2+ | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + palmitate + CoA | - |
Homo sapiens | AMP + diphosphate + palmitoyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LACS | - |
Homo sapiens |
long-chain fatty acid:CoA ligase | - |
Homo sapiens |
long-chain fatty acyl-CoA synthetase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | biphasic Dixon plot with the inhibitor triacsin C. A high-affinity site with a Ki of 0.0001 mM accounts for a maximum of 70% of the inhibition. A low affinity site with a Ki of 0.006 mM accounts for a maximum of 30% inhibition | Homo sapiens |