Reference on EC 3.4.21.37 - leukocyte elastase and Organism(s) Homo sapiens and UniProt Accession P08246
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Braun, N.J.; Bodmer, J.L.; Virca, G.D.; Metz-Virca, G.; Maschler, R.; Bieth, J.G.; Schnebli, H.P.
Kinetic studies on the interaction of eglin c with human leukocyte elastase and cathepsin G
Biol. Chem. Hoppe-Seyler
368
299-308
1987
Homo sapiens
Powers, J.C.; Gupton, B.F.; Harley, A.D.; Nishino, N.; Whitley, R.J.
Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones
Biochim. Biophys. Acta
485
156-166
1977
Homo sapiens
Heck, L.W.; Darby, W.L.; Hunter, F.A.; Bhown, A.; Miller, E.J.; Bennett, J.C.
Isolation, characterization, and amino-terminal amino acid sequence analysis of human neutrophil elastase from normal donors
Anal. Biochem.
149
153-162
1985
Homo sapiens
Starkey, P.M.; Barrett, A.J.
Human lysosomal elastase. Catalytic and immunological properties
Biochem. J.
155
265-271
1976
Homo sapiens
Feinstein, G.; Janoff, A.
A rapid method of purification of human granulocyte cationic neutral proteases: purification and further characterization of human granulocyte elastase
Biochim. Biophys. Acta
403
493-505
1975
Homo sapiens
Ohlsson, K.; Olsson, I.
The neutral proteases of human granulocytes. Isolation and partial characterization of granulocyte elastases
Eur. J. Biochem.
42
519-527
1974
Homo sapiens
Nakajima, K.; Powers, J.C.; Ashe, B.M.; Zimmerman, M.
Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site
J. Biol. Chem.
254
4027-4032
1979
Homo sapiens
Blow, A.M.J.
Action of human lysosomal elastase on the oxidized B chain of insulin
Biochem. J.
161
13-16
1977
Homo sapiens
Pacholok, S.G.; Davies, P.; Dorn, C.; Finke, P.; Hanlon, W.A.; Mumford, R.A.; Humes, J.L.
Formation of polymorphonuclear leukocyte elastase:alpha1 proteinase inhibitor complex and Aalpha(1-21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187. A model to characterize inhibitors of polymorphonuclear leukocyte elastase
Biochem. Pharmacol.
49
1513-1520
1995
Homo sapiens
Barrett, A.J.
Leukocyte elastase
Methods Enzymol.
80
581-588
1981
Canis lupus familiaris, Oryctolagus cuniculus, Equus caballus, Homo sapiens, Sus scrofa
-
Junger, W.G.; Hallstrm, S.; Liu, F.C.; Redl, H.; Schlag, G.
The enzymatic and release characteristics of sheep neutrophil elastase: a comparison with human neutrophil elastase
Biol. Chem. Hoppe-Seyler
373
691-698
1992
Ovis aries, Homo sapiens
Weale, C.A.; Bernstein, P.R.; Bryant, C.; Ceccarelli, C.; Damewood, J.R.; Earlay, R.; Feeney, S.W.; Gomes, B.; Kosmider, B.J.; Steelman, G.B.; Thomas, R.M.; Vacek, E.P.; Williams, J.C.; Wolanin, D.J.; Woolson, S.
Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones
J. Med. Chem.
38
98-108
1995
Homo sapiens
Dubin, A.; Potempa, J.; Travis, J.
Structural and functional characterization of elastases from horse neutrophils
Biochem. J.
300
401-406
1994
Equus caballus, Homo sapiens
Korkmaz, B.; Attucci, S.; Hazouard, E.; Ferrandiere, M.; Jourdan, M.L.; Brillard-Bourdet, M.; Juliano, L.; Gauthier, F.
Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates
J. Biol. Chem.
277
39074-39081
2002
Homo sapiens
Jordan, R.E.; Nelson, R.M.; Kilpatrick, J.; Newgren, J.O.; Esmon, P.C.; Fournel, M.A.
Inactivation of human antithrombin by neutrophil elastase. Kinetics of the heparin-dependent reaction
J. Biol. Chem.
264
10493-10500
1989
Homo sapiens
Baici, A.
Interaction of human leukocyte elastase with soluble and insoluble protein substrates. A practical kinetic approach
Biochim. Biophys. Acta
1040
355-364
1990
Homo sapiens
Becker, M.; Franz, G.; Alban, S.
Inhibition of PMN-elastase activity by semisynthetic glucan sulfates
Thromb. Haemost.
89
915-925
2003
Homo sapiens
Kafienah, W.; Buttle, D.J.; Burnett, D.; Hollander, A.P.
Cleavage of native type I collagen by human neutrophil elastase
Biochem. J.
330
897-902
1998
Homo sapiens
Macdonald, S.J.; Dowle, M.D.; Harrison, L.A.; Clarke, G.D.; Inglis, G.G.; Johnson, M.R.; Shah, P.; Smith, R.A.; Amour, A.; Fleetwood, G.; Humphreys, D.C.; Molloy, C.R.; Dixon, M.; Godward, R.E.; Wonacott, A.J.; Singh, O.M.; Hodgson, S.T.; Hardy, G.W.
Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)
J. Med. Chem.
45
3878-3890
2002
Homo sapiens
Kapui, Z.; Varga, M.; Urban-Szabo, K.; Mikus, E.; Szabo, T.; Szeredi, J.; Batori, S.; Finance, O.; Aranyi, P.
Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4 -(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor
J. Pharmacol. Exp. Ther.
305
451-459
2003
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus
Kawamura, T.; Okada, N.; Okada, H.
Elastase from activated human neutrophils activates procarboxypeptidase R
Microbiol. Immunol.
46
225-230
2002
Homo sapiens
Edwards, P.D.; Bernstein, P.R.
Synthetic inhibitors of elastase
Med. Res. Rev.
14
127-194
1994
Homo sapiens
Veale, C.A.; Bernstein, P.R.; Bohnert, C.M.; Brown, F.J.; Bryant, C.; Damewood, J.R., Jr.; Earley, R.; Feeney, S.W.; Edwards, P.D.; Gomes, B.; Hulsizer, J.M.; Kosmider, B.J.; Krell, R.D.; Moore, G.; Salcedo, T.W.; Shaw, A.; Silberstein, D.S.; Steelman, G.B.; Stein, M.; Strimpler, A.; Thomas, R.M.; Vacek, E.P.; Williams, J.C.; Wolanin, D.J.; Woolson, S.
Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase
J. Med. Chem.
40
3173-3181
1997
Homo sapiens
Wei, A.Z.; Mayr, I.; Bode, W.
The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor
FEBS Lett.
234
367-373
1988
Homo sapiens (P08246), Homo sapiens
Szardenings, M.; Vasel, B.; Hecht, H.J.; Collins, J.; Schomburg, D.
Highly effective protease inhibitors from variants of human pancreatic secretory trypsin inhibitor (hPSTI): an assessment of 3-D structure-based protein design
Protein Eng.
8
45-52
1995
Homo sapiens
Jackson, D.S.; Brown, A.D.; Schaeper, R.J.; Powers, J.C.
A kinetic study of the hydrolysis of the N-tosylalanine ester of 3-hydroxy-5-phenylpyrrole and related compounds by human leukocyte elastase
Arch. Biochem. Biophys.
323
108-114
1995
Homo sapiens
Balduyck, M.; Piva, F.; Mizon, C.; Maes, P.; Malki, N.; Gressier, B.; Michalski, C.; Mizon, J.
Human leucocyte elastase (HLE) preferentially cleaves the heavy chain H2 of inter-alpha-trypsin inhibitor (ITI)
Biol. Chem. Hoppe-Seyler
374
895-901
1993
Homo sapiens
Eckle, I.; Seitz, R.; Egbring, R.; Kolb, G.; Havemann, K.
Protein C degradation in vitro by neutrophil elastase
Biol. Chem. Hoppe-Seyler
372
1007-1013
1991
Homo sapiens
Sinha, S.; Watorek, W.; Karr, S.; Giles, J.; Bode, W.; Travis, J.
Primary structure of human neutrophil elastase
Proc. Natl. Acad. Sci. USA
84
2228-2232
1987
Homo sapiens (P08246), Homo sapiens
Navia, M.A.; McKeever, B.M.; Springer, J.P.; Lin, T.Y.; Williams, H.R.; Fluder, E.M.; Dorn, C.P.; Hoogsteen, K.
Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution
Proc. Natl. Acad. Sci. USA
86
7-11
1989
Homo sapiens (P08246), Homo sapiens
Okada, Y.; Tsuboi, S.; Tsuda, Y.; Nagamatsu, Y.; Yamamoto, J.
Synthesis of a trihexacontapeptide corresponding to the sequence 8-70 of eglin c and studies on the relationship between the structure and the inhibitory activity against human leukocyte elastase, cathepsin G and alpha-chymotrypsin
FEBS Lett.
272
113-116
1990
Homo sapiens
Bode, W.; Wei, A.Z.; Huber, R.; Meyer, E.; Travis, J.; Neumann, S.
X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor
EMBO J.
5
2453-2458
1986
Homo sapiens (P08246), Homo sapiens
Baici, A.; Pelloso, R.; Horler, D.
The kinetic mechanism of inhibition of human leukocyte elastase by MR889, a new cyclic thiolic compound
Biochem. Pharmacol.
39
919-924
1990
Homo sapiens
Stein, R.L.; Strimpler, A.M.; Hori, H.; Powers, J.C.
Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements
Biochemistry
26
1301-1305
1987
Homo sapiens
Ying, Q.L.; Simon, S.R.
Kinetics of the inhibition of human leukocyte elastase by elafin, a 6-kilodalton elastase-specific inhibitor from human skin
Biochemistry
32
1866-1874
1993
Homo sapiens
Heinz, D.W.; Liersch, M.; Grutter, M.G.
Crystallization of human leukocyte elastase with its inhibitor Pro44-eglin c
J. Mol. Biol.
207
641-642
1989
Homo sapiens
Ying, Q.L.; Kemme, M.; Simon, S.R.
Alginate, the slime exopolysaccharide of Pseudomonas aeruginosa, binds human leukocyte elastase, retards inhibition by alpha 1-proteinase inhibitor, and accelerates inhibition by secretory leukoprotease inhibitor
Am. J. Respir. Cell Mol. Biol.
15
283-291
1996
Homo sapiens
Korkmaz, B.; Attucci, S.; Moreau, T.; Godat, E.; Juliano, L.; Gauthier, F.
Design and use of highly specific substrates of neutrophil elastase and proteinase 3
Am. J. Respir. Cell Mol. Biol.
30
801-807
2004
Homo sapiens
Nakao, A.; Partis, R.A.; Jung, G.P.; Mueller, R.A.
SC-39026, a specific human neutrophil elastase inhibitor
Biochem. Biophys. Res. Commun.
147
666-674
1987
Cricetulus griseus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa
Redini, F.; Tixier, J.M.; Petitou, M.; Choay, J.; Robert, L.; Hornebeck, W.
Inhibition of leucocyte elastase by heparin and its derivatives
Biochem. J.
252
515-519
1988
Homo sapiens, Rattus norvegicus
Sissi, C.; Lucatello, L.; Naggi, A.; Torri, G.; Palumbo, M.
Interactions of low-molecular-weight semi-synthetic sulfated heparins with human leukocyte elastase and human Cathepsin G
Biochem. Pharmacol.
71
287-293
2006
Homo sapiens
Doring, G.; Goldstein, W.; Botzenhart, K.; Kharazmi, A.; Schiotz, P.O.; Hoiby, N.; Dasgupta, M.
Elastase from polymorphonuclear leucocytes: a regulatory enzyme in immune complex disease
Clin. Exp. Immunol.
64
597-605
1986
Homo sapiens
Zani, M.L.; Nobar, S.M.; Lacour, S.A.; Lemoine, S.; Boudier, C.; Bieth, J.G.; Moreau, T.
Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre-elafin (trappin-2) expressed in Pichia pastoris
Eur. J. Biochem.
271
2370-2378
2004
Homo sapiens
Sommerhoff, C.P.; Krell, R.D.; Williams, J.L.; Gomes, B.C.; Strimpler, A.M.; Nadel, J.A.
Inhibition of human neutrophil elastase by ICI 200,355
Eur. J. Pharmacol.
193
153-158
1991
Homo sapiens
Jones, A.; Elphick, H.; Pettitt, E.; Everard, M.L.; Evans, G.S.
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase
Eur. Respir. J.
19
1136-1141
2002
Homo sapiens
Tralau, T.; Meyer-Hoffert, U.; Schroeder, J.M.; Wiedow, O.
Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis
Exp. Dermatol.
13
316-325
2004
Homo sapiens
Poncz, L.; Jentoft, N.; Ho, M.C.; Dearborn, D.G.
Kinetics of proteolysis of hog gastric mucin by human neutrophil elastase and by Pseudomonas aeruginosa elastase
Infect. Immun.
56
703-704
1988
Homo sapiens
Potempa, J.; Dubin, A.; Watorek, W.; Travis, J.
An elastase inhibitor from equine leukocyte cytosol belongs to the serpin superfamily. Further characterization and amino acid sequence of the reactive center
J. Biol. Chem.
263
7364-7369
1988
Equus caballus, Homo sapiens
Doring, G.; Frank, F.; Boudier, C.; Herbert, S.; Fleischer, B.; Bellon, G.
Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis
J. Immunol.
154
4842-4850
1995
Homo sapiens
Uejima, Y.; Kokubo, M.; Oshida, J.; Kawabata, H.; Kato, Y.; Fujii, K.
5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase
J. Pharmacol. Exp. Ther.
265
516-523
1993
Cricetulus griseus, Homo sapiens
Rees, D.D.; Brain, J.D.; Wohl, M.E.; Humes, J.L.; Mumford, R.A.
Inhibition of neutrophil elastase in CF sputum by L-658,758
J. Pharmacol. Exp. Ther.
283
1201-1206
1997
Homo sapiens
Wei, L.; Lai, Z.; Gan, X.; Alliston, K.R.; Zhong, J.; Epp, J.B.; Tu, J.; Perera, A.B.; Van Stipdonk, M.; Groutas, W.C.
Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process
Arch. Biochem. Biophys.
429
60-70
2004
Homo sapiens
Beyer, G.; Melzig, M.F.
Effects of propolis on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells and on neutrophil elastase activity
Biol. Pharm. Bull.
28
1183-1186
2005
Homo sapiens
Shao, M.X.; Nadel, J.A.
Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme
J. Immunol.
175
4009-4016
2005
Homo sapiens
Meyer-Hoffert, U.; Wingertszahn, J.; Wiedow, O.
Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation
J. Invest. Dermatol.
123
338-345
2004
Homo sapiens
Maffia, P.C.; Zittermann, S.E.; Scimone, M.L.; Tateosian, N.; Amiano, N.; Guerrieri, D.; Lutzky, V.; Rosso, D.; Romeo, H.E.; Garcia, V.E.; Issekutz, A.C.; Chuluyan, H.E.
Neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability
Am. J. Pathol.
171
928-937
2007
Homo sapiens
Roghanian, A.; Drost, E.M.; MacNee, W.; Howie, S.E.; Sallenave, J.M.
Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase
Am. J. Respir. Crit. Care Med.
174
1189-1198
2006
Homo sapiens
Rescher, U.; Goebeler, V.; Wilbers, A.; Gerke, V.
Proteolytic cleavage of annexin 1 by human leukocyte elastase
Biochim. Biophys. Acta
1763
1320-1324
2006
Homo sapiens
Lombard, C.; Arzel, L.; Bouchu, D.; Wallach, J.; Saulnier, J.
Human leukocyte elastase hydrolysis of peptides derived from human elastin exon 24
Biochimie
88
1915-1921
2006
Homo sapiens
Schietroma, M.; Carlei, F.; Cappelli, S.; Pescosolido, A.; Lygidakis, N.J.; Amicucci, G.
Effects of cholecystectomy (laparoscopic versus open) on PMN-elastase
Hepatogastroenterology
54
342-345
2007
Homo sapiens
Thusberg, J.; Vihinen, M.
Bioinformatic analysis of protein structure-function relationships: case study of leukocyte elastase (ELA2) missense mutations
Hum. Mutat.
27
1230-1243
2006
Homo sapiens (P08246), Homo sapiens
Sonawane, A.; Jyot, J.; During, R.; Ramphal, R.
Neutrophil elastase an innate immunity effector molecule represses flagellin transcription in Pseudomonas aeruginosa
Infect. Immun.
74
6682 - 6689
2006
Homo sapiens
Campbell, E.J.; Owen, C.A.
The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G
J. Biol. Chem.
282
14645-14654
2007
Homo sapiens
Dell'Aica, I.; Sartor, L.; Galletti, P.; Giacomini, D.; Quintavalla, A.; Calabrese, F.; Giacometti, C.; Brunetta, E.; Piazza, F.; Agostini, C.; Garbisa, S.
Inhibition of leukocyte elastase, polymorphonuclear chemoinvasion, and inflammation-triggered pulmonary fibrosis by a 4-alkyliden-beta-lactam with a galloyl moiety
J. Pharmacol. Exp. Ther.
316
539-546
2006
Homo sapiens
Santagati, N.A.; Salerno, L.; Di Giacomo, C.; Vanella, L.; Ronsisvalle, S.
Inhibition of human leukocyte elastase by novel thieno-1,3-oxazin-4-ones and thieno-1,3-thioxazin-4-ones
Lett. Drug Des. Discov.
4
386-393
2007
Homo sapiens
-
Woods, D.E.; Cantin, A.; Cooley, J.; Kenney, D.M.; Remold-O'Donnell, E.
Aerosol treatment with MNEI suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection
Pediatr. Pulmonol.
39
141-149
2005
Homo sapiens, Rattus norvegicus
Attucci, S.; Gauthier, A.; Korkmaz, B.; Delepine, P.; Martino, M.F.; Saudubray, F.; Diot, P.; Gauthier, F.
EPI-hNE4, a proteolysis-resistant inhibitor of human neutrophil elastase and potential anti-inflammatory drug for treating cystic fibrosis
J. Pharmacol. Exp. Ther.
318
803-809
2006
Homo sapiens
Chan, S.C.; Leung, V.O.; Ip, M.S.; Shum, D.K.
Shed syndecan-1 restricts neutrophil elastase from alpha1-antitrypsin in neutrophilic airway inflammation
Am. J. Respir. Cell Mol. Biol.
41
620-628
2009
Homo sapiens
Padron-Barthe, L.; Courta, J.; Lepretre, C.; Nagbou, A.; Torriglia, A.
Leukocyte Elastase Inhibitor, the precursor of L-DNase II, inhibits apoptosis by interfering with caspase-8 activation
Biochim. Biophys. Acta
1783
1755-1766
2008
Homo sapiens
Kaellquist, L.; Hansson, M.; Persson, A.M.; Janssen, H.; Calafat, J.; Tapper, H.; Olsson, I.
The tetraspanin CD63 is involved in granule targeting of neutrophil elastase
Blood
112
3444-3454
2008
Homo sapiens
Alla, V.; Kashyap, A.; Gregor, S.; Theobald, M.; Heid, H.; Galle, P.R.; Strand, D.; Strand, S.
Human leukocyte elastase counteracts matrix metalloproteinase-7 induced apoptosis resistance of tumor cells
Cancer Lett.
268
331-339
2008
Homo sapiens
Mehner, C.; Mueller, D.; Kehraus, S.; Hautmann, S.; Guetschow, M.; Koenig, G.M.
New peptolides from the cyanobacterium Nostoc insulare as selective and potent inhibitors of human leukocyte elastase
ChemBioChem
9
2692-2703
2008
Homo sapiens
de Lange, T.E.; Simsek, S.; Kramer, M.H.; Nanayakkara, P.W.
A case of cocaine-induced panhypopituitarism with human neutrophil elastase-specific anti-neutrophil cytoplasmic antibodies
Eur. J. Endocrinol.
160
499-502
2009
Homo sapiens
Kelly, E.; Greene, C.M.; McElvaney, N.G.
Targeting neutrophil elastase in cystic fibrosis
Expert Opin. Ther. Targets
12
145-157
2008
Homo sapiens
Henriksen, P.A.; Sallenave, J.M.
Human neutrophil elastase: mediator and therapeutic target in atherosclerosis
Int. J. Biochem. Cell Biol.
40
1095-1100
2008
Homo sapiens
Lepretre, C.; Scovassi, A.I.; Shah, G.M.; Torriglia, A.
Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis
Int. J. Biochem. Cell Biol.
41
1046-1054
2009
Homo sapiens
Roghanian, A.; Sallenave, J.M.
Neutrophil elastase (NE) and NE inhibitors: canonical and noncanonical functions in lung chronic inflammatory diseases (cystic fibrosis and chronic obstructive pulmonary disease)
J. Aerosol Med. Pulm. Drug Deliv.
21
125-144
2008
Homo sapiens
Nishiyama, T.
Changes in polymorphonuclear leukocyte elastase concentrations and hemolysis parameters in patients transfused with different blood preparations, and in the blood preparations themselves
J. Anesth.
22
117-124
2008
Homo sapiens
Toyama, S.; Hatori, F.; Shimizu, A.; Takagi, T.
A neutrophil elastase inhibitor, sivelestat, improved respiratory and cardiac function in pediatric cardiovascular surgery with cardiopulmonary bypass
J. Anesth.
22
341-346
2008
Homo sapiens
Guyot, N.; Butler, M.W.; McNally, P.; Weldon, S.; Greene, C.M.; Levine, R.L.; ONeill, S.J.; Taggart, C.C.; McElvaney, N.G.
Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis
J. Biol. Chem.
283
32377-32385
2008
Homo sapiens
Huang, W.; Yamamoto, Y.; Li, Y.; Dou, D.; Alliston, K.R.; Hanzlik, R.P.; Williams, T.D.; Groutas, W.C.
X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives
J. Med. Chem.
51
2003-2008
2008
Homo sapiens
Averhoff, P.; Kolbe, M.; Zychlinsky, A.; Weinrauch, Y.
Single residue determines the specificity of neutrophil elastase for Shigella virulence factors
J. Mol. Biol.
377
1053-1066
2008
Homo sapiens
Ujiie, Y.; Shimada, A.; Komatsu, K.; Gomi, K.; Oida, S.; Arai, T.; Fukae, M.
Degradation of noncollagenous components by neutrophil elastase reduces the mechanical strength of rat periodontal ligament
J. Periodont. Res.
43
22-31
2008
Homo sapiens
Koizumi, M.; Fujino, A.; Fukushima, K.; Kamimura, T.; Takimoto-Kamimura, M.
Complex of human neutrophil elastase with 1/2SLPI
J. Synchrotron Radiat.
15
308-311
2008
Homo sapiens
Goulet, B.; Markovic, Y.; Leduy, L.; Nepveu, A.
Proteolytic processing of cut homeobox 1 by neutrophil elastase in the MV4;11 myeloid leukemia cell line
Mol. Cancer Res.
6
644-653
2008
Homo sapiens
Matsuoka, T.; Jin, E.; Tachihara, A.; Ghazizadeh, M.; Nakajima, A.; Yoshino, S.; Katayama, Y.; Kawanami, O.
Induction of pulmonary thromboembolism by neutrophil elastase in collagen-induced arthritis mice and effect of recombinant human soluble thrombomodulin
Pathobiology
75
295-305
2008
Homo sapiens
Ekenaes, C.; Zebrowska, A.; Schuler, B.; Vrede, T.; Andreasen, K.; Backlund, A.; Merfort, I.; Bohlin, L.
Screening for anti-inflammatory activity of 12 Arnica (Asteraceae) species assessed by inhibition of NF-kappaB and release of human neutrophil elastase
Planta Med.
74
1789-1794
2008
Homo sapiens
Wang, Z.; Chen, F.; Zhai, R.; Zhang, L.; Su, L.; Lin, X.; Thompson, T.; Christiani, D.C.
Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development
PLoS ONE
4
e4380
2009
Homo sapiens
Sullivan, A.L.; Dafforn, T.; Hiemstra, P.S.; Stockley, R.A.
Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex
Respir. Res.
9
60
2008
Homo sapiens
Hashimoto, S.; Okayama, Y.; Shime, N.; Kimura, A.; Funakoshi, Y.; Kawabata, K.; Ishizaka, A.; Amaya, F.
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome
Respirology
13
581-584
2008
Homo sapiens
Arakawa, N.S.; Schorr, K.; Ambrosio, S.R.; Merfort, I.; Da Costa, F.B.
Further sesquiterpene lactones from Viguiera robusta and the potential anti-inflammatory activity of a heliangolide: inhibition of human neutrophil elastase release
Z. Naturforsch. C
63
533-538
2008
Homo sapiens
Suzuki, T.; Yamashita, C.; Zemans, R.L.; Briones, N.; Van Linden, A.; Downey, G.P.
Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway
Am. J. Respir. Cell Mol. Biol.
41
742-755
2009
Homo sapiens
Lepretre, C.; Sidoli, G.; Scovassi, A.I.; Torriglia, A.
Leukocyte elastase inhibitor: a new regulator of PARP-1
Ann. N. Y. Acad. Sci.
1171
25-31
2009
Homo sapiens
Aimetti, A.A.; Tibbitt, M.W.; Anseth, K.S.
Human neutrophil elastase responsive delivery from poly(ethylene glycol) hydrogels
Biomacromolecules
10
1484-1489
2009
Homo sapiens
Shreder, K.R.; Cajica, J.; Du, L.; Fraser, A.; Hu, Y.; Kohno, Y.; Lin, E.C.; Liu, S.J.; Okerberg, E.; Pham, L.; Wu, J.; Kozarich, J.W.
Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase
Bioorg. Med. Chem. Lett.
19
4743-4746
2009
Homo sapiens
Xu, G.H.; Kim, Y.H.; Chi, S.W.; Choo, S.J.; Ryoo, I.J.; Ahn, J.S.; Yoo, I.D.
Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa
Bioorg. Med. Chem. Lett.
20
513-515
2010
Homo sapiens
Inoue, Y.; Omodani, T.; Shiratake, R.; Okazaki, H.; Kuromiya, A.; Kubo, T.; Sato, F.
Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury
Bioorg. Med. Chem.
17
7477-7486
2009
Homo sapiens
Skokowa, J.; Fobiwe, J.P.; Dan, L.; Thakur, B.K.; Welte, K.
Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1
Blood
114
3044-3051
2009
Homo sapiens
Gruber, R.; Nadir, J.; Haas, R.
Neutrophil elastase activity and concentrations of interleukin1-beta in crevicular fluid after immediate replacement and immediate loading of implants
Br. J. Oral Maxillofac. Surg.
48
228-231
2010
Homo sapiens
Ewen, D.; Clarke, S.L.; Smith, J.R.; Berger, C.; Salmon, G.; Trevethick, M.; Shute, J.K.
The role of protease-activated receptors PAR-1 and PAR-2 in the repair of 16HBE 14o(-) epithelial cell monolayers in vitro
Clin. Exp. Allergy
40
435-449
2010
Homo sapiens
Fischer, B.M.; Domowicz, D.A.; Zheng, S.; Carter, J.L.; McElvaney, N.G.; Taggart, C.; Lehmann, J.R.; Voynow, J.A.; Ghio, A.J.
Neutrophil elastase increases airway epithelial nonheme iron levels
Clin. Transl. Sci.
2
333-339
2009
Homo sapiens
Kawahara, Y.; Ninomiya, I.; Fujimura, T.; Funaki, H.; Nakagawara, H.; Takamura, H.; Oyama, K.; Tajima, H.; Fushida, S.; Inaba, H.; Kayahara, M.
Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer
Dis. Esophagus
23
329-339
2010
Homo sapiens
Kobayashi, M.; Irinoda, T.; Akiyama, Y.; Meguro, E.; Hayakawa, Y.; Funato, O.; Takagane, A.
Effect of a selective neutrophil elastase inhibitor on early recovery from body water imbalance after transthoracic esophagectomy
Dis. Esophagus
23
565-571
2010
Homo sapiens
Hsieh, P.W.; Yu, H.P.; Chang, Y.J.; Hwang, T.L.
Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats
Eur. J. Med. Chem.
45
3111-3115
2010
Homo sapiens
Hajjar, E.; Broemstrup, T.; Kantari, C.; Witko-Sarsat, V.; Reuter, N.
Structures of human proteinase 3 and neutrophil elastase - so similar yet so different
FEBS J.
277
2238-2254
2010
Homo sapiens (P08246), Homo sapiens
Ikegame, Y.; Yamashita, K.; Hayashi, S.I.; Yoshimura, S.I.; Nakashima, S.; Iwama, T.
Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema
Hypertens. Res.
33
703-707
2010
Homo sapiens
Duvoix, A.; Mackay, R.M.; Henderson, N.; McGreal, E.; Postle, A.; Reid, K.; Clark, H.
Physiological concentration of calcium inhibits elastase-induced cleavage of a functional recombinant fragment of surfactant protein D
Immunobiology
216
72-79
2010
Homo sapiens, Pseudomonas aeruginosa
Fujii, M.; Miyagi, Y.; Bessho, R.; Nitta, T.; Ochi, M.; Shimizu, K.
Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass
Interact. Cardiovasc. Thorac. Surg.
10
859-862
2010
Homo sapiens
Abe, T.; Usui, A.; Oshima, H.; Akita, T.; Ueda, Y.
A pilot randomized study of the neutrophil elastase inhibitor, Sivelestat, in patients undergoing cardiac surgery
Interact. Cardiovasc. Thorac. Surg.
9
236-240
2009
Homo sapiens
Ho, S.C.; Lee, K.Y.; Chan, Y.F.; Kuo, L.W.; Ito, K.; Adcock, I.M.; Chen, B.C.; Sheu, J.R.; Lin, C.H.; Kuo, H.P.
Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor
J. Immunol.
183
411-420
2009
Homo sapiens
Weldon, S.; McNally, P.; McElvaney, N.G.; Elborn, J.S.; McAuley, D.F.; Wartelle, J.; Belaaouaj, A.; Levine, R.L.; Taggart, C.C.
Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation
J. Immunol.
183
8148-8156
2009
Homo sapiens
Piper, M.G.; Massullo, P.R.; Loveland, M.; Druhan, L.J.; Kindwall-Keller, T.L.; Ai, J.; Copelan, A.; Avalos, B.R.
Neutrophil elastase downmodulates native G-CSFR expression and granulocyte-macrophage colony formation
J. Inflamm.
7
5
2010
Homo sapiens
Thongyoo, P.; Bonomelli, C.; Leatherbarrow, R.J.; Tate, E.W.
Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold
J. Med. Chem.
52
6197-6200
2009
Homo sapiens
Mulchande, J.; Oliveira, R.; Carrasco, M.; Gouveia, L.; Guedes, R.C.; Iley, J.; Moreira, R.
4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase
J. Med. Chem.
53
241-253
2010
Homo sapiens
Kim, Y.H.; Ryoo, I.J.; Choo, S.J.; Xu, G.H.; Lee, S.; Seok, S.J.; Bae, K.; Yoo, I.D.
Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca
J. Microbiol. Biotechnol.
19
1139-1141
2009
Homo sapiens
Hayashi, M.; Oya, A.; Miyake, H.; Nakai, A.; Takeshita, T.
Effect of urinary trypsin inhibitor on preterm labor with high granulocyte elastase concentration in cervical secretions
J. Nippon Med. Sch.
77
80-85
2010
Homo sapiens
Braun, B.C.; Meyer, H.A.; Reetz, A.; Fuhrmann, U.; Koehrle, J.
Effect of mutations of the human serpin protein corticosteroid-binding globulin on cortisol-binding, thermal and protease sensitivity
J. Steroid Biochem. Mol. Biol.
120
30-37
2010
Homo sapiens
Salipante, S.J.; Rojas, M.E.; Korkmaz, B.; Duan, Z.; Wechsler, J.; Benson, K.F.; Person, R.E.; Grimes, H.L.; Horwitz, M.S.
Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase
Mol. Cell. Biol.
29
4394-4405
2009
Homo sapiens
Jackson, P.L.; Xu, X.; Wilson, L.; Weathington, N.M.; Clancy, J.P.; Blalock, J.E.; Gaggar, A.
Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction
Mol. Med.
16
159-166
2010
Homo sapiens
Zynek-Litwin, M.; Kuzniar, J.; Marchewka, Z.; Kopec, W.; Kusztal,M.; Patrzalek, D.; Biecek, P.; Klinger, M.
Plasma and urine leukocyte elastase-alpha1 protease inhibitor complex as a marker of early and long-term kidney graft function
Nephrol. Dial. Transplant.
25
2346-2351
2010
Homo sapiens
Topic, A.; Ljujic, M.; Nikolic, A.; Petrovic-Stanojevic, N.; Dopudja-Pantic, V.; Mitic-Milikic, M.; Radojkovic, D.
Alpha-1-antitrypsin phenotypes and neutrophil elastase gene promoter polymorphisms in lung cancer
Pathol. Oncol. Res.
17
75-80
2011
Homo sapiens
Sienczyk, M.; Winiarski, L.; Kasperkiewicz, P.; Psurski, M.; Wietrzyk, J.; Oleksyszyn, J.
Simple phosphonic inhibitors of human neutrophil elastase
Bioorg. Med. Chem. Lett.
21
1310-1314
2011
Homo sapiens
Dou, D.; He, G.; Kuang, R.; Fu, Q.; Venkataraman, R.; Groutas, W.C.
Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase
Bioorg. Med. Chem.
18
6646-6650
2010
Homo sapiens
Crocetti, L.; Giovannoni, M.P.; Schepetkin, I.A.; Quinn, M.T.; Khlebnikov, A.I.; Cilibrizzi, A.; Piaz, V.D.; Graziano, A.; Vergelli, C.
Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase
Bioorg. Med. Chem.
19
4460-4472
2011
Homo sapiens
Ramachandran, R.; Mihara, K.; Chung, H.; Renaux, B.; Lau, C.S.; Muruve, D.A.; DeFea, K.A.; Bouvier, M.; Hollenberg, M.D.
Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)
J. Biol. Chem.
286
24638-24648
2011
Homo sapiens
Papayannopoulos, V.; Metzler, K.D.; Hakkim, A.; Zychlinsky, A.
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
J. Cell Biol.
191
677-691
2010
Homo sapiens
Estacio, S.G.; Moreira, R.; Guedes, R.C.
Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations
J. Chem. Inf. Model.
51
1690-1702
2011
Homo sapiens
Hansen, G.; Gielen-Haertwig, H.; Reinemer, P.; Schomburg, D.; Harrenga, A.; Niefind, K.
Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor
J. Mol. Biol.
409
681-691
2011
Homo sapiens (P08246), Homo sapiens
Nogami, K.; Ogiwara, K.; Matsumoto, T.; Nishiya, K.; Takeyama, M.; Shima, M.
Mechanisms of human neutrophil elastase-catalysed inactivation of factor VIII(a)
Thromb. Haemost.
105
968-980
2011
Homo sapiens
Madoiwa, S.; Tanaka, H.; Nagahama, Y.; Dokai, M.; Kashiwakura, Y.; Ishiwata, A.; Sakata, A.; Yasumoto, A.; Ohmori, T.; Mimuro, J.; Sakata, Y.
Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation
Thromb. Res.
127
349-355
2011
Homo sapiens
Dokai, M.; Madoiwa, S.; Yasumoto, A.; Kashiwakura, Y.; Ishiwata, A.; Sakata, A.; Makino, N.; Ohmori, T.; Mimuro, J.; Sakata, Y.
Local regulation of neutrophil elastase activity by endogenous alpha1-antitrypsin in lipopolysaccharide-primed hematological cells
Thromb. Res.
128
283-292
2011
Homo sapiens
Collins, J.; Szardenings, M.; Maywald, F.; Blcker, H.; Frank, R.; Hecht, H.J.; Vasel, B.; Schomburg, D.; Fink, E.; Fritz, H.
Human leukocyte elastase inhibitors: designed variants of human pancreatic secretory trypsin inhibitor (hPSTI)
Biol. Chem. Hoppe-Seyler
371
29-36
1990
Homo sapiens
Ungurs, M.J.; Sinden, N.J.; Stockley, R.A.
Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD
Am. J. Physiol. Lung Cell Mol. Physiol.
306
L80-L87
2014
Homo sapiens
Popow-Stellmaszyk, J.; Wysocka, M.; Lesner, A.; Korkmaz, B.; Rolka, K.
A new proteinase 3 substrate with improved selectivity over human neutrophil elastase
Anal. Biochem.
442
75-82
2013
Homo sapiens
Lee, H.H.; Sung, M.H.
The neutrophil elastase mutant affects viability and differentiation of the human monocytic THP-1 cell
Cell Biochem. Funct.
31
305-311
2013
Homo sapiens
Schmelzer, C.E.; Jung, M.C.; Wohlrab, J.; Neubert, R.H.; Heinz, A.
Does human leukocyte elastase degrade intact skin elastin?
FEBS J.
279
4191-4200
2012
Homo sapiens
Lee, I.; Bae, K.; Kuk Yoo, J.; Ryoo, I.; Kim, B.; Seog Ahn, J.; Yoo, I.
Inhibition of human neutrophil elastase by ergosterol derivatives from the mycelium of Phellinus linteus
J. Antibiot.
65
437-440
2012
Homo sapiens
Gregory, A.D.; Kliment, C.R.; Metz, H.E.; Kim, K.H.; Kargl, J.; Agostini, B.A.; Crum, L.T.; Oczypok, E.A.; Oury, T.A.; Houghton, A.M.
Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis
J. Leukoc. Biol.
98
143-152
2015
Homo sapiens
Pivetta, E.; Danussi, C.; Wassermann, B.; Modica, T.M.; Del Bel Belluz, L.; Canzonieri, V.; Colombatti, A.; Spessotto, P.
Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1
Matrix Biol.
34
22-32
2014
Homo sapiens
Huang, G.; Feng, L.; Liu, B.; He, Y.; Li, Y.; Chen, Y.
Synthesis and biological evaluation of nigranoic acid esters as novel human neutrophil elastase inhibitors
Nat. Prod. Res.
29
1650-1656
2015
Homo sapiens
Avlonitis, N.; Debunne, M.; Aslam, T.; McDonald, N.; Haslett, C.; Dhaliwal, K.; Bradley, M.
Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase
Org. Biomol. Chem.
11
4414-4418
2013
Homo sapiens
Feng, L.; Liu, X.; Zhu, W.; Guo, F.; Wu, Y.; Wang, R.; Chen, K.; Huang, C.; Li, Y.
Inhibition of human neutrophil elastase by pentacyclic triterpenes
PLoS ONE
8
e82794
2013
Homo sapiens
Novovic, S.; Andersen, A.M.; Nord, M.; Astrand, M.; Ottosson, T.; Jorgensen, L.N.; Hansen, M.B.
Activity of neutrophil elastase reflects the progression of acute pancreatitis
Scand. J. Clin. Lab. Invest.
73
485-493
2013
Homo sapiens
Hochscherf, J.; Pietsch, M.; Tieu, W.; Kuan, K.; Abell, A.D.; Guetschow, M.; Niefind, K.
Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2 site binding inhibitor
Acta Crystallogr. Sect. F
74
480-489
2018
Homo sapiens (P08246), Homo sapiens
Liu, S.Y.; Xiong, H.; Li, R.R.; Yang, W.C.; Yang, G.F.
Activity-based near-infrared fluorogenic probe for enabling in vitro and in vivo profiling of neutrophil elastase
Anal. Chem.
91
3877-3884
2019
Homo sapiens
Fu, Z.; Thorpe, M.; Akula, S.; Chahal, G.; Hellman, L.T.
Extended cleavage specificity of human neutrophil elastase, human proteinase 3, and their distant ortholog clawed frog PR3 - three elastases with similar primary but different extended specificities and stability
Front. Immunol.
9
2387
2018
Homo sapiens
Tan, X.F.; Kim, D.W.; Song, Y.H.; Kim, J.Y.; Yuk, H.J.; Wang, Y.; Curtis-Long, M.J.; Park, K.H.
Human neutrophil elastase inhibitory potential of flavonoids from Campylotropis hirtella and their kinetics
J. Enzyme Inhib. Med. Chem.
31
16-22
2016
Homo sapiens
Yang, R.; Zhong, L.; Yang, X.Q.; Jiang, K.L.; Li, L.; Song, H.; Liu, B.Z.
Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling
Mol. Med. Rep.
13
4175-4182
2016
Homo sapiens
Wiesmeier, M.; Gautam, S.; Kirschnek, S.; Haecker, G.
Characterisation of neutropenia-associated neutrophil elastase mutations in a murine differentiation model in vitro and in vivo
PLoS ONE
11
e0168055
2016
Homo sapiens, Mus musculus
