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Literature summary for 3.4.21.37 extracted from

  • Nakao, A.; Partis, R.A.; Jung, G.P.; Mueller, R.A.
    SC-39026, a specific human neutrophil elastase inhibitor (1987), Biochem. Biophys. Res. Commun., 147, 666-674.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid SC-39026 Cricetulus griseus
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid SC-39026, reversible non-competitive inhibition at low concentrations (0.0005-0.00125 mM), mixed type inhibition at higher concentrations Homo sapiens
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid SC-39026 Oryctolagus cuniculus
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid SC-39026 Rattus norvegicus
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid SC-39026 Sus scrofa
alpha-1-antitrypsin
-
Oryctolagus cuniculus
methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone
-
Homo sapiens
methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone
-
Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Cricetulus griseus involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome ? protein cleaved at at least one location ?
Elastin + H2O Homo sapiens involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome ? protein cleaved at at least one location ?
Elastin + H2O Rattus norvegicus involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome ? protein cleaved at at least one location ?
Elastin + H2O Sus scrofa involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome ? protein cleaved at at least one location ?
Elastin + H2O Oryctolagus cuniculus involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome ? protein cleaved at at least one location ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
Cricetulus griseus
-
leukocyte
-
Homo sapiens
-
leukocyte
-
Rattus norvegicus
-
leukocyte
-
Sus scrofa
-
leukocyte
-
Oryctolagus cuniculus
-
neutrophil
-
Cricetulus griseus
-
neutrophil
-
Homo sapiens
-
neutrophil
-
Rattus norvegicus
-
neutrophil
-
Sus scrofa
-
neutrophil
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
Cricetulus griseus ?
-
?
Elastin + H2O
-
Homo sapiens ?
-
?
Elastin + H2O
-
Rattus norvegicus ?
-
?
Elastin + H2O
-
Sus scrofa ?
-
?
Elastin + H2O
-
Oryctolagus cuniculus ?
-
?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome Cricetulus griseus ? protein cleaved at at least one location ?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome Homo sapiens ? protein cleaved at at least one location ?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome Rattus norvegicus ? protein cleaved at at least one location ?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome Sus scrofa ? protein cleaved at at least one location ?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome Oryctolagus cuniculus ? protein cleaved at at least one location ?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Cricetulus griseus methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Rattus norvegicus methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Sus scrofa methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Oryctolagus cuniculus methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0015
-
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid pH 8.0, 30°C Homo sapiens