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Literature summary for 3.4.21.37 extracted from

  • Ramachandran, R.; Mihara, K.; Chung, H.; Renaux, B.; Lau, C.S.; Muruve, D.A.; DeFea, K.A.; Bouvier, M.; Hollenberg, M.D.
    Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2) (2011), J. Biol. Chem., 286, 24638-24648.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.37

Inhibitors

Inhibitors Comment Organism Structure
elafin complete inhibition at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proteinase-activated receptor 2 N-terminus + H2O Homo sapiens
-
 GPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSAS + VLTGKLTTVFLP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 7-amino-4-methylcoumarin
-
 ?
proteinase-activated receptor 2 N-terminus + H2O
-
 Homo sapiens GPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSAS + VLTGKLTTVFLP
-
 ?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function neutrophil elastase acts as a biased agonist for proteinase-activated receptor 2. Neutrophil elastase causes a tethered ligand-independent proteinase-activated receptor 2-mediated activation of MAPK that does not involve either receptor internalization or recruitment of beta-arrestin. The enzyme can disarm proteinase-activated receptor 2-dependent calcium responses to trypsin Homo sapiens