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Literature summary for 3.4.21.37 extracted from

  • Mehner, C.; Mueller, D.; Kehraus, S.; Hautmann, S.; Guetschow, M.; Koenig, G.M.
    New peptolides from the cyanobacterium Nostoc insulare as selective and potent inhibitors of human leukocyte elastase (2008), ChemBioChem, 9, 2692-2703.
    View publication on PubMed
Search for more literature for 3.4.21.37

Inhibitors

Inhibitors Comment Organism Structure
insulapeptolide A
-
 Homo sapiens
insulapeptolide B
-
 Homo sapiens
insulapeptolide C
-
 Homo sapiens
insulapeptolide D
-
 Homo sapiens
insulapeptolide E
-
 Homo sapiens
insulapeptolide F
-
 Homo sapiens
insulapeptolide G
-
 Homo sapiens
insulapeptolide H
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
 Homo sapiens ?
-
 ?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
HLE
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000036
-
 insulapeptolide D in 50 mM sodium phosphate buffer (100 mM NaCl, pH 7.8), at 25°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000085
-
 in 50 mM sodium phosphate buffer (100 mM NaCl, pH 7.8), at 25°C Homo sapiens insulapeptolide D
0.00009
-
 in 50 mM sodium phosphate buffer (100 mM NaCl, pH 7.8), at 25°C Homo sapiens insulapeptolide C
0.0001
-
 in 50 mM sodium phosphate buffer (100 mM NaCl, pH 7.8), at 25°C Homo sapiens insulapeptolide B
0.00014
-
 in 50 mM sodium phosphate buffer (100 mM NaCl, pH 7.8), at 25°C Homo sapiens insulapeptolide A
0.0016
-
 in 50 mM sodium phosphate buffer (100 mM NaCl, pH 7.8), at 25°C Homo sapiens insulapeptolide F
0.0027
-
 in 50 mM sodium phosphate buffer (100 mM NaCl, pH 7.8), at 25°C Homo sapiens insulapeptolide H
0.0032
-
 in 50 mM sodium phosphate buffer (100 mM NaCl, pH 7.8), at 25°C Homo sapiens insulapeptolide E
0.0035
-
 in 50 mM sodium phosphate buffer (100 mM NaCl, pH 7.8), at 25°C Homo sapiens insulapeptolide G