Application | Comment | Organism |
---|---|---|
medicine | neutrophil elastase is a major target for the development of compounds that inhibit the progression of long-term lung function decline in chronic obstructive pulmonary disease patients | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with dihydropyrimidone inhibitor, sitting drop vapor diffusion method, using 20% (w/v) PEG 3350 and 0.2 M ammonium citrate (pH 5.0) or uncomplexed enzyme, sitting drop vapor diffusion method, using 1.9 M ammonium sulfate, 5% (w/v) PEG 400, 0.1 M 4-morpholine ethanesulfonic acid/NaOH (pH 6.5), and 20% (v/v) glycerol | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyethyl (4R)-4-[4-cyanophenyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]]-1,2,3,4-tetrahydropyrimidine-5-carboxylate | - |
Homo sapiens | |
GW475151 | suicide inhibitor | Homo sapiens | |
MDL101146 | suicide inhibitor | Homo sapiens | |
MeO-Suc-Ala-Ala-Pro-Ala-CH2Cl | suicide inhibitor | Homo sapiens | |
MeO-Suc-Ala-Ala-Pro-Val-CH2Cl | suicide inhibitor | Homo sapiens | |
OMTKY3 | - |
Homo sapiens | |
SLPI | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08246 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
HNE | - |
Homo sapiens |
neutrophil elastase | - |
Homo sapiens |
neutrophil-released elastase | - |
Homo sapiens |