Literature summary for 3.4.21.37 extracted from

Lee, I.; Bae, K.; Kuk Yoo, J.; Ryoo, I.; Kim, B.; Seog Ahn, J.; Yoo, I.
Inhibition of human neutrophil elastase by ergosterol derivatives from the mycelium of Phellinus linteus (2012), J. Antibiot., 65, 437-440.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(22E,24R)-ergosta-7,22-dien-2alpha,3alpha,9alpha-triol	-	Homo sapiens
(3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide	-	Homo sapiens
(3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide 3-O-beta-D-glucoside	-	Homo sapiens
14alpha-hydroxy-ergosta-4,7,9(11),22-tetraen-3,6-dione	-	Homo sapiens
3beta,5alpha,9alpha-trihydroxy-ergosta-7,22-dien-6-one	-	Homo sapiens
3beta,5alpha-dihydroxy-6beta-methoxyergosta-7,22-diene	-	Homo sapiens
3beta,5alpha-dihydroxy-ergosta-7,22-dien-6-one	-	Homo sapiens
3beta-hydroxy-ergosta-7,22-dien-6-one	-	Homo sapiens
5alpha,6alpha,8alpha,9alpha-diepoxy-ergost-22-en-3beta,7alpha-diol	-	Homo sapiens
5alpha,6alpha-epoxy-ergosta-8(14),22-diene-3beta,7alpha-diol	-	Homo sapiens
5alpha,6alpha-epoxy-ergosta-8(9),22-dien-7-one-3beta-ol	-	Homo sapiens
epigallocatechin gallate	-	Homo sapiens
ergosta-4,7,22-trien-3,6-dione	-	Homo sapiens
ergosta-7,22-dien-2beta,3alpha,9alpha-triol	-	Homo sapiens
ergosta-7,22-dien-3beta,5alpha,6beta,9alpha-tetraol	-	Homo sapiens
ergosterol	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Elastin + H2O	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophil	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Elastin + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
HNE	-	Homo sapiens
neutrophil elastase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0146	-	pH 7.5, 37°C	Homo sapiens	3beta,5alpha-dihydroxy-6beta-methoxyergosta-7,22-diene
0.0205	-	pH 7.5, 37°C	Homo sapiens	14alpha-hydroxy-ergosta-4,7,9(11),22-tetraen-3,6-dione
0.0282	-	pH 7.5, 37°C	Homo sapiens	5alpha,6alpha-epoxy-ergosta-8(14),22-diene-3beta,7alpha-diol
0.0352	-	pH 7.5, 37°C	Homo sapiens	5alpha,6alpha,8alpha,9alpha-diepoxy-ergost-22-en-3beta,7alpha-diol
0.0552	-	pH 7.5, 37°C	Homo sapiens	ergosta-4,7,22-trien-3,6-dione
0.0645	-	pH 7.5, 37°C	Homo sapiens	ergosterol
0.0751	-	pH 7.5, 37°C	Homo sapiens	5alpha,6alpha-epoxy-ergosta-8(9),22-dien-7-one-3beta-ol
0.0775	-	pH 7.5, 37°C	Homo sapiens	ergosta-7,22-dien-3beta,5alpha,6beta,9alpha-tetraol
0.1	-	IC50 above 0.1 mM, pH 7.5, 37°C	Homo sapiens	(3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide
0.1	-	IC50 above 0.1 mM, pH 7.5, 37°C	Homo sapiens	(3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide 3-O-beta-D-glucoside
0.1	-	IC50 above 0.1 mM, pH 7.5, 37°C	Homo sapiens	(22E,24R)-ergosta-7,22-dien-2alpha,3alpha,9alpha-triol
0.1	-	IC50 above 0.1 mM, pH 7.5, 37°C	Homo sapiens	3beta-hydroxy-ergosta-7,22-dien-6-one
0.1	-	IC50 above 0.1 mM, pH 7.5, 37°C	Homo sapiens	3beta,5alpha-dihydroxy-ergosta-7,22-dien-6-one
0.1	-	IC50 above 0.1 mM, pH 7.5, 37°C	Homo sapiens	3beta,5alpha,9alpha-trihydroxy-ergosta-7,22-dien-6-one
0.1	-	IC50 above 0.1 mM, pH 7.5, 37°C	Homo sapiens	ergosta-7,22-dien-2beta,3alpha,9alpha-triol

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Release 2023.1 (January 2023)