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Literature summary for 3.4.21.37 extracted from

  • Xu, G.H.; Kim, Y.H.; Chi, S.W.; Choo, S.J.; Ryoo, I.J.; Ahn, J.S.; Yoo, I.D.
    Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa (2010), Bioorg. Med. Chem. Lett., 20, 513-515.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(-)-epigallocatechin-3-gallate
-
Homo sapiens
(E)-6-O-p-coumaroyl scandoside methyl ester an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant Homo sapiens
(E)-6-O-p-feruloyl scandoside methyl ester an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant Homo sapiens
(E)-6-O-p-methoxycinnamoyl scandoside methyl ester an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant. Molecular docking simulation and structural model for the inhibition of human neutrophil elastase, overview Homo sapiens
(Z)-6-O-p-coumaroyl scandoside methyl ester an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant Homo sapiens
(Z)-6-O-p-methoxycinnamoyl scandoside methyl ester an iridoid glycoside isolated from the methanolic extract of Hedyotis diffusa, usage of air-dried whole plant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0128
-
pH 7.5, 37°C Homo sapiens (-)-epigallocatechin-3-gallate
0.018
-
pH 7.5, 37°C Homo sapiens (E)-6-O-p-methoxycinnamoyl scandoside methyl ester
0.1
-
pH 7.5, 37°C, above Homo sapiens (Z)-6-O-p-methoxycinnamoyl scandoside methyl ester
0.1
-
pH 7.5, 37°C, above Homo sapiens (E)-6-O-p-feruloyl scandoside methyl ester
0.1
-
pH 7.5, 37°C, above Homo sapiens (E)-6-O-p-coumaroyl scandoside methyl ester
0.1
-
pH 7.5, 37°C, above Homo sapiens (Z)-6-O-p-coumaroyl scandoside methyl ester