Literature summary for 3.4.21.37 extracted from

Woods, D.E.; Cantin, A.; Cooley, J.; Kenney, D.M.; Remold-O'Donnell, E.
Aerosol treatment with MNEI suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection (2005), Pediatr. Pulmonol., 39, 141-149.

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Inhibitors

Inhibitors	Comment	Organism	Structure
monocyte/neutrophil elastase inhibitor	i.e. MNEI, a 42 kDA serpin protein	Homo sapiens
monocyte/neutrophil elastase inhibitor	i.e. MNEI, a 42 kDA serpin protein, 96.5% inhibition at 25 nM of a purified recombinant enzyme, in vivo inhibition of neutrophil elastase in rat lungs by daily administration leading to reduced inflammation and injury and enhanced clearance of Pseudomonas aeruginosa, overview, no in vitro bactericidal effect on Pseudomonas aeruginosa	Rattus norvegicus
prolastin	i.e. alpha1-antitrypsin, acts similar to monocyte/neutrophil elastase inhibitor, MNEI	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
airway fluid	high enzyme levels in the airway fluid of patients with cystic fibrosis	Homo sapiens	-
lung	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O	-	Homo sapiens	N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline	-	?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O	-	Rattus norvegicus	N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
neutrophil elastase	-	Homo sapiens
neutrophil elastase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
23	-	assay at	Homo sapiens
23	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens
7.4	-	assay at	Rattus norvegicus

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Release 2023.1 (January 2023)