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Literature summary for 3.4.21.37 extracted from

  • Piper, M.G.; Massullo, P.R.; Loveland, M.; Druhan, L.J.; Kindwall-Keller, T.L.; Ai, J.; Copelan, A.; Avalos, B.R.
    Neutrophil elastase downmodulates native G-CSFR expression and granulocyte-macrophage colony formation (2010), J. Inflamm., 7, 5.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
G-CSF receptor + H2O Homo sapiens neutrophil elastase proteolytically cleaves the G-CSF receptor, G-CSFR, a transmembrane protein, in its extracellular region on neutrophils and blocks G-CSFR-mediated granulopoiesis in vitro, and growth of neutrophils and monocytes, CFU-GM, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
neutrophil from peripheral blood Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
G-CSF receptor + H2O neutrophil elastase proteolytically cleaves the G-CSF receptor, G-CSFR, a transmembrane protein, in its extracellular region on neutrophils and blocks G-CSFR-mediated granulopoiesis in vitro, and growth of neutrophils and monocytes, CFU-GM, overview Homo sapiens ?
-
?
G-CSF receptor + H2O neutrophil elastase proteolytically cleaves the G-CSF receptor, G-CSFR, a transmembrane protein, in its extracellular region on neutrophils and blocks G-CSFR-mediated granulopoiesis in vitro, and growth of neutrophils and monocytes, CFU-GM Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
neutrophil elastase
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Homo sapiens