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Literature summary for 3.4.21.37 extracted from

  • Hsieh, P.W.; Yu, H.P.; Chang, Y.J.; Hwang, T.L.
    Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats (2010), Eur. J. Med. Chem., 45, 3111-3115.
    View publication on PubMed
Search for more literature for 3.4.21.37

Inhibitors

Inhibitors Comment Organism Structure
5-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
5-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
5-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
5-chloro-2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
5-chloro-2-(2-methylphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
7-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
7-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
7-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
7-chloro-2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
7-chloro-2-(2-methylphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
8-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
8-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
8-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
8-chloro-2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
8-chloro-2-(2-methylphenyl)-4H-benzo[d][1,3]oxazin-4-one
-
 Homo sapiens
additional information synthesis and evaluation of benzoxazinone derivatives, inhibitory effect on neutrophil elastase, and effects on enzyme release from FMLP-activated human neutrophils, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-
neutrophil formyl-L-methionyl-L-leucyl-L-phenylalanine-activated neutrophils Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00121
-
 pH 7.4, 25°C Homo sapiens 5-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
0.00138
-
 pH 7.4, 25°C Homo sapiens 7-chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one
0.002
-
 pH 7.4, 25°C Homo sapiens 7-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one
0.00268
-
 pH 7.4, 25°C Homo sapiens 7-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one
0.00648
-
 pH 7.4, 25°C Homo sapiens 5-chloro-2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one
0.0234
-
 pH 7.4, 25°C Homo sapiens 5-chloro-2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one